| # | Title | Journal | Year | Citations |
|---|
| 1 | NF-κB signaling in inflammation | Signal Transduction and Targeted Therapy | 2017 | 4,812 |
| 2 | The role of MicroRNAs in human cancer | Signal Transduction and Targeted Therapy | 2016 | 1,695 |
| 3 | Controlled drug delivery vehicles for cancer treatment and their performance | Signal Transduction and Targeted Therapy | 2018 | 1,386 |
| 4 | Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects | Signal Transduction and Targeted Therapy | 2020 | 1,354 |
| 5 | Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study | Signal Transduction and Targeted Therapy | 2020 | 1,233 |
| 6 | Molecular principles of metastasis: a hallmark of cancer revisited | Signal Transduction and Targeted Therapy | 2020 | 1,075 |
| 7 | Targeting cancer stem cell pathways for cancer therapy | Signal Transduction and Targeted Therapy | 2020 | 998 |
| 8 | Comprehensive review of targeted therapy for colorectal cancer | Signal Transduction and Targeted Therapy | 2020 | 853 |
| 9 | Pyroptosis: mechanisms and diseases | Signal Transduction and Targeted Therapy | 2021 | 821 |
| 10 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells | Signal Transduction and Targeted Therapy | 2020 | 806 |
| 11 | Inflammation and tumor progression: signaling pathways and targeted intervention | Signal Transduction and Targeted Therapy | 2021 | 739 |
| 12 | The role of m6A modification in the biological functions and diseases | Signal Transduction and Targeted Therapy | 2021 | 718 |
| 13 | Therapeutic siRNA: state of the art | Signal Transduction and Targeted Therapy | 2020 | 674 |
| 14 | Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study | Signal Transduction and Targeted Therapy | 2020 | 669 |
| 15 | The JAK/STAT signaling pathway: from bench to clinic | Signal Transduction and Targeted Therapy | 2021 | 636 |
| 16 | Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials | Signal Transduction and Targeted Therapy | 2019 | 618 |
| 17 | Small molecules in targeted cancer therapy: advances, challenges, and future perspectives | Signal Transduction and Targeted Therapy | 2021 | 607 |
| 18 | Exosomes: key players in cancer and potential therapeutic strategy | Signal Transduction and Targeted Therapy | 2020 | 568 |
| 19 | The updated landscape of tumor microenvironment and drug repurposing | Signal Transduction and Targeted Therapy | 2020 | 563 |
| 20 | Targeting oncogenic Myc as a strategy for cancer treatment | Signal Transduction and Targeted Therapy | 2018 | 558 |
| 21 | A mouse model for SARS-CoV-2-induced acute respiratory distress syndrome | Signal Transduction and Targeted Therapy | 2021 | 558 |
| 22 | COVID-19: immunopathogenesis and Immunotherapeutics | Signal Transduction and Targeted Therapy | 2020 | 535 |
| 23 | Viral vector platforms within the gene therapy landscape | Signal Transduction and Targeted Therapy | 2021 | 514 |
| 24 | Pattern recognition receptors in health and diseases | Signal Transduction and Targeted Therapy | 2021 | 510 |
| 25 | Ferroptosis: mechanisms and links with diseases | Signal Transduction and Targeted Therapy | 2021 | 508 |
| 26 | Microbiota in health and diseases | Signal Transduction and Targeted Therapy | 2022 | 494 |
| 27 | Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2 | Signal Transduction and Targeted Therapy | 2020 | 486 |
| 28 | DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer | Signal Transduction and Targeted Therapy | 2020 | 474 |
| 29 | Therapeutic peptides: current applications and future directions | Signal Transduction and Targeted Therapy | 2022 | 454 |
| 30 | Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities | Signal Transduction and Targeted Therapy | 2022 | 446 |
| 31 | The emerging treatment landscape of targeted therapy in non-small-cell lung cancer | Signal Transduction and Targeted Therapy | 2019 | 436 |
| 32 | The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects | Signal Transduction and Targeted Therapy | 2020 | 433 |
| 33 | A systematic review of SARS-CoV-2 vaccine candidates | Signal Transduction and Targeted Therapy | 2020 | 427 |
| 34 | Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets | Signal Transduction and Targeted Therapy | 2021 | 406 |
| 35 | Application of exosomes as liquid biopsy in clinical diagnosis | Signal Transduction and Targeted Therapy | 2020 | 396 |
| 36 | Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials | Signal Transduction and Targeted Therapy | 2020 | 387 |
| 37 | NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential | Signal Transduction and Targeted Therapy | 2020 | 386 |
| 38 | History and progress of hypotheses and clinical trials for Alzheimer’s disease | Signal Transduction and Targeted Therapy | 2019 | 370 |
| 39 | PROTACs: great opportunities for academia and industry | Signal Transduction and Targeted Therapy | 2019 | 367 |
| 40 | Antibody drug conjugate: the “biological missile” for targeted cancer therapy | Signal Transduction and Targeted Therapy | 2022 | 361 |
| 41 | The signal pathways and treatment of cytokine storm in COVID-19 | Signal Transduction and Targeted Therapy | 2021 | 355 |
| 42 | Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles | Signal Transduction and Targeted Therapy | 2019 | 343 |
| 43 | FGF/FGFR signaling in health and disease | Signal Transduction and Targeted Therapy | 2020 | 339 |
| 44 | The role of ubiquitination in tumorigenesis and targeted drug discovery | Signal Transduction and Targeted Therapy | 2020 | 338 |
| 45 | Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development | Signal Transduction and Targeted Therapy | 2021 | 331 |
| 46 | Targeting tumor-associated macrophages to synergize tumor immunotherapy | Signal Transduction and Targeted Therapy | 2021 | 323 |
| 47 | Targeted therapy for hepatocellular carcinoma | Signal Transduction and Targeted Therapy | 2020 | 320 |
| 48 | SARS-CoV-2 Omicron variant: recent progress and future perspectives | Signal Transduction and Targeted Therapy | 2022 | 315 |
| 49 | Targeting PI3K/Akt signal transduction for cancer therapy | Signal Transduction and Targeted Therapy | 2021 | 302 |
| 50 | Targeting macrophages in cancer immunotherapy | Signal Transduction and Targeted Therapy | 2021 | 300 |
