Metabolic Brain Disease

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#	Title	Journal	Year	Citations
1	The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression	Metabolic Brain Disease	2009	775
2	Pathophysiology of hepatic encephalopathy: a new look at ammonia	Metabolic Brain Disease	2002	282
3	Maternal Separation in Rats Leads to Anxiety-Like Behavior and a Blunted ACTH Response and Altered Neurotransmitter Levels in Response to a Subsequent Stressor	Metabolic Brain Disease	2004	274
4	Pathophysiology of Stroke: Lessons from Animal Models	Metabolic Brain Disease	2004	270
5	Characteristics of Minimal Hepatic Encephalopathy	Metabolic Brain Disease	2004	251
6	Microglia	Metabolic Brain Disease	2004	220
7	Role of ammonia and inflammation in minimal hepatic encephalopathy	Metabolic Brain Disease	2007	219
8	GABA receptors in brain development, function, and injury	Metabolic Brain Disease	2015	215
9	Fetal alcohol syndrome: the vulnerability of the developing brain and possible mechanisms of damage	Metabolic Brain Disease	1994	210
10	Muscle depletion increases the risk of overt and minimal hepatic encephalopathy: results of a prospective study	Metabolic Brain Disease	2013	201
11	Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia	Metabolic Brain Disease	2015	199
12	Identifying the direct effects of ammonia on the brain	Metabolic Brain Disease	2009	193
13	Hypoglycemic Brain Damage	Metabolic Brain Disease	2004	186
14	Manganese toxicity, dopaminergic dysfunction and hepatic encephalopathy	Metabolic Brain Disease	1995	179
15	Valproate-induced hyperammonemic encephalopathy	Metabolic Brain Disease	2002	167
16	Exercise increases BDNF levels in the striatum and decreases depressive-like behavior in chronically stressed rats	Metabolic Brain Disease	2009	167
17	Ammonia toxicity: from head to toe?	Metabolic Brain Disease	2017	166
18	Protection against hippocampal CA1 cell loss by post-ischemie hypothermia is dependent on delay of initiation and duration	Metabolic Brain Disease	1992	164
19	Mechanisms of Ammonia-Induced Astrocyte Swelling	Metabolic Brain Disease	2005	164
20	New concepts in the mechanism of ammonia-induced astrocyte swelling	Metabolic Brain Disease	2007	161
21	Astroglial dysfunction in hepatic encephalopathy	Metabolic Brain Disease	1998	154
22	Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease	Metabolic Brain Disease	1990	153
23	Attention, Memory, and Cognitive Function in Hepatic Encephalopathy	Metabolic Brain Disease	2005	149
24	Contribution of hyperammonemia and inflammatory factors to cognitive impairment in minimal hepatic encephalopathy	Metabolic Brain Disease	2012	148
25	IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke	Metabolic Brain Disease	2013	129
26	Cognitive dysfunction induced by chronic administration of common cancer chemotherapeutics in rats	Metabolic Brain Disease	2008	127
27	Morphine metabolism, transport and brain disposition	Metabolic Brain Disease	2012	126
28	Diet, gut microbiota and cognition	Metabolic Brain Disease	2017	126
29	Post-occlusion treatment with BDNF reduces infarct size in a model of permanent occlusion of the middle cerebral artery in rat	Metabolic Brain Disease	1997	125
30	Oxidative Stress in the Pathogenesis of Hepatic Encephalopathy	Metabolic Brain Disease	2004	124
31	Manganese neurotoxicity: an update of pathophysiologic mechanisms	Metabolic Brain Disease	2002	123
32	Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy	Metabolic Brain Disease	2009	120
33	Taurine as osmoregulator and neuromodulator in the brain	Metabolic Brain Disease	1996	119
34	Signaling factors in the mechanism of ammonia neurotoxicity	Metabolic Brain Disease	2009	119
35	Neuropsychological aspects of portal-systemic encephalopathy	Metabolic Brain Disease	1998	118
36	Synergistic tonic and phasic activity of the locus coeruleus norepinephrine (LC-NE) arousal system is required for optimal attentional performance	Metabolic Brain Disease	2012	118
37	Pathophysiology and Clinical Features of Wilson Disease	Metabolic Brain Disease	2004	117
38	Pallidal lesions in patients with liver cirrhosis: clinical and MRI evaluation	Metabolic Brain Disease	1995	116
39	The role of the microglia in acute CNS injury	Metabolic Brain Disease	2015	116
40	Blood–brain barrier dysfunction following traumatic brain injury	Metabolic Brain Disease	2015	115
41	Brain cytokine flux in acute liver failure and its relationship with intracranial hypertension	Metabolic Brain Disease	2007	113
42	Neuronal cell death in hepatic encephalopathy	Metabolic Brain Disease	2007	112
43	The Na–K–Cl Co-transporter in astrocyte swelling	Metabolic Brain Disease	2010	112
44	Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: Interference of AMPK/PGC-1α pathway	Metabolic Brain Disease	2014	112
45	Pathophysiology of alcoholic brain damage: synergistic effects of ethanol, thiamine deficiency and alcoholic liver disease	Metabolic Brain Disease	1995	111
46	Mechanisms of neuronal cell death in Wernicke's encephalopathy	Metabolic Brain Disease	1998	111
47	Blood Ammonia Levels and Hepatic Encephalopathy	Metabolic Brain Disease	2004	110
48	Mitochondrial dysfunctions in Myalgic Encephalomyelitis / chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways	Metabolic Brain Disease	2014	109
49	Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins	Metabolic Brain Disease	2009	108
50	An international perspective on the prevalence of the Wernicke-Korsakoff syndrome	Metabolic Brain Disease	1995	107

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