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Top Articles

#TitleJournalYearCitations
1A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening AssaysJournal of Biomolecular Screening19996,128
2High-Density Miniaturized Thermal Shift Assays as a General Strategy for Drug DiscoveryJournal of Biomolecular Screening2001782
3The Use of 3-D Cultures for High-Throughput Screening: The Multicellular Spheroid ModelJournal of Biomolecular Screening2004689
4Rapid Generation of Single-Tumor Spheroids for High-Throughput Cell Function and Toxicity AnalysisJournal of Biomolecular Screening2006488
5Improved Statistical Methods for Hit Selection in High-Throughput ScreeningJournal of Biomolecular Screening2003306
6Fluorescence Polarization and Anisotropy in High Throughput Screening: Perspectives and PrimerJournal of Biomolecular Screening2000291
7Using Extended-Connectivity Fingerprints with Laplacian-Modified Bayesian Analysis in High-Throughput Screening Follow-UpJournal of Biomolecular Screening2005259
8A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay ParadigmJournal of Biomolecular Screening2016259
9Label-Free Assays on the BIND SystemJournal of Biomolecular Screening2004245
10A Simple Technique for Reducing Edge Effect in Cell-Based AssaysJournal of Biomolecular Screening2003232
11IonWorks™ HT: A New High-Throughput Electrophysiology Measurement PlatformJournal of Biomolecular Screening2003232
12Chagas Disease Drug Discovery: Toward a New EraJournal of Biomolecular Screening2015227
13The Future of High-Throughput ScreeningJournal of Biomolecular Screening2008213
14Development of High Throughput Screening Assays Using Fluorescence Polarization: Nuclear Receptor-Ligand-Binding and Kinase/Phosphatase AssaysJournal of Biomolecular Screening2000212
15High-Content Screening: A New Approach to Easing Key Bottlenecks in the Drug Discovery ProcessJournal of Biomolecular Screening1997208
16A New Bliss Independence Model to Analyze Drug Combination DataJournal of Biomolecular Screening2014207
17A Comparison of Assay Performance Measures in Screening Assays: Signal Window, Z' Factor, and Assay Variability RatioJournal of Biomolecular Screening2006204
18Dynamic Monitoring of Cell Adhesion and Spreading on Microelectronic Sensor ArraysJournal of Biomolecular Screening2005202
19FLIPR: A New Instrument for Accurate, High Throughput Optical ScreeningJournal of Biomolecular Screening1996196
20High Throughput Prediction of Oral Absorption: Improvement of the Composition of the Lipid Solution Used in Parallel Artificial Membrane Permeation AssayJournal of Biomolecular Screening2001191
21Comparison of the Usefulness of the MTT, ATP, and Calcein Assays to Predict the Potency of Cytotoxic Agents in Various Human Cancer Cell LinesJournal of Biomolecular Screening2004189
22High-Throughput Screening: Update on Practices and SuccessJournal of Biomolecular Screening2006189
23High-Throughput Screening of G Protein-Coupled Receptor Antagonists Using a Bioluminescence Resonance Energy Transfer 1-Based β-Arrestin2 Recruitment AssayJournal of Biomolecular Screening2005181
24Fluorescence Polarization Competition Assay: The Range of Resolvable Inhibitor Potency Is Limited by the Affinity of the Fluorescent LigandJournal of Biomolecular Screening2003178
25A Reliable Tool to Determine Cell Viability in Complex 3-D Culture: The Acid Phosphatase AssayJournal of Biomolecular Screening2007178
26Universal Screening Methods and Applications of ThermoFluor®Journal of Biomolecular Screening2006167
27Illustration of SSMD, z Score, SSMD*, z* Score, and t Statistic for Hit Selection in RNAi High-Throughput ScreensJournal of Biomolecular Screening2011166
28Comparison of Methods for Image-Based Profiling of Cellular Morphological Responses to Small-Molecule TreatmentJournal of Biomolecular Screening2013166
29Increasing the Content of High-Content Screening: An OverviewJournal of Biomolecular Screening2014166
30Median Absolute Deviation to Improve Hit Selection for Genome-Scale RNAi ScreensJournal of Biomolecular Screening2008163
31A Thallium-Sensitive, Fluorescence-Based Assay for Detecting and Characterizing Potassium Channel Modulators in Mammalian CellsJournal of Biomolecular Screening2004158
32Characterization of Differentiated SH-SY5Y as Neuronal Screening Model Reveals Increased Oxidative VulnerabilityJournal of Biomolecular Screening2016157
33An AlphaScreen®-Based Assay for High-Throughput Screening for Specific Inhibitors of Nuclear ImportJournal of Biomolecular Screening2011151
34Screening β-Arrestin Recruitment for the Identification of Natural Ligands for Orphan G-Protein–Coupled ReceptorsJournal of Biomolecular Screening2013145
35A Simplified Method for Quantifying Cell Migration/Wound Healing in 96-Well PlatesJournal of Biomolecular Screening2010142
36A Novel Membrane Potential-Sensitive Fluorescent Dye Improves Cell-Based Assays for Ion ChannelsJournal of Biomolecular Screening2002141
37Epigenetic Drug Discovery: Targeting DNA MethyltransferasesJournal of Biomolecular Screening2012138
38SIRT1 Modulating Compounds from High-Throughput Screening as Anti-Inflammatory and Insulin-Sensitizing AgentsJournal of Biomolecular Screening2006137
39Application of a High-Content Multiparameter Cytotoxicity Assay to Prioritize Compounds Based on Toxicity Potential in HumansJournal of Biomolecular Screening2008137
40A Fluorescent Ligand-Binding Alternative Using Tag-lite® TechnologyJournal of Biomolecular Screening2010135
41Population Patch Clamp Improves Data Consistency and Success Rates in the Measurement of Ionic CurrentsJournal of Biomolecular Screening2006133
42Are GPCRs Still a Source of New Targets?Journal of Biomolecular Screening2013133
43DMSO-Related Effects in Protein CharacterizationJournal of Biomolecular Screening2006131
44Multiparameter In Vitro Assessment of Compound Effects on Cardiomyocyte Physiology Using iPSC CellsJournal of Biomolecular Screening2013130
45A Comparison of ALPHAScreen, TR-FRET, and TRF as Assay Methods for FXR Nuclear ReceptorsJournal of Biomolecular Screening2002128
46A High-Throughput Cell-Based Assay for Inhibitors of ABCG2 ActivityJournal of Biomolecular Screening2006128
47Sirtuin 1 (SIRT1): The Misunderstood HDACJournal of Biomolecular Screening2011128
48Modulation of NF-κB Signaling as a Therapeutic Target in AutoimmunityJournal of Biomolecular Screening2016122
49HTRF® TechnologyJournal of Biomolecular Screening1999121
50Optimization of a Higher Throughput Microsomal Stability Screening Assay for Profiling Drug Discovery CandidatesJournal of Biomolecular Screening2003120