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Top Articles

#TitleJournalYearCitations
1Fear conditioning induces a lasting potentiation of synaptic currents in vitroNature1997723
2Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and InvasionCancer Cell2009719
3The genetic determinants of the CYP3A5 polymorphismPharmacogenetics and Genomics2001608
4Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunityNature Communications2020480
5Activation of the hedgehog pathway in advanced prostate cancerMolecular Cancer2004391
6An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolutionProceedings of the National Academy of Sciences of the United States of America2003362
74-Hydroxylation of estrogens as marker of human mammary tumors.Proceedings of the National Academy of Sciences of the United States of America1996353
8GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3Mucosal Immunology2018322
9Neurobiology of cocaine abuseTrends in Pharmacological Sciences1992307
10Epac and PKA: a tale of two intracellular cAMP receptorsActa Biochimica Et Biophysica Sinica2008289
11Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's diseaseJournal of Lipid Research2004277
12Structure of Mammalian Cytochrome P450 2B4 Complexed with 4-(4-Chlorophenyl)imidazole at 1.9-Å ResolutionJournal of Biological Chemistry2004272
13Free radical generation by redox cycling of estrogensFree Radical Biology and Medicine1990260
14Oncogenic KRAS Activates Hedgehog Signaling Pathway in Pancreatic Cancer Cells*Journal of Biological Chemistry2007256
15Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic PotentialACS Infectious Diseases2020252
16Drug Discovery Targeting Bromodomain-Containing Protein 4Journal of Medicinal Chemistry2017244
17Nitric oxide induces neurotransmitter release from hippocampal slicesEuropean Journal of Pharmacology1992240
18Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine releaseEuropean Journal of Pharmacology1988235
19Transcription Factor STAT3 as a Novel Molecular Target for Cancer PreventionCancers2014234
20Identification and functional characterization of eight CYP3A4 protein variantsPharmacogenetics and Genomics2001225
21Long-term behavioral and neurodegenerative effects of perinatal phencyclidine administration: implications for schizophreniaNeuroscience2001224
22Primary afferent excitatory transmission recorded intracellularly in vitro from rat medial vestibular neuronsSynapse1989206
23Inhibitory transmission in the basolateral amygdalaJournal of Neurophysiology1991205
24cDNA Cloning and Initial Characterization of CYP3A43, a Novel Human Cytochrome P450Molecular Pharmacology2001196
25Small Molecule Inhibitors Targeting Activator Protein 1 (AP-1)Journal of Medicinal Chemistry2014195
26New insights of epithelial-mesenchymal transition in cancer metastasisActa Biochimica Et Biophysica Sinica2008194
27Recent Advances in Lipid-Based Vesicles and Particulate Carriers for Topical and Transdermal ApplicationJournal of Pharmaceutical Sciences2017194
28Genotoxic effects of estrogensMutation Research - Reviews in Genetic Toxicology1990192
294-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America1995185
30Induction of covalent DNA adducts in rodents by tamoxifenCancer Research1992183
31Serotonergic mechanisms involved in the discriminative stimulus, reinforcing and subjective effects of cocainePsychopharmacology1997182
32Inhibition of Smoothened Signaling Prevents Ultraviolet B-Induced Basal Cell Carcinomas through Regulation of Fas Expression and ApoptosisCancer Research2004170
33Intracellular recordings from morphologically identified neurons of the basolateral amygdalaJournal of Neurophysiology1993163
34Direct Activation of Bax Protein for Cancer TherapyMedicinal Research Reviews2016160
35Catechol-O-methyltransferase-catalyzed rapid O-methylation of mutagenic flavonoids. Metabolic inactivation as a possible reason for their lack of carcinogenicity in vivoJournal of Biological Chemistry1994160
36Excitatory transmission in the basolateral amygdalaJournal of Neurophysiology1991157
37Midazolam Oxidation by Cytochrome P450 3A4 and Active-Site Mutants: an Evaluation of Multiple Binding Sites and of the Metabolic Pathway That Leads to Enzyme InactivationMolecular Pharmacology2002156
38Cell Cycle-dependent Subcellular Localization of Exchange Factor Directly Activated by cAMPJournal of Biological Chemistry2002156
39Dopamine D1 and D2 mediation of the discriminative stimulus properties ofd-amphetamine and cocainePsychopharmacology1991155
40Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interactionCell Research2017153
41Loss of Kainate Receptor-Mediated Heterosynaptic Facilitation of Mossy-Fiber Synapses in KA2−/−MiceJournal of Neuroscience2003151
42Neuropharmacology of Phencyclidine: Basic Mechanisms and Therapeutic PotentialAnnual Review of Pharmacology and Toxicology1990150
43Molecular targeting therapies for neuroblastoma: Progress and challengesMedicinal Research Reviews2021150
44Chronic cocaine enhances serotonin autoregulation and serotonin uptake bindingSynapse1992148
45Structure of Microsomal Cytochrome P450 2B4 Complexed with the Antifungal Drug BifonazoleJournal of Biological Chemistry2006148
46Metabotropic glutamate receptors are required for the induction of long-term potentiationNeuron1992147
47Analysis of Mammalian Cytochrome P450 Structure and Function by Site-Directed MutagenesisCurrent Drug Metabolism2001146
48Monoamine reuptake inhibitors enhance the discriminative state induced by cocaine in the ratPsychopharmacology1991142
49Influence of ovarian hormones and estrous cycle on the behavioral response to cocaine in female ratsJournal of Pharmacology and Experimental Therapeutics2000142
50Microsome-mediated 8-hydroxylation of guanine bases of DNA by steroid estrogens: correlation of DNA damage by free radicals with metabolic activation to quinonesCarcinogenesis1995141