| # | Title | Journal | Year | Citations |
|---|
| 1 | The amyloid hypothesis of Alzheimer's disease at 25 years | EMBO Molecular Medicine | 2016 | 4,226 |
| 2 | MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review | EMBO Molecular Medicine | 2012 | 1,481 |
| 3 | Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment | EMBO Molecular Medicine | 2011 | 694 |
| 4 | Epithelial‐mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients | EMBO Molecular Medicine | 2014 | 612 |
| 5 | Angiotensin II revisited: new roles in inflammation, immunology and aging | EMBO Molecular Medicine | 2010 | 595 |
| 6 | Resolution of inflammation: an integrated view | EMBO Molecular Medicine | 2013 | 586 |
| 7 | Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors | EMBO Molecular Medicine | 2009 | 582 |
| 8 | Inflammation and EMT: an alliance towards organ fibrosis and cancer progression | EMBO Molecular Medicine | 2009 | 557 |
| 9 | Development of microRNA therapeutics is coming of age | EMBO Molecular Medicine | 2014 | 526 |
| 10 | Disease‐specific phenotypes in dopamine neurons from human iPS‐based models of genetic and sporadic Parkinson's disease | EMBO Molecular Medicine | 2012 | 501 |
| 11 | Inflammasomes in neuroinflammatory and neurodegenerative diseases | EMBO Molecular Medicine | 2019 | 457 |
| 12 | Biology, detection, and clinical implications of circulating tumor cells | EMBO Molecular Medicine | 2015 | 453 |
| 13 | Human colon cancer epithelial cells harbour active HEDGEHOG‐GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion | EMBO Molecular Medicine | 2009 | 430 |
| 14 | Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism | EMBO Molecular Medicine | 2010 | 417 |
| 15 | Alteration of the micro RNA network during the progression of Alzheimer's disease | EMBO Molecular Medicine | 2013 | 408 |
| 16 | Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer | EMBO Molecular Medicine | 2012 | 403 |
| 17 | Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection | EMBO Molecular Medicine | 2011 | 401 |
| 18 | Clinical development of CAR T cells—challenges and opportunities in translating innovative treatment concepts | EMBO Molecular Medicine | 2017 | 397 |
| 19 | sTREM 2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers | EMBO Molecular Medicine | 2016 | 392 |
| 20 | Fc‐fusion proteins: new developments and future perspectives | EMBO Molecular Medicine | 2012 | 382 |
| 21 | Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease | EMBO Molecular Medicine | 2015 | 380 |
| 22 | Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine | EMBO Molecular Medicine | 2010 | 370 |
| 23 | The role of the microbiome in NAFLD and NASH | EMBO Molecular Medicine | 2019 | 368 |
| 24 | Balancing the fat: lipid droplets and human disease | EMBO Molecular Medicine | 2013 | 367 |
| 25 | Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function | EMBO Molecular Medicine | 2009 | 360 |
| 26 | Genetically engineered mouse models in oncology research and cancer medicine | EMBO Molecular Medicine | 2017 | 356 |
| 27 | SIRT1 and SIRT2: emerging targets in neurodegeneration | EMBO Molecular Medicine | 2013 | 352 |
| 28 | MicroRNA‐146 represses endothelial activation by inhibiting pro‐inflammatory pathways | EMBO Molecular Medicine | 2013 | 352 |
| 29 | Investigating the zoonotic origin of the West African Ebola epidemic | EMBO Molecular Medicine | 2015 | 347 |
| 30 | Vaccines for the 21st century | EMBO Molecular Medicine | 2014 | 342 |
| 31 | Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration | EMBO Molecular Medicine | 2015 | 340 |
| 32 | The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance | EMBO Molecular Medicine | 2013 | 337 |
| 33 | Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3 | EMBO Molecular Medicine | 2014 | 326 |
| 34 | Tranilast directly targets NLRP 3 to treat inflammasome‐driven diseases | EMBO Molecular Medicine | 2018 | 325 |
| 35 | A serum circulating miRNA diagnostic test to identify asymptomatic high‐risk individuals with early stage lung cancer | EMBO Molecular Medicine | 2011 | 322 |
| 36 | Cerebrospinal fluid tau and ptau 181 increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's disease | EMBO Molecular Medicine | 2009 | 315 |
| 37 | Towards a new combination therapy for tuberculosis with next generation benzothiazinones | EMBO Molecular Medicine | 2014 | 311 |
| 38 | Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology | EMBO Molecular Medicine | 2015 | 310 |
| 39 | Oxaliplatin‐induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors | EMBO Molecular Medicine | 2011 | 304 |
| 40 | Dantrolene rescues arrhythmogenic RYR2 defect in a patient‐specific stem cell model of catecholaminergic polymorphic ventricular tachycardia | EMBO Molecular Medicine | 2012 | 298 |
| 41 | Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB | EMBO Molecular Medicine | 2014 | 297 |
| 42 | A ntimicrobial peptides and gut microbiota in homeostasis and pathology | EMBO Molecular Medicine | 2013 | 293 |
| 43 | The role of interleukin‐6 in monitoring severe case of coronavirus disease 2019 | EMBO Molecular Medicine | 2020 | 293 |
| 44 | Regulatory T‐lymphocytes mediate amyotrophic lateral sclerosis progression and survival | EMBO Molecular Medicine | 2013 | 289 |
| 45 | Emerging treatment strategies for glioblastoma multiforme | EMBO Molecular Medicine | 2014 | 280 |
| 46 | FGF23 regulates renal sodium handling and blood pressure | EMBO Molecular Medicine | 2014 | 275 |
| 47 | Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease | EMBO Molecular Medicine | 2013 | 273 |
| 48 | Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease | EMBO Molecular Medicine | 2013 | 270 |
| 49 | Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart | EMBO Molecular Medicine | 2013 | 268 |
| 50 | Sox2 promotes tamoxifen resistance in breast cancer cells | EMBO Molecular Medicine | 2014 | 262 |
