# | Title | Journal | Year | Citations |
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1 | Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals | Biopharmaceutics and Drug Disposition | 1995 | 1,236 |
2 | Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery | Biopharmaceutics and Drug Disposition | 2002 | 382 |
3 | Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption | Biopharmaceutics and Drug Disposition | 2013 | 345 |
4 | SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria | Biopharmaceutics and Drug Disposition | 2014 | 288 |
5 | Drugs and the liver part 1: Testing liver function | Biopharmaceutics and Drug Disposition | 1991 | 254 |
6 | Chiral separation by chromatographic and electromigration techniques. A Review | Biopharmaceutics and Drug Disposition | 2001 | 217 |
7 | Quercetin pharmacokinetics in humans | Biopharmaceutics and Drug Disposition | 2008 | 207 |
8 | Pharmacological effects and pharmacokinetics properties ofRadix Scutellariaeand its bioactive flavones | Biopharmaceutics and Drug Disposition | 2011 | 207 |
9 | Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology | Biopharmaceutics and Drug Disposition | 2010 | 205 |
10 | The potential role of lysosomes in tissue distribution of weak bases | Biopharmaceutics and Drug Disposition | 1988 | 190 |
11 | Pharmacokinetics and tissue distribution of olanzapine in rats | Biopharmaceutics and Drug Disposition | 1999 | 175 |
12 | Plasma concentration profiles of ketamine and norketamine after administration of various ketamine preparations to healthy Japanese volunteers | Biopharmaceutics and Drug Disposition | 2003 | 168 |
13 | Acyl glucuronides: the good, the bad and the ugly | Biopharmaceutics and Drug Disposition | 2010 | 156 |
14 | Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters | Biopharmaceutics and Drug Disposition | 2009 | 155 |
15 | Microbially controlled drug delivery to the colon | Biopharmaceutics and Drug Disposition | 1990 | 149 |
16 | Disposition kinetics ofSaccharomyces boulardii in man and rat | Biopharmaceutics and Drug Disposition | 1989 | 142 |
17 | Dose-linear pharmacokinetics of oleanolic acid after intravenous and oral administration in rats | Biopharmaceutics and Drug Disposition | 2007 | 138 |
18 | Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats | Biopharmaceutics and Drug Disposition | 2009 | 138 |
19 | Human radiolabeled mass balance studies: objectives, utilities and limitations | Biopharmaceutics and Drug Disposition | 2009 | 132 |
20 | Kinetics of cocaine in humans after intravenous and intranasal administration | Biopharmaceutics and Drug Disposition | 1983 | 129 |
21 | Drug disposition in three dimensions: an update on stereoselectivity in pharmacokinetics | Biopharmaceutics and Drug Disposition | 2006 | 128 |
22 | A novel pH sensitive N‐succinyl chitosan/alginate hydrogel bead for nifedipine delivery | Biopharmaceutics and Drug Disposition | 2008 | 128 |
23 | Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21) | Biopharmaceutics and Drug Disposition | 2013 | 122 |
24 | Linezolid absolute bioavailability and the effect of food on oral bioavailability | Biopharmaceutics and Drug Disposition | 2001 | 118 |
25 | Does age affect gastric emptying time? A model‐based meta‐analysis of data from premature neonates through to adults | Biopharmaceutics and Drug Disposition | 2015 | 116 |
26 | Diverse approaches for the enhancement of oral drug bioavailability | Biopharmaceutics and Drug Disposition | 2011 | 114 |
27 | Novel assay and pharmacokinetics of levamisole andp-hydroxylevamisole in human plasma and urine | Biopharmaceutics and Drug Disposition | 1986 | 111 |
28 | The bioavailability and pharmacokinetics of glucosamine hydrochloride and low molecular weight chondroitin sulfate after single and multiple doses to beagle dogs | Biopharmaceutics and Drug Disposition | 2002 | 110 |
29 | Effect of dose and food on the bioavailability of cefuroxime axetil | Biopharmaceutics and Drug Disposition | 1987 | 108 |
30 | Presystemic metabolism and intestinal absorption of antipsoriatic fumaric acid esters | Biopharmaceutics and Drug Disposition | 2003 | 108 |
31 | Albumin is the main plasma binding protein for indoxyl sulfate and p‐cresyl sulfate | Biopharmaceutics and Drug Disposition | 2013 | 104 |
32 | Adriamycin-loaded albumin microspheres: Preparation,in vivo distribution and release in the rat | Biopharmaceutics and Drug Disposition | 1985 | 102 |
33 | Pharmacokinetics and metabolism of codeine in humans | Biopharmaceutics and Drug Disposition | 1992 | 101 |
34 | Induction of NRF2‐mediated gene expression by dietary phytochemical flavones apigenin and luteolin | Biopharmaceutics and Drug Disposition | 2015 | 100 |
35 | Activation of beclomethasone dipropionate by hydrolysis to beclomethasone-17-monopropionate | Biopharmaceutics and Drug Disposition | 1990 | 99 |
36 | Pharmacokinetics of selected chiral flavonoids: hesperetin, naringenin and eriodictyol in rats and their content in fruit juices | Biopharmaceutics and Drug Disposition | 2008 | 97 |
37 | Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies | Biopharmaceutics and Drug Disposition | 2012 | 96 |
38 | Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanistic in vitro–in vivo extrapolation of oral drug absorption | Biopharmaceutics and Drug Disposition | 2013 | 96 |
39 | Pharmacokinetics of a ginseng saponin metabolite compound K in rats | Biopharmaceutics and Drug Disposition | 2006 | 95 |
40 | Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates | Biopharmaceutics and Drug Disposition | 2011 | 95 |
41 | Mechanistic investigation of food effect on disintegration and dissolution of BCS class III compound solid formulations: the importance of viscosity | Biopharmaceutics and Drug Disposition | 2012 | 95 |
42 | Pharmacokinetics of repeated single oral doses of enalapril maleate (mk-421) in normal volunteers | Biopharmaceutics and Drug Disposition | 1984 | 93 |
43 | Bioavailability of melatonin in humans after day-time administration of D7 melatonin | Biopharmaceutics and Drug Disposition | 2000 | 92 |
44 | Comparative binding affinities of tamoxifen, 4-hydroxytamoxifen, and desmethyltamoxifen for estrogen receptors isolated from human breast carcinoma: Correlation with blood levels in patients with metastatic breast cancer | Biopharmaceutics and Drug Disposition | 1981 | 89 |
45 | The outstanding metabolic stability of a14C-labeled?-nonapeptide in rats -in vitro andin vivo pharmacokinetic studies | Biopharmaceutics and Drug Disposition | 2002 | 88 |
46 | Intestinal lymphatic absorption of cyclosporin a following oral administration in an olive oil solution in rats | Biopharmaceutics and Drug Disposition | 1983 | 86 |
47 | Relationship between lung tissue and blood plasma concentrations of inhaled budesonide | Biopharmaceutics and Drug Disposition | 1993 | 85 |
48 | The bioavailability and pharmacokinetics of glucosamine hydrochloride and chondroitin sulfate after oral and intravenous single dose administration in the horse | Biopharmaceutics and Drug Disposition | 2004 | 85 |
49 | Prediction of human clearance of therapeutic proteins: simple allometric scaling method revisited | Biopharmaceutics and Drug Disposition | 2010 | 85 |
50 | In silico prediction of drug dissolution and absorption with variation in intestinal pH for BCS class II weak acid drugs: ibuprofen and ketoprofen | Biopharmaceutics and Drug Disposition | 2012 | 85 |