# | Title | Journal | Year | Citations |
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1 | The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs | Aging Cell | 2015 | 1,534 |
2 | Senescence-associated β-galactosidase is lysosomal β-galactosidase | Aging Cell | 2006 | 991 |
3 | Fat tissue, aging, and cellular senescence | Aging Cell | 2010 | 834 |
4 | Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans | Aging Cell | 2007 | 784 |
5 | Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR-γ2 transcription factor and TGF-β/BMP signaling pathways | Aging Cell | 2004 | 718 |
6 | Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors | Aging Cell | 2016 | 717 |
7 | Age‐related intrinsic changes in human bone‐marrow‐derived mesenchymal stem cells and their differentiation to osteoblasts | Aging Cell | 2008 | 668 |
8 | DNA methylation and healthy human aging | Aging Cell | 2015 | 665 |
9 | SIRT1 transgenic mice show phenotypes resembling calorie restriction | Aging Cell | 2007 | 656 |
10 | Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance | Aging Cell | 2005 | 644 |
11 | Calcium and neurodegeneration | Aging Cell | 2007 | 643 |
12 | SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction | Aging Cell | 2007 | 587 |
13 | Rapamycin slows aging in mice | Aging Cell | 2012 | 580 |
14 | DNA damage response and cellular senescence in tissues of aging mice | Aging Cell | 2009 | 566 |
15 | How sex and age affect immune responses, susceptibility to infections, and response to vaccination | Aging Cell | 2015 | 552 |
16 | Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice | Aging Cell | 2016 | 540 |
17 | A senescent cell bystander effect: senescence‐induced senescence | Aging Cell | 2012 | 538 |
18 | Long live FOXO: unraveling the role of FOXO proteins in aging and longevity | Aging Cell | 2016 | 537 |
19 | Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans | Aging Cell | 2009 | 518 |
20 | Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer | Aging Cell | 2004 | 505 |
21 | Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction | Aging Cell | 2014 | 486 |
22 | Interventions to Slow Aging in Humans: Are We Ready? | Aging Cell | 2015 | 481 |
23 | p16INK4Ais a robust in vivo biomarker of cellular aging in human skin | Aging Cell | 2006 | 474 |
24 | Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study | Aging Cell | 2006 | 465 |
25 | Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans | Aging Cell | 2007 | 464 |
26 | Oxidative stress and aberrant signaling in aging and cognitive decline | Aging Cell | 2007 | 449 |
27 | Accelerated epigenetic aging in Down syndrome | Aging Cell | 2015 | 446 |
28 | Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan | Aging Cell | 2007 | 442 |
29 | The chronological life span of Saccharomyces cerevisiae | Aging Cell | 2003 | 437 |
30 | Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening | Aging Cell | 2010 | 434 |
31 | Postmitotic neurons develop a p21‐dependent senescence‐like phenotype driven by a DNA damage response | Aging Cell | 2012 | 434 |
32 | Metformin inhibits the senescence‐associated secretory phenotype by interfering with IKK/NF‐κB activation | Aging Cell | 2013 | 422 |
33 | Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function | Aging Cell | 2012 | 407 |
34 | Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease | Aging Cell | 2019 | 403 |
35 | Targeting senescent cells alleviates obesity‐induced metabolic dysfunction | Aging Cell | 2019 | 395 |
36 | Dietary composition specifies consumption, obesity, and lifespan in Drosophila melanogaster | Aging Cell | 2008 | 391 |
37 | B‐cell diversity decreases in old age and is correlated with poor health status | Aging Cell | 2009 | 386 |
38 | Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16 | Aging Cell | 2003 | 383 |
39 | Expression of p16INK4a in peripheral blood T‐cells is a biomarker of human aging | Aging Cell | 2009 | 381 |
40 | Innate immunity in aging: impact on macrophage function | Aging Cell | 2004 | 380 |
41 | DNA methylation pattern changes upon long‐term culture and aging of human mesenchymal stromal cells | Aging Cell | 2010 | 378 |
42 | Tau protein aggregation is associated with cellular senescence in the brain | Aging Cell | 2018 | 376 |
43 | Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans | Aging Cell | 2006 | 375 |
44 | Calorie restriction mimetics: an emerging research field | Aging Cell | 2006 | 372 |
45 | Age‐related alterations in the dynamic behavior of microglia | Aging Cell | 2011 | 372 |
46 | Neurogenesis and aging: FGF-2 and HB-EGF restore neurogenesis in hippocampus and subventricular zone of aged mice | Aging Cell | 2003 | 364 |
47 | Measuring biological aging in humans: A quest | Aging Cell | 2020 | 364 |
48 | Methylation of ELOVL2 gene as a new epigenetic marker of age | Aging Cell | 2012 | 362 |
49 | Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels | Aging Cell | 2009 | 359 |
50 | Mitochondrial function and apoptotic susceptibility in aging skeletal muscle | Aging Cell | 2008 | 357 |