| # | Title | Journal | Year | Citations |
|---|
| 1 | Acidic extracellular microenvironment and cancer | Cancer Cell International | 2013 | 1,009 |
| 2 | MicroRNA (miRNA) in cancer | Cancer Cell International | 2015 | 478 |
| 3 | Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp | Cancer Cell International | 2015 | 451 |
| 4 | ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal | Cancer Cell International | 2005 | 393 |
| 5 | Survivin: a unique target for tumor therapy | Cancer Cell International | 2016 | 328 |
| 6 | Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunity | Cancer Cell International | 2015 | 299 |
| 7 | The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment | Cancer Cell International | 2021 | 296 |
| 8 | Microsatellite instability: a review of what the oncologist should know | Cancer Cell International | 2020 | 269 |
| 9 | Patient-derived xenografts of different grade gliomas retain the heterogeneous histological and genetic features of human gliomas | Cancer Cell International | 2020 | 260 |
| 10 | Clinical implications and utility of field cancerization | Cancer Cell International | 2007 | 230 |
| 11 | Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties | Cancer Cell International | 2013 | 225 |
| 12 | Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy | Cancer Cell International | 2005 | 196 |
| 13 | New insights into M1/M2 macrophages: key modulators in cancer progression | Cancer Cell International | 2021 | 193 |
| 14 | Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight | Cancer Cell International | 2018 | 192 |
| 15 | Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells | Cancer Cell International | 2006 | 185 |
| 16 | The effect of 2D and 3D cell cultures on treatment response, EMT profile and stem cell features in head and neck cancer | Cancer Cell International | 2019 | 170 |
| 17 | Challenges of applying multicellular tumor spheroids in preclinical phase | Cancer Cell International | 2021 | 168 |
| 18 | Release of volatile organic compounds (VOCs) from the lung cancer cell line CALU-1 in vitro | Cancer Cell International | 2008 | 163 |
| 19 | Ninjurin 2 rs118050317 gene polymorphism and endometrial cancer risk | Cancer Cell International | 2021 | 158 |
| 20 | p53 signaling in cancer progression and therapy | Cancer Cell International | 2021 | 153 |
| 21 | Prostate specific membrane antigen (PSMA) expression in primary gliomas and breast cancer brain metastases | Cancer Cell International | 2014 | 152 |
| 22 | The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance | Cancer Cell International | 2014 | 152 |
| 23 | MiR-214 regulate gastric cancer cell proliferation, migration and invasion by targeting PTEN | Cancer Cell International | 2013 | 149 |
| 24 | A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesis | Cancer Cell International | 2003 | 148 |
| 25 | Wnt signal transduction pathway and apoptosis: a review | Cancer Cell International | 2010 | 143 |
| 26 | Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment | Cancer Cell International | 2021 | 139 |
| 27 | circRNA-miRNA-mRNA regulatory network in human lung cancer: an update | Cancer Cell International | 2020 | 136 |
| 28 | Identification of a six-gene signature predicting overall survival for hepatocellular carcinoma | Cancer Cell International | 2019 | 135 |
| 29 | The role of CDC25C in cell cycle regulation and clinical cancer therapy: a systematic review | Cancer Cell International | 2020 | 135 |
| 30 | Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine | Cancer Cell International | 2022 | 135 |
| 31 | The role of MDM2 amplification and overexpression in therapeutic resistance of malignant tumors | Cancer Cell International | 2019 | 133 |
| 32 | Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal | Cancer Cell International | 2013 | 131 |
| 33 | Up regulation of Bax and down regulation of Bcl2 during 3-NC mediated apoptosis in human cancer cells | Cancer Cell International | 2015 | 131 |
| 34 | Novel sulphamoylated 2-methoxy estradiol derivatives inhibit breast cancer migration by disrupting microtubule turnover and organization | Cancer Cell International | 2019 | 130 |
| 35 | Deregulation of histone lysine methyltransferases contributes to oncogenic transformation of human bronchoepithelial cells | Cancer Cell International | 2008 | 129 |
| 36 | The diverse mechanisms and anticancer potential of naphthoquinones | Cancer Cell International | 2019 | 126 |
| 37 | The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression | Cancer Cell International | 2006 | 124 |
| 38 | Induction of G1-phase cell cycle arrest and apoptosis pathway in MDA-MB-231 human breast cancer cells by sulfated polysaccharide extracted from Laurencia papillosa | Cancer Cell International | 2016 | 124 |
| 39 | B7-H3 promotes aggression and invasion of hepatocellular carcinoma by targeting epithelial-to-mesenchymal transition via JAK2/STAT3/Slug signaling pathway | Cancer Cell International | 2015 | 120 |
| 40 | The anticancer effects of ferulic acid is associated with induction of cell cycle arrest and autophagy in cervical cancer cells | Cancer Cell International | 2018 | 118 |
| 41 | ALKBH5-mediated m6A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma | Cancer Cell International | 2020 | 117 |
| 42 | Clinical applications of artificial intelligence and machine learning in cancer diagnosis: looking into the future | Cancer Cell International | 2021 | 117 |
| 43 | Evaluating the evidence for targeting FOXO3a in breast cancer: a systematic review | Cancer Cell International | 2015 | 116 |
| 44 | Tumor mutation burden: from comprehensive mutational screening to the clinic | Cancer Cell International | 2019 | 116 |
| 45 | Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio | Cancer Cell International | 2007 | 114 |
| 46 | Effect of lycopene on cell viability and cell cycle progression in human cancer cell lines | Cancer Cell International | 2012 | 113 |
| 47 | The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells | Cancer Cell International | 2019 | 113 |
| 48 | Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines | Cancer Cell International | 2006 | 111 |
| 49 | Role of stem cells in cancer therapy and cancer stem cells: a review | Cancer Cell International | 2007 | 110 |
| 50 | The chemotherapeutic agent bortezomib induces the formation of stress granules | Cancer Cell International | 2010 | 109 |
