| # | Title | Journal | Year | Citations |
|---|
|
| 1 | The effects of alternate optimal solutions in constraint-based genome-scale metabolic models | Metabolic Engineering | 2003 | 1,111 |
| 2 | Metabolic engineering of Escherichia coli for 1-butanol production | Metabolic Engineering | 2008 | 776 |
| 3 | 13C Metabolic Flux Analysis | Metabolic Engineering | 2001 | 734 |
| 4 | Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production | Metabolic Engineering | 2013 | 584 |
| 5 | Engineering a platform for photosynthetic isoprene production in cyanobacteria, using Synechocystis as the model organism | Metabolic Engineering | 2010 | 545 |
| 6 | From zero to hero—Design-based systems metabolic engineering of Corynebacterium glutamicum for l-lysine production | Metabolic Engineering | 2011 | 540 |
| 7 | Metabolic Fluxes and Metabolic Engineering | Metabolic Engineering | 1999 | 528 |
| 8 | Elementary metabolite units (EMU): A novel framework for modeling isotopic distributions | Metabolic Engineering | 2007 | 522 |
| 9 | A comparative view of metabolite and substrate stress and tolerance in microbial bioprocessing: From biofuels and chemicals, to biocatalysis and bioremediation | Metabolic Engineering | 2010 | 481 |
| 10 | Biorefineries for the production of top building block chemicals and their derivatives | Metabolic Engineering | 2015 | 436 |
| 11 | Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements | Metabolic Engineering | 2006 | 435 |
| 12 | Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli | Metabolic Engineering | 2005 | 423 |
| 13 | Microbial export of lactic and 3-hydroxypropanoic acid: implications for industrial fermentation processes | Metabolic Engineering | 2004 | 411 |
| 14 | Global transcription machinery engineering: A new approach for improving cellular phenotype | Metabolic Engineering | 2007 | 404 |
| 15 | Metabolic Engineering of Fatty Acid Biosynthesis in Plants | Metabolic Engineering | 2002 | 397 |
| 16 | Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli | Metabolic Engineering | 2007 | 392 |
| 17 | Cell-free synthetic biology: Thinking outside the cell | Metabolic Engineering | 2012 | 374 |
| 18 | Synthetic biology and the development of tools for metabolic engineering | Metabolic Engineering | 2012 | 368 |
| 19 | Metabolic engineering of Escherichia coli using CRISPR–Cas9 meditated genome editing | Metabolic Engineering | 2015 | 367 |
| 20 | Multiplex metabolic pathway engineering using CRISPR/Cas9 in Saccharomyces cerevisiae | Metabolic Engineering | 2015 | 363 |
| 21 | Metabolic Engineering of Osmoprotectant Accumulation in Plants | Metabolic Engineering | 2002 | 355 |
| 22 | Metabolic engineering of Escherichia coli for 1-butanol and 1-propanol production via the keto-acid pathways | Metabolic Engineering | 2008 | 355 |
| 23 | Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production | Metabolic Engineering | 2008 | 354 |
| 24 | Engineering alternative butanol production platforms in heterologous bacteria | Metabolic Engineering | 2009 | 354 |
| 25 | Metabolic engineering of cyanobacteria for 1-butanol production from carbon dioxide | Metabolic Engineering | 2011 | 354 |
| 26 | Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production | Metabolic Engineering | 2013 | 353 |
| 27 | Pseudomonas putida as a functional chassis for industrial biocatalysis: From native biochemistry to trans-metabolism | Metabolic Engineering | 2018 | 351 |
| 28 | Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid-derived biofuels and chemicals | Metabolic Engineering | 2014 | 350 |
| 29 | Selection and optimization of microbial hosts for biofuels production | Metabolic Engineering | 2008 | 349 |
| 30 | A Universal Framework for 13C Metabolic Flux Analysis | Metabolic Engineering | 2001 | 348 |
| 31 | Overproduction of free fatty acids in E. coli: Implications for biodiesel production | Metabolic Engineering | 2008 | 344 |
| 32 | Chlamydomonas starchless mutant defective in ADP-glucose pyrophosphorylase hyper-accumulates triacylglycerol | Metabolic Engineering | 2010 | 341 |
| 33 | The emergence of adaptive laboratory evolution as an efficient tool for biological discovery and industrial biotechnology | Metabolic Engineering | 2019 | 339 |
| 34 | Deleting the para-nitrophenyl phosphatase (pNPPase), PHO13, in recombinant Saccharomyces cerevisiae improves growth and ethanol production on d-xylose | Metabolic Engineering | 2008 | 334 |
| 35 | Mapping photoautotrophic metabolism with isotopically nonstationary 13C flux analysis | Metabolic Engineering | 2011 | 320 |
| 36 | Kinetic modelling reveals current limitations in the production of ethanol from xylose by recombinant Saccharomyces cerevisiae | Metabolic Engineering | 2011 | 318 |
| 37 | In silico aided metabolic engineering of Saccharomyces cerevisiae for improved bioethanol production | Metabolic Engineering | 2006 | 315 |
| 38 | Engineering of the pyruvate dehydrogenase bypass in Saccharomyces cerevisiae for high-level production of isoprenoids | Metabolic Engineering | 2007 | 310 |
| 39 | Selective reduction of xylose to xylitol from a mixture of hemicellulosic sugars | Metabolic Engineering | 2010 | 310 |
| 40 | Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA | Metabolic Engineering | 2011 | 308 |
| 41 | Heterologous expression of d-xylulokinase from Pichia stipitis enables high levels of xylitol production by engineered Escherichia coli growing on xylose | Metabolic Engineering | 2009 | 307 |
| 42 | An optimization framework for identifying reaction activation/inhibition or elimination candidates for overproduction in microbial systems | Metabolic Engineering | 2006 | 298 |
| 43 | Bioconversion of d-xylose to d-xylonate with Kluyveromyces lactis | Metabolic Engineering | 2011 | 296 |
| 44 | Engineering lipid overproduction in the oleaginous yeast Yarrowia lipolytica | Metabolic Engineering | 2015 | 296 |
| 45 | Optimization of a heterologous pathway for the production of flavonoids from glucose | Metabolic Engineering | 2011 | 280 |
| 46 | Metabolic engineering in methanotrophic bacteria | Metabolic Engineering | 2015 | 280 |
| 47 | The future of metabolic engineering and synthetic biology: Towards a systematic practice | Metabolic Engineering | 2012 | 279 |
| 48 | Metabolic Engineering for Microbial Production of Aromatic Amino Acids and Derived Compounds | Metabolic Engineering | 2001 | 276 |
| 49 | Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene | Metabolic Engineering | 2019 | 276 |
| 50 | Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism | Metabolic Engineering | 2013 | 275 |
