| # | Title | Journal | Year | Citations |
|---|
| 1 | Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy | Nature Reviews Neurology | 2013 | 2,482 |
| 2 | Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders | Nature Reviews Neurology | 2018 | 1,731 |
| 3 | Cerebrospinal fluid and plasma biomarkers in Alzheimer disease | Nature Reviews Neurology | 2010 | 1,598 |
| 4 | Ageing as a risk factor for neurodegenerative disease | Nature Reviews Neurology | 2019 | 1,578 |
| 5 | The clinical use of structural MRI in Alzheimer disease | Nature Reviews Neurology | 2010 | 1,505 |
| 6 | The role of inflammation in epilepsy | Nature Reviews Neurology | 2011 | 1,442 |
| 7 | Microglia in neurodegenerative disease | Nature Reviews Neurology | 2010 | 1,354 |
| 8 | Epidemiology of Alzheimer disease | Nature Reviews Neurology | 2011 | 1,299 |
| 9 | Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? | Nature Reviews Neurology | 2021 | 1,242 |
| 10 | Neurofilaments as biomarkers in neurological disorders | Nature Reviews Neurology | 2018 | 1,177 |
| 11 | Clearance systems in the brain—implications for Alzheimer disease | Nature Reviews Neurology | 2015 | 1,127 |
| 12 | Microglial and macrophage polarization—new prospects for brain repair | Nature Reviews Neurology | 2015 | 1,093 |
| 13 | Changing patterns in the epidemiology of traumatic brain injury | Nature Reviews Neurology | 2013 | 1,036 |
| 14 | 100 years of Lewy pathology | Nature Reviews Neurology | 2013 | 939 |
| 15 | Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums | Nature Reviews Neurology | 2018 | 905 |
| 16 | The retina as a window to the brain—from eye research to CNS disorders | Nature Reviews Neurology | 2013 | 881 |
| 17 | Huntington disease: natural history, biomarkers and prospects for therapeutics | Nature Reviews Neurology | 2014 | 873 |
| 18 | Depression and risk of developing dementia | Nature Reviews Neurology | 2011 | 834 |
| 19 | Microglial priming in neurodegenerative disease | Nature Reviews Neurology | 2014 | 827 |
| 20 | White matter hyperintensities, cognitive impairment and dementia: an update | Nature Reviews Neurology | 2015 | 811 |
| 21 | Brain-derived neurotrophic factor in neurodegenerative diseases | Nature Reviews Neurology | 2009 | 803 |
| 22 | Disease and the brain's dark energy | Nature Reviews Neurology | 2010 | 803 |
| 23 | Progressive multiple sclerosis: pathology and pathogenesis | Nature Reviews Neurology | 2012 | 793 |
| 24 | Delirium in elderly adults: diagnosis, prevention and treatment | Nature Reviews Neurology | 2009 | 772 |
| 25 | Guillain–Barré syndrome: pathogenesis, diagnosis, treatment and prognosis | Nature Reviews Neurology | 2014 | 752 |
| 26 | Tau-targeting therapies for Alzheimer disease | Nature Reviews Neurology | 2018 | 748 |
| 27 | Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies | Nature Reviews Neurology | 2019 | 734 |
| 28 | Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis | Nature Reviews Neurology | 2017 | 730 |
| 29 | Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury | Nature Reviews Neurology | 2010 | 723 |
| 30 | Deep brain stimulation: current challenges and future directions | Nature Reviews Neurology | 2019 | 721 |
| 31 | Cognitive decline in Parkinson disease | Nature Reviews Neurology | 2017 | 705 |
| 32 | The secretases: enzymes with therapeutic potential in Alzheimer disease | Nature Reviews Neurology | 2010 | 702 |
| 33 | HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment | Nature Reviews Neurology | 2016 | 690 |
| 34 | Maternal immune activation and abnormal brain development across CNS disorders | Nature Reviews Neurology | 2014 | 687 |
| 35 | The far-reaching scope of neuroinflammation after traumatic brain injury | Nature Reviews Neurology | 2017 | 687 |
| 36 | Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease | Nature Reviews Neurology | 2018 | 687 |
| 37 | Sleep and Alzheimer disease pathology—a bidirectional relationship | Nature Reviews Neurology | 2014 | 684 |
| 38 | The role of inflammation in perinatal brain injury | Nature Reviews Neurology | 2015 | 669 |
| 39 | A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease | Nature Reviews Neurology | 2019 | 666 |
| 40 | Clinical genetics of amyotrophic lateral sclerosis: what do we really know? | Nature Reviews Neurology | 2011 | 661 |
| 41 | The epidemiology of ALS: a conspiracy of genes, environment and time | Nature Reviews Neurology | 2013 | 658 |
| 42 | Delayed neurological deterioration after subarachnoid haemorrhage | Nature Reviews Neurology | 2014 | 657 |
| 43 | ER stress and the unfolded protein response in neurodegeneration | Nature Reviews Neurology | 2017 | 656 |
| 44 | MGMT promoter methylation in malignant gliomas: ready for personalized medicine? | Nature Reviews Neurology | 2010 | 644 |
| 45 | Modulation of brain plasticity in stroke: a novel model for neurorehabilitation | Nature Reviews Neurology | 2014 | 644 |
| 46 | CGRP as the target of new migraine therapies — successful translation from bench to clinic | Nature Reviews Neurology | 2018 | 617 |
| 47 | Disorders of consciousness after acquired brain injury: the state of the science | Nature Reviews Neurology | 2014 | 610 |
| 48 | Tau and neurodegenerative disease: the story so far | Nature Reviews Neurology | 2016 | 603 |
| 49 | Chronic neuropathologies of single and repetitive TBI: substrates of dementia? | Nature Reviews Neurology | 2013 | 590 |
| 50 | Classifying neurocognitive disorders: the DSM-5 approach | Nature Reviews Neurology | 2014 | 589 |
