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Journal of Pharmacokinetics and Pharmacodynamics
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Top Articles
Journal of Pharmacokinetics and Pharmacodynamics
2.2
(top 20%)
impact factor
927
(top 20%)
papers
20.5K
(top 10%)
citations
64
(top 10%)
h
-index
2.2
(top 20%)
impact factor
1.1K
all documents
21.8K
doc citations
101
(top 10%)
g
-index
Top Articles
#
Title
Journal
Year
Citations
1
General pharmacokinetic model for drugs exhibiting target-mediated drug disposition
Journal of Pharmacokinetics and Pharmacodynamics
2001
501
2
Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies
Journal of Pharmacokinetics and Pharmacodynamics
2007
411
3
Evaluating pharmacokinetic/pharmacodynamic models using the posterior predictive check
Journal of Pharmacokinetics and Pharmacodynamics
2001
357
4
Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human
Journal of Pharmacokinetics and Pharmacodynamics
2012
315
5
Simultaneous vs. Sequential Analysis for Population PK/PD Data I: Best-Case Performance
Journal of Pharmacokinetics and Pharmacodynamics
2003
297
6
Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout mice
Journal of Pharmacokinetics and Pharmacodynamics
2007
295
7
Likelihood based approaches to handling data below the quantification limit using NONMEM VI
Journal of Pharmacokinetics and Pharmacodynamics
2008
260
8
Assessment of actual significance levels for covariate effects in NONMEM
Journal of Pharmacokinetics and Pharmacodynamics
2001
258
9
Approximations of the target-mediated drug disposition model and identifiability of model parameters
Journal of Pharmacokinetics and Pharmacodynamics
2008
213
10
Development of a Physiology-Based Whole-Body Population Model for Assessing the Influence of Individual Variability on the Pharmacokinetics of Drugs
Journal of Pharmacokinetics and Pharmacodynamics
2007
199
11
Improving the estimation of parameter uncertainty distributions in nonlinear mixed effects models using sampling importance resampling
Journal of Pharmacokinetics and Pharmacodynamics
2016
176
12
Extensions to the Visual Predictive Check to facilitate model performance evaluation
Journal of Pharmacokinetics and Pharmacodynamics
2008
171
13
Pharmacokinetic–Pharmacodynamic Modelling: History and Perspectives
Journal of Pharmacokinetics and Pharmacodynamics
2006
147
14
Scientific white paper on concentration-QTc modeling
Journal of Pharmacokinetics and Pharmacodynamics
2018
146
15
Applications of minimal physiologically-based pharmacokinetic models
Journal of Pharmacokinetics and Pharmacodynamics
2012
144
16
Modelling Response Time Profiles in the Absence of Drug Concentrations: Definition and Performance Evaluation of the K–PD Model
Journal of Pharmacokinetics and Pharmacodynamics
2007
141
17
Bayesian analysis of population PK/PD models: general concepts and software
Journal of Pharmacokinetics and Pharmacodynamics
2002
137
18
Estimation of Population Pharmacokinetic Parameters of Saquinavir in HIV Patients with the MONOLIX Software
Journal of Pharmacokinetics and Pharmacodynamics
2007
135
19
Power, Selection Bias and Predictive Performance of the Population Pharmacokinetic Covariate Model
Journal of Pharmacokinetics and Pharmacodynamics
2004
133
20
A Mechanism-based Disease Progression Model for Comparison of Long-term Effects of Pioglitazone, Metformin and Gliclazide on Disease Processes Underlying Type 2 Diabetes Mellitus
Journal of Pharmacokinetics and Pharmacodynamics
2006
129
21
Bench to bedside translation of antibody drug conjugates using a multiscale mechanistic PK/PD model: a case study with brentuximab-vedotin
Journal of Pharmacokinetics and Pharmacodynamics
2012
129
22
How Modeling and Simulation Have Enhanced Decision Making in New Drug Development
Journal of Pharmacokinetics and Pharmacodynamics
2005
127
23
Second-generation minimal physiologically-based pharmacokinetic model for monoclonal antibodies
Journal of Pharmacokinetics and Pharmacodynamics
2013
123
24
Lumping of whole-body physiologically based pharmacokinetic models
Journal of Pharmacokinetics and Pharmacodynamics
1998
112
25
Fifth-generation model for corticosteroid pharmacodynamics: application to steady-state receptor down-regulation and enzyme induction patterns during seven-day continuous infusion of methylprednisolone in rats
Journal of Pharmacokinetics and Pharmacodynamics
2002
111
26
Fractional kinetics in drug absorption and disposition processes
Journal of Pharmacokinetics and Pharmacodynamics
2009
111
27
Mechanism-based pharmacokinetic–pharmacodynamic modeling of antimicrobial drug effects
Journal of Pharmacokinetics and Pharmacodynamics
2007
108
28
Modeling the efficacy of trastuzumab-DM1, an antibody drug conjugate, in mice
Journal of Pharmacokinetics and Pharmacodynamics
2010
107
29
Model-Based Drug Development: The Road to Quantitative Pharmacology
Journal of Pharmacokinetics and Pharmacodynamics
2006
104
30
Use of prior information to stabilize a population data analysis
Journal of Pharmacokinetics and Pharmacodynamics
2002
103
31
Time dependent pharmacokinetics of pembrolizumab in patients with solid tumor and its correlation with best overall response
Journal of Pharmacokinetics and Pharmacodynamics
2017
103
32
Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans
Journal of Pharmacokinetics and Pharmacodynamics
2010
101
33
Utility of CSF in translational neuroscience
Journal of Pharmacokinetics and Pharmacodynamics
2013
97
34
Prediction Discrepancies for the Evaluation of Nonlinear Mixed-Effects Models
Journal of Pharmacokinetics and Pharmacodynamics
2006
94
35
Derivation of various NONMEM estimation methods
Journal of Pharmacokinetics and Pharmacodynamics
2007
93
36
Tracer-kinetic modeling of dynamic contrast-enhanced MRI and CT: a primer
Journal of Pharmacokinetics and Pharmacodynamics
2013
93
37
In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI
Journal of Pharmacokinetics and Pharmacodynamics
2012
92
38
Modeling of tumor growth and anticancer effects of combination therapy
Journal of Pharmacokinetics and Pharmacodynamics
2009
91
39
Population-Based Analysis of Methadone Distribution and Metabolism Using an Age-Dependent Physiologically Based Pharmacokinetic Model
Journal of Pharmacokinetics and Pharmacodynamics
2006
90
40
Estimation of confidence intervals for area under the curve from destructively obtained pharmacokinetic data
Journal of Pharmacokinetics and Pharmacodynamics
1998
87
41
Simultaneous vs. Sequential Analysis for Population PK/PD Data II: Robustness of Methods
Journal of Pharmacokinetics and Pharmacodynamics
2003
87
42
Non-Linear Mixed Effects Modeling – From Methodology and Software Development to Driving Implementation in Drug Development Science
Journal of Pharmacokinetics and Pharmacodynamics
2005
87
43
A Joint Model for Nonlinear Longitudinal Data with Informative Dropout
Journal of Pharmacokinetics and Pharmacodynamics
2003
86
44
Disease Progression and Pharmacodynamics in Parkinson Disease – Evidence for Functional Protection with Levodopa and Other Treatments
Journal of Pharmacokinetics and Pharmacodynamics
2006
86
45
Fractional kinetics in multi-compartmental systems
Journal of Pharmacokinetics and Pharmacodynamics
2010
86
46
An automated sampling importance resampling procedure for estimating parameter uncertainty
Journal of Pharmacokinetics and Pharmacodynamics
2017
86
47
A Genetic Algorithm-Based, Hybrid Machine Learning Approach to Model Selection
Journal of Pharmacokinetics and Pharmacodynamics
2006
84
48
Viral kinetic modeling: state of the art
Journal of Pharmacokinetics and Pharmacodynamics
2014
82
49
Quantitative characterization of in vitro bystander effect of antibody-drug conjugates
Journal of Pharmacokinetics and Pharmacodynamics
2016
81
50
Physiologically-based pharmacokinetic models: approaches for enabling personalized medicine
Journal of Pharmacokinetics and Pharmacodynamics
2016
79
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