CNS and Neurological Disorders - Drug Targets

2.1(top 20%)

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1.8K(top 10%)

papers

38.8K(top 10%)

citations

83(top 10%)

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2.1(top 20%)

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2.0K

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41.2K

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124(top 10%)

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Top Articles

#	Title	Journal	Year	Citations
1	Gliogenesis and Glial Pathology in Depression	CNS and Neurological Disorders - Drug Targets	2007	510
2	Oxidative Stress and Pathophysiology of Ischemic Stroke: Novel Therapeutic Opportunities	CNS and Neurological Disorders - Drug Targets	2013	487
3	Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease	CNS and Neurological Disorders - Drug Targets	2009	453
4	The Endocannabinoid System and Pain	CNS and Neurological Disorders - Drug Targets	2009	368
5	Assessing Activation States in Microglia	CNS and Neurological Disorders - Drug Targets	2010	347
6	Microglia and Inflammation in Alzheimers Disease	CNS and Neurological Disorders - Drug Targets	2010	346
7	Effects of Exercise on Anxiety and Depression Disorders: Review of Meta- Analyses and Neurobiological Mechanisms	CNS and Neurological Disorders - Drug Targets	2014	306
8	The Dopamine D3 Receptor: A Therapeutic Target for the Treatment of Neuropsychiatric Disorders	CNS and Neurological Disorders - Drug Targets	2006	300
9	Corticotropin Releasing Factor (CRF) Receptor Signaling in the Central Nervous System: New Molecular Targets	CNS and Neurological Disorders - Drug Targets	2006	300
10	The Biology of Neurotrophins, Signalling Pathways, and Functional Peptide Mimetics of Neurotrophins and their Receptors	CNS and Neurological Disorders - Drug Targets	2008	276
11	Disulfiram: An Old Therapeutic with New Applications	CNS and Neurological Disorders - Drug Targets	2010	249
12	Receptor for AGEs (RAGE) as Mediator of NF-kB Pathway Activation in Neuroinflammation and Oxidative Stress	CNS and Neurological Disorders - Drug Targets	2014	226
13	P2X7 Receptors: Channels, Pores and More	CNS and Neurological Disorders - Drug Targets	2012	216
14	Glutamate Receptors as Therapeutic Targets for Parkinsons Disease	CNS and Neurological Disorders - Drug Targets	2009	209
15	Microglia Phenotype Diversity	CNS and Neurological Disorders - Drug Targets	2011	209
16	Status of Acetylcholinesterase and Butyrylcholinesterase in Alzheimer's Disease and Type 2 Diabetes Mellitus	CNS and Neurological Disorders - Drug Targets	2014	209
17	Stress, Depression and Hippocampal Apoptosis	CNS and Neurological Disorders - Drug Targets	2006	201
18	Oxidative Stress: Major Threat in Traumatic Brain Injury	CNS and Neurological Disorders - Drug Targets	2018	196
19	Targeting TNF-Alpha to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative Diseases	CNS and Neurological Disorders - Drug Targets	2011	192
20	The Hypothalamic-Pituitary-Adrenal Axis: What can it Tell us About Stressors?	CNS and Neurological Disorders - Drug Targets	2006	188
21	Ionotropic Glutamate Receptors & CNS Disorders	CNS and Neurological Disorders - Drug Targets	2008	177
22	Tissue Plasminogen Activator (tPA) and Matrix Metalloproteinases in the Pathogenesis of Stroke: Therapeutic Strategies	CNS and Neurological Disorders - Drug Targets	2008	166
23	Drosophila melanogaster in the Study of Human Neurodegeneration	CNS and Neurological Disorders - Drug Targets	2010	165
24	The NMDA Receptor as a Therapeutic Target in Major Depressive Disorder	CNS and Neurological Disorders - Drug Targets	2007	163
25	Dopamine and the Diseased Brain	CNS and Neurological Disorders - Drug Targets	2006	153
26	Cognitive Dysfunction in Major Depressive Disorder: A State-of-the-Art Clinical Review	CNS and Neurological Disorders - Drug Targets	2015	151
27	Mechanisms of Oxidative Glutamate Toxicity: The Glutamate/Cystine Antiporter System xc¯ as a Neuroprotective Drug Target	CNS and Neurological Disorders - Drug Targets	2010	149
28	Dl-3-n-Butylphthalide (NBP): A Promising Therapeutic Agent for Ischemic Stroke	CNS and Neurological Disorders - Drug Targets	2018	145
29	Regulation of Neurogenesis and Gliogenesis by Stress and Antidepressant Treatment	CNS and Neurological Disorders - Drug Targets	2007	139
30	Protein Misfolding and Aggregation in Alzheimer’s Disease and Type 2 Diabetes Mellitus	CNS and Neurological Disorders - Drug Targets	2014	138
31	Inflammatory Mechanisms and Oxidative Stress as Key Factors Responsible for Progression of Neurodegeneration: Role of Brain Innate Immune System	CNS and Neurological Disorders - Drug Targets	2016	138
32	Alzheimer Disease and the Role of Free Radicals in the Pathogenesis of the Disease	CNS and Neurological Disorders - Drug Targets	2008	136
33	Group I Metabotropic Glutamate Receptor Signalling and its Implication in Neurological Disease	CNS and Neurological Disorders - Drug Targets	2010	136
34	Viruses and Multiple Sclerosis	CNS and Neurological Disorders - Drug Targets	2012	135
35	Cannabinoid Receptors and Endocannabinoids: Role in Neuroinflammatory and Neurodegenerative Disorders	CNS and Neurological Disorders - Drug Targets	2010	134
36	Monoamine Oxidase B Inhibitors in Parkinson's Disease	CNS and Neurological Disorders - Drug Targets	2017	134
37	Microglia-Neuron Interaction in Inflammatory and Degenerative Diseases: Role of Cholinergic and Noradrenergic Systems	CNS and Neurological Disorders - Drug Targets	2007	133
38	Chinese Herbs and Herbal Extracts for Neuroprotection of Dopaminergic Neurons and Potential Therapeutic Treatment of Parkinson's Disease	CNS and Neurological Disorders - Drug Targets	2007	132
39	Neuroinflammation, Microglia and Mast Cells in the Pathophysiology of Neurocognitive Disorders: A Review	CNS and Neurological Disorders - Drug Targets	2015	130
40	Metabotropic Glutamate Receptors in the Control of Mood Disorders	CNS and Neurological Disorders - Drug Targets	2007	129
41	The Endocannabinoid System and the Treatment of Mood and Anxiety Disorders	CNS and Neurological Disorders - Drug Targets	2009	128
42	Synaptic Plasticity, Dementia and Alzheimer Disease	CNS and Neurological Disorders - Drug Targets	2017	128
43	Stress and Brain Atrophy	CNS and Neurological Disorders - Drug Targets	2006	123
44	Excitability of Dopamine Neurons: Modulation and Physiological Consequences	CNS and Neurological Disorders - Drug Targets	2006	122
45	Neuronal Death and Survival Under Oxidative Stress in Alzheimer and Parkinson Diseases	CNS and Neurological Disorders - Drug Targets	2007	119
46	In Vitro and In Vivo Models of Multiple Sclerosis	CNS and Neurological Disorders - Drug Targets	2012	119
47	The Involvement of the Vasopressin System in Stress-Related Disorders	CNS and Neurological Disorders - Drug Targets	2006	116
48	Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis sativa	CNS and Neurological Disorders - Drug Targets	2014	116
49	NF-κB as a Key Mediator of Brain Inflammation in Alzheimer’s Disease	CNS and Neurological Disorders - Drug Targets	2019	116
50	Adult Hippocampal Neurogenesis as Target for the Treatment of Depression	CNS and Neurological Disorders - Drug Targets	2007	113

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