# | Title | Journal | Year | Citations |
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1 | Factors That Can Affect the External Validity of Randomised Controlled Trials | PLOS Clinical Trials | 2006 | 291 |
2 | Tenofovir Disoproxil Fumarate for Prevention of HIV Infection in Women: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial | PLOS Clinical Trials | 2007 | 233 |
3 | Cardiovascular and Cerebrovascular Events in the Randomized, Controlled Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT) | PLOS Clinical Trials | 2006 | 165 |
4 | Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for Treatment of Malaria: A Randomized Trial | PLOS Clinical Trials | 2007 | 128 |
5 | A Phase 2b Randomised Trial of the Candidate Malaria Vaccines FP9 ME-TRAP and MVA ME-TRAP among Children in Kenya | PLOS Clinical Trials | 2006 | 124 |
6 | Randomized Dose-Ranging Controlled Trial of AQ-13, a Candidate Antimalarial, and Chloroquine in Healthy Volunteers | PLOS Clinical Trials | 2007 | 112 |
7 | Evolution and Translation of Research Findings: From Bench to Where | PLOS Clinical Trials | 2006 | 106 |
8 | Artemisinin Combination Therapies for Treatment of Uncomplicated Malaria in Uganda | PLOS Clinical Trials | 2006 | 104 |
9 | Volume Expansion with Albumin Compared to Gelofusine in Children with Severe Malaria: Results of a Controlled Trial | PLOS Clinical Trials | 2006 | 97 |
10 | Three Drug Combinations for Late-Stage Trypanosoma brucei gambiense Sleeping Sickness: A Randomized Clinical Trial in Uganda | PLOS Clinical Trials | 2006 | 79 |
11 | Gametocytaemia after Drug Treatment of Asymptomatic Plasmodium falciparum | PLOS Clinical Trials | 2006 | 77 |
12 | Effect of Physical Inactivity on the Oxidation of Saturated and Monounsaturated Dietary Fatty Acids: Results of a Randomized Trial | PLOS Clinical Trials | 2006 | 74 |
13 | Chloroquine/Sulphadoxine-Pyrimethamine for Gambian Children with Malaria: Transmission to Mosquitoes of Multidrug-Resistant Plasmodium falciparum | PLOS Clinical Trials | 2006 | 71 |
14 | Phase 1 Study of Two Merozoite Surface Protein 1 (MSP142) Vaccines for Plasmodium falciparum Malaria | PLOS Clinical Trials | 2007 | 71 |
15 | RTS,S/AS02A Malaria Vaccine Does Not Induce Parasite CSP T Cell Epitope Selection and Reduces Multiplicity of Infection | PLOS Clinical Trials | 2006 | 70 |
16 | A Cluster-Randomised Trial Evaluating an Intervention for Patients with Stress-Related Mental Disorders and Sick Leave in Primary Care | PLOS Clinical Trials | 2007 | 65 |
17 | Safety and Allele-Specific Immunogenicity of a Malaria Vaccine in Malian Adults: Results of a Phase I Randomized Trial | PLOS Clinical Trials | 2006 | 64 |
18 | Genetic Polymorphisms and Weight Loss in Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets | PLOS Clinical Trials | 2006 | 62 |
19 | When and How Can Endpoints Be Changed after Initiation of a Randomized Clinical Trial | PLOS Clinical Trials | 2007 | 62 |
20 | Long-Term Impact of Malaria Chemoprophylaxis on Cognitive Abilities and Educational Attainment: Follow-Up of a Controlled Trial | PLOS Clinical Trials | 2006 | 59 |
21 | Safety and Reactogenicity of an MSP-1 Malaria Vaccine Candidate: A Randomized Phase Ib Dose-Escalation Trial in Kenyan Children | PLOS Clinical Trials | 2006 | 59 |
22 | Secondary Outcomes of a Pilot Randomized Trial of Azithromycin Treatment for Asthma | PLOS Clinical Trials | 2006 | 56 |
23 | The Effects on Saturated Fat Purchases of Providing Internet Shoppers with Purchase- Specific Dietary Advice: A Randomised Trial | PLOS Clinical Trials | 2006 | 53 |
24 | Factors in AIDS Dementia Complex Trial Design: Results and Lessons from the Abacavir Trial | PLOS Clinical Trials | 2007 | 46 |
25 | The Clinical Trials Directive: How Is It Affecting Europe's Noncommercial Research | PLOS Clinical Trials | 2006 | 40 |
26 | A Randomized, Double-Blind, Placebo-Controlled Trial of Lessertia frutescens in Healthy Adults | PLOS Clinical Trials | 2007 | 37 |
27 | A Cluster Randomized Clinical Trial to Improve Prescribing Patterns in Ambulatory Pediatrics | PLOS Clinical Trials | 2007 | 35 |
28 | Randomised Trial of Chloroquine/Sulphadoxine-Pyrimethamine in Gambian Children with Malaria: Impact against Multidrug-Resistant P. falciparum | PLOS Clinical Trials | 2006 | 34 |
29 | A Randomized Controlled Trial of Folate Supplementation When Treating Malaria in Pregnancy with Sulfadoxine-Pyrimethamine | PLOS Clinical Trials | 2006 | 32 |
30 | Can Biomarkers Identify Women at Increased Stroke Risk? The Women's Health Initiative Hormone Trials | PLOS Clinical Trials | 2007 | 31 |
31 | Principles for Strengthening the Integrity of Clinical Research | PLOS Clinical Trials | 2006 | 28 |
32 | Patient Safety Requires a New Way to Publish Clinical Trials | PLOS Clinical Trials | 2006 | 27 |
33 | Intermittent Intravaginal Antibiotic Treatment of Bacterial Vaginosis in HIV-Uninfected and -Infected Women: A Randomized Clinical Trial | PLOS Clinical Trials | 2007 | 27 |
34 | Efficacy of Antioxidant Treatment in Reducing Resistin Serum Levels: A Randomized Study | PLOS Clinical Trials | 2007 | 27 |
35 | A Randomised Trial Comparing Genotypic and Virtual Phenotypic Interpretation of HIV Drug Resistance: The CREST Study | PLOS Clinical Trials | 2006 | 26 |
36 | Effect of Folic Acid and Betaine Supplementation on Flow-Mediated Dilation: A Randomized, Controlled Study in Healthy Volunteers | PLOS Clinical Trials | 2006 | 26 |
37 | Operational Challenges in Large Clinical Trials: Examples and Lessons Learned from the Gambia Pneumococcal Vaccine Trial | PLOS Clinical Trials | 2006 | 26 |
38 | A Randomised Trial of Subcutaneous Intermittent Interleukin-2 without Antiretroviral Therapy in HIV-Infected Patients: The UK–Vanguard Study | PLOS Clinical Trials | 2006 | 19 |
39 | ADAPT: The Wrong Way to Stop a Clinical Trial | PLOS Clinical Trials | 2006 | 17 |
40 | Stimulatory Effect of Morning Bright Light on Reproductive Hormones and Ovulation: Results of a Controlled Crossover Trial | PLOS Clinical Trials | 2007 | 17 |
41 | The Effect of Acclydine in Chronic Fatigue Syndrome: A Randomized Controlled Trial | PLOS Clinical Trials | 2007 | 16 |
42 | Randomised Controlled Trial of Unsolicited Occupational Therapy in Community-Dwelling Elderly People: The LOTIS Trial | PLOS Clinical Trials | 2006 | 15 |
43 | Recovery after Minor Traffic Injuries: A Randomized Controlled Trial | PLOS Clinical Trials | 2007 | 14 |
44 | Publishing Clinical Trial Results: The Future Beckons | PLOS Clinical Trials | 2006 | 13 |
45 | The Suspension of Treatments in ADAPT: Concerns beyond the Cardiovascular Safety of Celecoxib or Naproxen | PLOS Clinical Trials | 2006 | 13 |
46 | Effects of Growth Hormone and Pioglitazone in Viscerally Obese Adults with Impaired Glucose Tolerance: A Factorial Clinical Trial | PLOS Clinical Trials | 2007 | 13 |
47 | Short-Term Efficacy of Rofecoxib and Diclofenac in Acute Shoulder Pain: A Placebo-Controlled Randomized Trial | PLOS Clinical Trials | 2007 | 11 |
48 | Quality of Life in HIV Clinical Trials: Why Sexual Health Must Not Be Ignored | PLOS Clinical Trials | 2007 | 11 |
49 | Immunotherapy with Canarypox Vaccine and Interleukin-2 for HIV-1 Infection: Termination of a Randomized Trial | PLOS Clinical Trials | 2007 | 11 |
50 | Rifampicin/Cotrimoxazole/Isoniazid Versus Mefloquine or Quinine + Sulfadoxine- Pyrimethamine for Malaria: A Randomized Trial | PLOS Clinical Trials | 2006 | 10 |