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| Protein group modification and synergy in the SUMO pathway as exemplified in DNA repair | Cell | 2012 | 331 |
| Focused ion beam micromachining of eukaryotic cells for cryoelectron tomography | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 260 |
| Dynein achieves processive motion using both stochastic and coordinated stepping | Nature Structural and Molecular Biology | 2012 | 159 |
| Genome-wide measurement of RNA folding energies | Molecular Cell | 2012 | 156 |
| Architecture and function of IFT complex proteins in ciliogenesis | Differentiation | 2012 | 136 |
| Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 128 |
| Structural basis of human DNA polymerase η-mediated chemoresistance to cisplatin | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 126 |
| Automated segmentation of electron tomograms for a quantitative description of actin filament networks | Journal of Structural Biology | 2012 | 122 |
| Genomic content of uncultured Bacteroidetes from contrasting oceanic provinces in the North Atlantic Ocean | Environmental Microbiology | 2012 | 119 |
| The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 118 |
| Structural and functional organization of the Ska complex, a key component of the kinetochore-microtubule interface | Molecular Cell | 2012 | 115 |
| Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction | Journal of Cell Biology | 2012 | 106 |
| Architecture of the nuclease module of the yeast Ccr4-not complex: the Not1-Caf1-Ccr4 interaction | Molecular Cell | 2012 | 105 |
| Conformational switching of the molecular chaperone Hsp90 via regulated phosphorylation | Molecular Cell | 2012 | 96 |
| Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 93 |
| Electron Microscopy of Biological Materials at the Nanometer Scale | Annual Review of Materials Research | 2012 | 91 |
| Toward the prognostic significance and therapeutic potential of HER3 receptor tyrosine kinase in human colon cancer | Clinical Cancer Research | 2012 | 88 |
| FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation | Blood | 2012 | 80 |
| Structures of lysenin reveal a shared evolutionary origin for pore-forming proteins and its mode of sphingomyelin recognition | Structure | 2012 | 75 |
| H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization | Nucleic Acids Research | 2012 | 71 |
| Dual phosphoproteomics and chemical proteomics analysis of erlotinib and gefitinib interference in acute myeloid leukemia cells | Journal of Proteomics | 2012 | 64 |
| Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1 | Cell | 2012 | 62 |
| Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1 | Angewandte Chemie - International Edition | 2012 | 60 |
| Combinatorial treatment of mammospheres with trastuzumab and salinomycin efficiently targets HER2-positive cancer cells and cancer stem cells | International Journal of Cancer | 2012 | 59 |
