| # | Title | Journal | Year | Citations |
|---|
| 1 | Exploration, normalization, and summaries of high density oligonucleotide array probe level data | Biostatistics | 2003 | 9,603 |
| 2 | Adjusting batch effects in microarray expression data using empirical Bayes methods | Biostatistics | 2007 | 6,399 |
| 3 | Sparse inverse covariance estimation with the graphical lasso | Biostatistics | 2008 | 3,943 |
| 4 | Circular binary segmentation for the analysis of array-based DNA copy number data | Biostatistics | 2004 | 1,903 |
| 5 | A penalized matrix decomposition, with applications to sparse principal components and canonical correlation analysis | Biostatistics | 2009 | 1,139 |
| 6 | Small-sample estimation of negative binomial dispersion, with applications to SAGE data | Biostatistics | 2007 | 939 |
| 7 | Estimation of clinical trial success rates and related parameters | Biostatistics | 2019 | 879 |
| 8 | Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures | Biostatistics | 2015 | 878 |
| 9 | Joint modelling of longitudinal measurements and event time data | Biostatistics | 2000 | 698 |
| 10 | Experimental design for gene expression microarrays | Biostatistics | 2001 | 633 |
| 11 | A unification of models for meta-analysis of diagnostic accuracy studies | Biostatistics | 2007 | 593 |
| 12 | Optimal tests for rare variant effects in sequencing association studies | Biostatistics | 2012 | 581 |
| 13 | False discovery rates: a new deal | Biostatistics | 2017 | 561 |
| 14 | Removing technical variability in RNA-seq data using conditional quantile normalization | Biostatistics | 2012 | 532 |
| 15 | Survival ensembles | Biostatistics | 2005 | 529 |
| 16 | Detecting differential gene expression with a semiparametric hierarchical mixture method | Biostatistics | 2004 | 526 |
| 17 | The validation of surrogate endpoints in meta-analyses of randomized experiments | Biostatistics | 2000 | 504 |
| 18 | Frozen robust multiarray analysis (fRMA) | Biostatistics | 2010 | 503 |
| 19 | Regularized linear discriminant analysis and its application in microarrays | Biostatistics | 2007 | 474 |
| 20 | Improved statistical tests for differential gene expression by shrinking variance components estimates | Biostatistics | 2005 | 450 |
| 21 | Missing data and technical variability in single-cell RNA-sequencing experiments | Biostatistics | 2018 | 388 |
| 22 | Monitoring surgical performance using risk-adjusted cumulative sum charts | Biostatistics | 2000 | 371 |
| 23 | General growth mixture modeling for randomized preventive interventions | Biostatistics | 2002 | 366 |
| 24 | Using control genes to correct for unwanted variation in microarray data | Biostatistics | 2012 | 366 |
| 25 | Meta-analysis, funnel plots and sensitivity analysis | Biostatistics | 2000 | 360 |
| 26 | Proper multivariate conditional autoregressive models for spatial data analysis | Biostatistics | 2003 | 346 |
| 27 | Analyzing incomplete longitudinal clinical trial data | Biostatistics | 2004 | 343 |
| 28 | A method for calling gains and losses in array CGH data | Biostatistics | 2005 | 337 |
| 29 | Penalized logistic regression for detecting gene interactions | Biostatistics | 2008 | 314 |
| 30 | Normalization, testing, and false discovery rate estimation for RNA-sequencing data | Biostatistics | 2012 | 308 |
| 31 | Penalized loss functions for Bayesian model comparison | Biostatistics | 2008 | 305 |
| 32 | Classification of gene microarrays by penalized logistic regression | Biostatistics | 2004 | 304 |
| 33 | Quantile regression for longitudinal data using the asymmetric Laplace distribution | Biostatistics | 2007 | 304 |
| 34 | On the bias produced by quality scores in meta-analysis, and a hierarchical view of proposed solutions | Biostatistics | 2001 | 302 |
| 35 | Estimating marginal and incremental effects on health outcomes using flexible link and variance function models | Biostatistics | 2005 | 302 |
| 36 | Assessing the effect of an influenza vaccine in an encouragement design | Biostatistics | 2000 | 282 |
| 37 | Methods that remove batch effects while retaining group differences may lead to exaggerated confidence in downstream analyses | Biostatistics | 2016 | 268 |
| 38 | Spatial smoothing and hot spot detection for CGH data using the fused lasso | Biostatistics | 2008 | 262 |
| 39 | A data-analytic strategy for protein biomarker discovery: profiling of high-dimensional proteomic data for cancer detection | Biostatistics | 2003 | 254 |
| 40 | Disease mapping and spatial regression with count data | Biostatistics | 2007 | 250 |
| 41 | Generalized additive distributed lag models: quantifying mortality displacement | Biostatistics | 2000 | 246 |
| 42 | Combining diagnostic test results to increase accuracy | Biostatistics | 2000 | 241 |
| 43 | Exploration, normalization, and genotype calls of high-density oligonucleotide SNP array data | Biostatistics | 2007 | 214 |
| 44 | The efficiency of pooling mRNA in microarray experiments | Biostatistics | 2003 | 211 |
| 45 | A new shrinkage estimator for dispersion improves differential expression detection in RNA-seq data | Biostatistics | 2013 | 210 |
| 46 | Linear regression analysis of censored medical costs | Biostatistics | 2000 | 206 |
| 47 | Bayesian inference for generalized linear mixed models | Biostatistics | 2010 | 205 |
| 48 | On the equivalence of case-crossover and time series methods in environmental epidemiology | Biostatistics | 2007 | 204 |
| 49 | Estimating and modeling the cure fraction in population-based cancer survival analysis | Biostatistics | 2007 | 201 |
| 50 | Reproducible research and Biostatistics | Biostatistics | 2009 | 198 |
