2.2(top 20%)
impact factor
927(top 20%)
papers
20.5K(top 10%)
citations
64(top 10%)
h-index
2.2(top 20%)
impact factor
1.1K
all documents
21.8K
doc citations
101(top 10%)
g-index

Top Articles

#TitleJournalYearCitations
1General pharmacokinetic model for drugs exhibiting target-mediated drug dispositionJournal of Pharmacokinetics and Pharmacodynamics2001501
2Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studiesJournal of Pharmacokinetics and Pharmacodynamics2007411
3Evaluating pharmacokinetic/pharmacodynamic models using the posterior predictive checkJournal of Pharmacokinetics and Pharmacodynamics2001357
4Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and humanJournal of Pharmacokinetics and Pharmacodynamics2012315
5Simultaneous vs. Sequential Analysis for Population PK/PD Data I: Best-Case PerformanceJournal of Pharmacokinetics and Pharmacodynamics2003297
6Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout miceJournal of Pharmacokinetics and Pharmacodynamics2007295
7Likelihood based approaches to handling data below the quantification limit using NONMEM VIJournal of Pharmacokinetics and Pharmacodynamics2008260
8Assessment of actual significance levels for covariate effects in NONMEMJournal of Pharmacokinetics and Pharmacodynamics2001258
9Approximations of the target-mediated drug disposition model and identifiability of model parametersJournal of Pharmacokinetics and Pharmacodynamics2008213
10Development of a Physiology-Based Whole-Body Population Model for Assessing the Influence of Individual Variability on the Pharmacokinetics of DrugsJournal of Pharmacokinetics and Pharmacodynamics2007199
11Improving the estimation of parameter uncertainty distributions in nonlinear mixed effects models using sampling importance resamplingJournal of Pharmacokinetics and Pharmacodynamics2016176
12Extensions to the Visual Predictive Check to facilitate model performance evaluationJournal of Pharmacokinetics and Pharmacodynamics2008171
13Pharmacokinetic–Pharmacodynamic Modelling: History and PerspectivesJournal of Pharmacokinetics and Pharmacodynamics2006147
14Scientific white paper on concentration-QTc modelingJournal of Pharmacokinetics and Pharmacodynamics2018146
15Applications of minimal physiologically-based pharmacokinetic modelsJournal of Pharmacokinetics and Pharmacodynamics2012144
16Modelling Response Time Profiles in the Absence of Drug Concentrations: Definition and Performance Evaluation of the K–PD ModelJournal of Pharmacokinetics and Pharmacodynamics2007141
17Bayesian analysis of population PK/PD models: general concepts and softwareJournal of Pharmacokinetics and Pharmacodynamics2002137
18Estimation of Population Pharmacokinetic Parameters of Saquinavir in HIV Patients with the MONOLIX SoftwareJournal of Pharmacokinetics and Pharmacodynamics2007135
19Power, Selection Bias and Predictive Performance of the Population Pharmacokinetic Covariate ModelJournal of Pharmacokinetics and Pharmacodynamics2004133
20A Mechanism-based Disease Progression Model for Comparison of Long-term Effects of Pioglitazone, Metformin and Gliclazide on Disease Processes Underlying Type 2 Diabetes MellitusJournal of Pharmacokinetics and Pharmacodynamics2006129
21Bench to bedside translation of antibody drug conjugates using a multiscale mechanistic PK/PD model: a case study with brentuximab-vedotinJournal of Pharmacokinetics and Pharmacodynamics2012129
22How Modeling and Simulation Have Enhanced Decision Making in New Drug DevelopmentJournal of Pharmacokinetics and Pharmacodynamics2005127
23Second-generation minimal physiologically-based pharmacokinetic model for monoclonal antibodiesJournal of Pharmacokinetics and Pharmacodynamics2013123
24Lumping of whole-body physiologically based pharmacokinetic modelsJournal of Pharmacokinetics and Pharmacodynamics1998112
25Fifth-generation model for corticosteroid pharmacodynamics: application to steady-state receptor down-regulation and enzyme induction patterns during seven-day continuous infusion of methylprednisolone in ratsJournal of Pharmacokinetics and Pharmacodynamics2002111
26Fractional kinetics in drug absorption and disposition processesJournal of Pharmacokinetics and Pharmacodynamics2009111
27Mechanism-based pharmacokinetic–pharmacodynamic modeling of antimicrobial drug effectsJournal of Pharmacokinetics and Pharmacodynamics2007108
28Modeling the efficacy of trastuzumab-DM1, an antibody drug conjugate, in miceJournal of Pharmacokinetics and Pharmacodynamics2010107
29Model-Based Drug Development: The Road to Quantitative PharmacologyJournal of Pharmacokinetics and Pharmacodynamics2006104
30Use of prior information to stabilize a population data analysisJournal of Pharmacokinetics and Pharmacodynamics2002103
31Time dependent pharmacokinetics of pembrolizumab in patients with solid tumor and its correlation with best overall responseJournal of Pharmacokinetics and Pharmacodynamics2017103
32Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humansJournal of Pharmacokinetics and Pharmacodynamics2010101
33Utility of CSF in translational neuroscienceJournal of Pharmacokinetics and Pharmacodynamics201397
34Prediction Discrepancies for the Evaluation of Nonlinear Mixed-Effects ModelsJournal of Pharmacokinetics and Pharmacodynamics200694
35Derivation of various NONMEM estimation methodsJournal of Pharmacokinetics and Pharmacodynamics200793
36Tracer-kinetic modeling of dynamic contrast-enhanced MRI and CT: a primerJournal of Pharmacokinetics and Pharmacodynamics201393
37In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILIJournal of Pharmacokinetics and Pharmacodynamics201292
38Modeling of tumor growth and anticancer effects of combination therapyJournal of Pharmacokinetics and Pharmacodynamics200991
39Population-Based Analysis of Methadone Distribution and Metabolism Using an Age-Dependent Physiologically Based Pharmacokinetic ModelJournal of Pharmacokinetics and Pharmacodynamics200690
40Estimation of confidence intervals for area under the curve from destructively obtained pharmacokinetic dataJournal of Pharmacokinetics and Pharmacodynamics199887
41Simultaneous vs. Sequential Analysis for Population PK/PD Data II: Robustness of MethodsJournal of Pharmacokinetics and Pharmacodynamics200387
42Non-Linear Mixed Effects Modeling – From Methodology and Software Development to Driving Implementation in Drug Development ScienceJournal of Pharmacokinetics and Pharmacodynamics200587
43A Joint Model for Nonlinear Longitudinal Data with Informative DropoutJournal of Pharmacokinetics and Pharmacodynamics200386
44Disease Progression and Pharmacodynamics in Parkinson Disease – Evidence for Functional Protection with Levodopa and Other TreatmentsJournal of Pharmacokinetics and Pharmacodynamics200686
45Fractional kinetics in multi-compartmental systemsJournal of Pharmacokinetics and Pharmacodynamics201086
46An automated sampling importance resampling procedure for estimating parameter uncertaintyJournal of Pharmacokinetics and Pharmacodynamics201786
47A Genetic Algorithm-Based, Hybrid Machine Learning Approach to Model SelectionJournal of Pharmacokinetics and Pharmacodynamics200684
48Viral kinetic modeling: state of the artJournal of Pharmacokinetics and Pharmacodynamics201482
49Quantitative characterization of in vitro bystander effect of antibody-drug conjugatesJournal of Pharmacokinetics and Pharmacodynamics201681
50Physiologically-based pharmacokinetic models: approaches for enabling personalized medicineJournal of Pharmacokinetics and Pharmacodynamics201679