ALTEX: Alternatives To Animal Experimentation

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#	Title	Journal	Year	Citations
1	The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation	ALTEX: Alternatives To Animal Experimentation	2009	579
2	Serum-free cell culture: the serum-free media interactive online database	ALTEX: Alternatives To Animal Experimentation	2010	287
3	Fetal bovine serum (FBS): Past – present – future	ALTEX: Alternatives To Animal Experimentation	2018	231
4	Alternatives to the use of fetal bovine serum: serum-free cell culture	ALTEX: Alternatives To Animal Experimentation	2003	228
5	Towards an alternative for the acute fish LC(50) test in chemical assessment: the fish embryo toxicity test goes multi-species -- an update	ALTEX: Alternatives To Animal Experimentation	2005	225
6	Replacement, reduction and refinement	ALTEX: Alternatives To Animal Experimentation	2002	218
7	Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing	ALTEX: Alternatives To Animal Experimentation	2016	214
8	Pancreatic beta cell lines and their applications in diabetes mellitus research	ALTEX: Alternatives To Animal Experimentation	2010	203
9	A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity	ALTEX: Alternatives To Animal Experimentation	2017	195
10	A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing	ALTEX: Alternatives To Animal Experimentation	2012	190
11	Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals - a report by the Transatlantic Think Tank for Toxicology (t4)	ALTEX: Alternatives To Animal Experimentation	2009	187
12	State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology	ALTEX: Alternatives To Animal Experimentation	2014	166
13	Alternatives to the use of fetal bovine serum: human platelet lysates as a serum substitute in cell culture media	ALTEX: Alternatives To Animal Experimentation	2011	164
14	Metabolomics in toxicology and preclinical research	ALTEX: Alternatives To Animal Experimentation	2013	164
15	Look back in anger – what clinical studies tell us about preclinical work	ALTEX: Alternatives To Animal Experimentation	2013	160
16	Toward Good Read-Across Practice (GRAP) guidance	ALTEX: Alternatives To Animal Experimentation	2016	134
17	The US Federal Tox21 Program: A strategic and operational plan for continued leadership	ALTEX: Alternatives To Animal Experimentation	2018	134
18	Integrated testing strategies for safety assessments	ALTEX: Alternatives To Animal Experimentation	2013	133
19	On mapping the human toxome	ALTEX: Alternatives To Animal Experimentation	2011	125
20	Biology-inspired microphysiological systems to advance medicines for patient benefit and animal welfare	ALTEX: Alternatives To Animal Experimentation	2020	123
21	Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity	ALTEX: Alternatives To Animal Experimentation	2018	121
22	Perspectives on validation of high-throughput assays supporting 21st century toxicity testing	ALTEX: Alternatives To Animal Experimentation	2013	118
23	Consensus report on the future of animal-free systemic toxicity testing	ALTEX: Alternatives To Animal Experimentation	2014	113
24	Infectability of Human BrainSphere Neurons Suggests Neurotropism of SARS-CoV-2*	ALTEX: Alternatives To Animal Experimentation	2020	112
25	The dawning of a new age of toxicology	ALTEX: Alternatives To Animal Experimentation	2008	111
26	Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology	ALTEX: Alternatives To Animal Experimentation	2015	108
27	Animal testing and its alternatives – the most important omics is economics	ALTEX: Alternatives To Animal Experimentation	2018	105
28	Developmental neurotoxicity – Challenges in the 21st Century and In Vitro Opportunities	ALTEX: Alternatives To Animal Experimentation	2014	103
29	State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology	ALTEX: Alternatives To Animal Experimentation	2014	101
30	Alternatives to animal experimentation in basic research	ALTEX: Alternatives To Animal Experimentation	2004	101
31	Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation	ALTEX: Alternatives To Animal Experimentation	2012	101
32	Alternatives to the use of fetal bovine serum: Serum-free cell culture	ALTEX: Alternatives To Animal Experimentation	2003	100
33	Animal models of Alzheimer disease: historical pitfalls and a path forward	ALTEX: Alternatives To Animal Experimentation	2014	95
34	Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use	ALTEX: Alternatives To Animal Experimentation	2017	94
35	From pathways to people: applying the adverse outcome pathway (AOP) for skin sensitization to risk assessment	ALTEX: Alternatives To Animal Experimentation	2013	91
36	Read-across approaches - misconceptions, promises and challenges ahead	ALTEX: Alternatives To Animal Experimentation	2014	90
37	DarT: The embryo test with the Zebrafish Danio rerio--a general model in ecotoxicology and toxicology	ALTEX: Alternatives To Animal Experimentation	2002	90
38	Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals	ALTEX: Alternatives To Animal Experimentation	2011	88
39	Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems	ALTEX: Alternatives To Animal Experimentation	2018	87
40	The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans	ALTEX: Alternatives To Animal Experimentation	2012	87
41	Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing	ALTEX: Alternatives To Animal Experimentation	2010	83
42	Good Cell Culture Practice for stem cells and stem-cell-derived models	ALTEX: Alternatives To Animal Experimentation	2017	81
43	Food for thought … on the evolution of toxicology and the phasing out of animal testing	ALTEX: Alternatives To Animal Experimentation	2008	81
44	Food for thought … on in silico methods in toxicology	ALTEX: Alternatives To Animal Experimentation	2009	81
45	Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals	ALTEX: Alternatives To Animal Experimentation	0	81
46	Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier	ALTEX: Alternatives To Animal Experimentation	2016	80
47	Current standing and future prospects for the technologies proposed to transform toxicity testing in the 21st century	ALTEX: Alternatives To Animal Experimentation	2011	79
48	Supporting read-across using biological data	ALTEX: Alternatives To Animal Experimentation	2016	78
49	Integrating non-animal test information into an adaptive testing strategy – skin sensitization proof of concept case	ALTEX: Alternatives To Animal Experimentation	2011	78
50	A first vascularized skin equivalent for as an alternative to animal experimentation	ALTEX: Alternatives To Animal Experimentation	2016	77

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ALTEX: Alternatives To Animal Experimentation

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