Oligonucleotides

2.7(top 20%)

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287(top 50%)

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8.8K(top 20%)

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46(top 20%)

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2.8(top 20%)

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327

all documents

9.1K

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79(top 10%)

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Top Articles

#	Title	Journal	Year	Citations
1	Analysis of Thermal Melting Curves	Oligonucleotides	2003	649
2	Chemical Modification of siRNAs forIn VivoUse	Oligonucleotides	2008	442
3	siRNA and Innate Immunity	Oligonucleotides	2009	362
4	Inhibition of TGF-β2 with AP 12009 in Recurrent Malignant Gliomas: From Preclinical to Phase I/II Studies	Oligonucleotides	2007	209
5	Locked Nucleic Acid: A Potent Nucleic Acid Analog in Therapeutics and Biotechnology	Oligonucleotides	2004	174
6	Cell-Specific Aptamer-Mediated Targeted Drug Delivery	Oligonucleotides	2011	164
7	Development of Single-Stranded DNA Aptamers for Specific Bisphenol A Detection	Oligonucleotides	2011	163
8	Therapeutic Applications of DNA and RNA Aptamers	Oligonucleotides	2009	159
9	Therapeutic Potential of Splice-Switching Oligonucleotides	Oligonucleotides	2009	136
10	Water-Soluble Polycationic Dendrimers with a Phosphoramidothioate Backbone: Preliminary Studies of Cytotoxicity and Oligonucleotide/Plasmid Delivery in Human Cell Culture	Oligonucleotides	2003	113
11	Plasma Protein Binding of an Antisense Oligonucleotide Targeting Human ICAM-1 (ISIS 2302)	Oligonucleotides	2006	113
12	The Translation Start Codon Region Is Sensitive to Antisense PNA Inhibition inEscherichia coli	Oligonucleotides	2003	111
13	Functional Analysis of 114 Exon-Internal AONs for Targeted DMD Exon Skipping: Indication for Steric Hindrance of SR Protein Binding Sites	Oligonucleotides	2005	108
14	Stability Study of Unmodified siRNA and Relevance to Clinical Use	Oligonucleotides	2008	104
15	Bispecific Short Hairpin siRNA Constructs Targeted to CD4, CXCR4, and CCR5 Confer HIV-1 Resistance	Oligonucleotides	2003	103
16	Strategies for Generation of an siRNA Expression Library Directed Against the Human Genome	Oligonucleotides	2003	96
17	Characterization of Therapeutic Oligonucleotides Using Liquid Chromatography with On-line Mass Spectrometry Detection	Oligonucleotides	2003	93
18	Hyaluronic Acid-Modified DOTAP/DOPE Liposomes for the Targeted Delivery of Anti-Telomerase siRNA to CD44-Expressing Lung Cancer Cells	Oligonucleotides	2009	90
19	Selective Protection of Nuclease-Sensitive Sites in siRNA Prolongs Silencing Effect	Oligonucleotides	2009	89
20	Chemical Modification Patterns Compatible with High Potency Dicer-Substrate Small Interfering RNAs	Oligonucleotides	2008	86
21	Advances in Aptamers	Oligonucleotides	2010	83
22	Intracerebral and Intrathecal Infusion of the TGF-β2-Specific Antisense Phosphorothioate Oligonucleotide AP 12009 in Rabbits and Primates: Toxicology and Safety	Oligonucleotides	2005	74
23	Hairpin RNA-Mediated Strategies for Silencing of Tomato Leaf Curl Virus AC1 and AC4 Genes for Effective Resistance in Plants	Oligonucleotides	2007	72
24	Efficient Gene Silencing in Lungs and Liver Using Imidazole-Modified Chitosan As a Nanocarrier for Small Interfering RNA	Oligonucleotides	2010	72
25	Comparison of Different Strategies to Select Aptamers Against a Transmembrane Protein Target	Oligonucleotides	2006	67
26	A Novel Class of Immune-Stimulatory CpG Oligodeoxynucleotides Unifies High Potency in Type I Interferon Induction with Preferred Structural Properties	Oligonucleotides	2010	67
27	Insights into Effective RNAi Gained from Large-Scale siRNA Validation Screening	Oligonucleotides	2007	66
28	Antidote-Controlled Platelet Inhibition Targeting von Willebrand Factor with Aptamers	Oligonucleotides	2007	66
29	Streptavidin-Coated Magnetic Beads for DNA Strand Separation Implicate a Multitude of Problems During Cell-SELEX	Oligonucleotides	2009	64
30	Conjugation to Polyethylene Glycol Polymer Promotes Aptamer Biodistribution to Healthy and Inflamed Tissues	Oligonucleotides	2005	63
31	RNA-Directed Transcriptional Gene Silencing and Activation in Human Cells	Oligonucleotides	2009	63
32	2´-Deoxy Purine, 2´-O-Methyl Pyrimidine (dRmY) Aptamers as Candidate Therapeutics	Oligonucleotides	2006	62
33	Use of siRNAs and Antisense Oligonucleotides Against Survivin RNA to Inhibit Steps Leading to Tumor Angiogenesis	Oligonucleotides	2004	61
34	Simultaneous Generation of Aptamers to Multiple Gamma-Carboxyglutamic Acid Proteins from a Focused Aptamer Library Using DeSELEX and Convergent Selection	Oligonucleotides	2007	59
35	The Biological Effect of an Antisense Oligonucleotide Depends on Its Route of Endocytosis and Trafficking	Oligonucleotides	2010	59
36	Small Interfering RNA Targeting Bcl-2 Sensitizes Malignant Melanoma	Oligonucleotides	2003	56
37	Conserved MicroRNA Characteristics in Mammals	Oligonucleotides	2006	56
38	Induction of Apoptosis in Murine Neuroblastoma by Systemic Delivery of Transferrin-Shielded siRNA Polyplexes for Downregulation of Ran	Oligonucleotides	2008	55
39	shRNAs Targeting Hepatitis C: Effects of Sequence and Structural Features, and Comparision with siRNA	Oligonucleotides	2007	53
40	Tolerance of RNA Interference Toward Modifications of the 5′ Antisense Phosphate of Small Interfering RNA	Oligonucleotides	2007	53
41	Modulation of CpG Oligodeoxynucleotide-Mediated Immune Stimulation by Locked Nucleic Acid (LNA)	Oligonucleotides	2004	51
42	Targeting CCR5 with siRNAs: Using Recombinant SV40-Derived Vectors to Protect Macrophages and Microglia from R5-Tropic HIV	Oligonucleotides	2003	50
43	G3139 and Other CpG-Containing Immunostimulatory Phosphorothioate Oligodeoxynucleotides Are Potent Suppressors of the Growth of Human Tumor Xenografts in Nude Mice	Oligonucleotides	2006	50
44	Modification of Alternative Splicing by Antisense Therapeutics	Oligonucleotides	2004	48
45	Naked siLNA-Mediated Gene Silencing of Lung Bronchoepithelium EGFP Expression After Intravenous Administration	Oligonucleotides	2009	48
46	Bovine and Ovine Blood Mononuclear Leukocytes Differ Markedly in Innate Immune Responses Induced by Class A and Class B CpG-Oligodeoxynucleotide	Oligonucleotides	2003	47
47	Defibrotide, a Polydisperse Mixture of Single-stranded Phosphodiester Oligonucleotides with Lifesaving Activity in Severe Hepatic Veno-occlusive Disease: Clinical Outcomes and Potential Mechanisms of Action	Oligonucleotides	2006	47
48	Molecular Imaging Study on In Vivo Distribution and Pharmacokinetics of Modified Small Interfering RNAs (siRNAs)	Oligonucleotides	2008	47
49	Stem-Loop RT-PCR Quantification of siRNAs In Vitro and In Vivo	Oligonucleotides	2009	47
50	In VitroSelection of RNA Aptamers Against the HCV NS3 Helicase Domain	Oligonucleotides	2004	46

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