| # | Title | Journal | Year | Citations |
|---|
| 1 | Role of proinflammatory cytokines in the pathophysiology of osteoarthritis | Nature Reviews Rheumatology | 2011 | 1,973 |
| 2 | Fracture healing: mechanisms and interventions | Nature Reviews Rheumatology | 2015 | 1,159 |
| 3 | Role of cytokines in intervertebral disc degeneration: pain and disc content | Nature Reviews Rheumatology | 2014 | 1,134 |
| 4 | The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis | Nature Reviews Rheumatology | 2010 | 1,029 |
| 5 | Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology | Nature Reviews Rheumatology | 2020 | 952 |
| 6 | TNF biology, pathogenic mechanisms and emerging therapeutic strategies | Nature Reviews Rheumatology | 2016 | 934 |
| 7 | Repair and tissue engineering techniques for articular cartilage | Nature Reviews Rheumatology | 2015 | 923 |
| 8 | Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis | Nature Reviews Rheumatology | 2016 | 917 |
| 9 | New insights into the immunopathogenesis of systemic lupus erythematosus | Nature Reviews Rheumatology | 2016 | 909 |
| 10 | Fracture healing under healthy and inflammatory conditions | Nature Reviews Rheumatology | 2012 | 904 |
| 11 | Global epidemiology of gout: prevalence, incidence and risk factors | Nature Reviews Rheumatology | 2015 | 854 |
| 12 | The individual and socioeconomic impact of osteoarthritis | Nature Reviews Rheumatology | 2014 | 757 |
| 13 | Ageing and the pathogenesis of osteoarthritis | Nature Reviews Rheumatology | 2016 | 745 |
| 14 | Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors | Nature Reviews Rheumatology | 2013 | 715 |
| 15 | IL-1 pathways in inflammation and human diseases | Nature Reviews Rheumatology | 2010 | 689 |
| 16 | Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment | Nature Reviews Rheumatology | 2012 | 675 |
| 17 | Bone remodelling in osteoarthritis | Nature Reviews Rheumatology | 2012 | 667 |
| 18 | HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease | Nature Reviews Rheumatology | 2012 | 596 |
| 19 | Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage–bone crosstalk | Nature Reviews Rheumatology | 2016 | 581 |
| 20 | Emerging role of extracellular vesicles in inflammatory diseases | Nature Reviews Rheumatology | 2014 | 563 |
| 21 | Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors | Nature Reviews Rheumatology | 2020 | 562 |
| 22 | The role of defective clearance of apoptotic cells in systemic autoimmunity | Nature Reviews Rheumatology | 2010 | 533 |
| 23 | Osteoporosis: impact on health and economics | Nature Reviews Rheumatology | 2010 | 520 |
| 24 | The bone–cartilage unit in osteoarthritis | Nature Reviews Rheumatology | 2011 | 502 |
| 25 | Macrophage heterogeneity in the context of rheumatoid arthritis | Nature Reviews Rheumatology | 2016 | 493 |
| 26 | Pathogenesis of antiphospholipid syndrome: understanding the antibodies | Nature Reviews Rheumatology | 2011 | 482 |
| 27 | Emerging regulators of the inflammatory process in osteoarthritis | Nature Reviews Rheumatology | 2015 | 475 |
| 28 | Pain, catastrophizing, and depression in the rheumatic diseases | Nature Reviews Rheumatology | 2011 | 470 |
| 29 | Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases | Nature Reviews Rheumatology | 2016 | 468 |
| 30 | The role of metabolism in the pathogenesis of osteoarthritis | Nature Reviews Rheumatology | 2017 | 438 |
| 31 | Wnt and PPARγ signaling in osteoblastogenesis and adipogenesis | Nature Reviews Rheumatology | 2009 | 426 |
| 32 | Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis | Nature Reviews Rheumatology | 2019 | 421 |
| 33 | The emerging safety profile of JAK inhibitors in rheumatic disease | Nature Reviews Rheumatology | 2017 | 420 |
| 34 | Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis | Nature Reviews Rheumatology | 2012 | 418 |
| 35 | The multifactorial role of neutrophils in rheumatoid arthritis | Nature Reviews Rheumatology | 2014 | 414 |
| 36 | Assessment of mechanisms in localized and widespread musculoskeletal pain | Nature Reviews Rheumatology | 2010 | 413 |
| 37 | Metabolic syndrome meets osteoarthritis | Nature Reviews Rheumatology | 2012 | 411 |
| 38 | Surgical and tissue engineering strategies for articular cartilage and meniscus repair | Nature Reviews Rheumatology | 2019 | 410 |
| 39 | Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes | Nature Reviews Rheumatology | 2020 | 400 |
| 40 | The role of the cartilage matrix in osteoarthritis | Nature Reviews Rheumatology | 2011 | 397 |
| 41 | Osteoimmunology and the effects of the immune system on bone | Nature Reviews Rheumatology | 2009 | 395 |
| 42 | Cytokines in rheumatoid arthritis — shaping the immunological landscape | Nature Reviews Rheumatology | 2016 | 385 |
| 43 | The microbiome and rheumatoid arthritis | Nature Reviews Rheumatology | 2011 | 381 |
| 44 | Periodontitis in systemic rheumatic diseases | Nature Reviews Rheumatology | 2009 | 380 |
| 45 | Progress in intra-articular therapy | Nature Reviews Rheumatology | 2014 | 375 |
| 46 | Arthritogenic alphaviruses—an overview | Nature Reviews Rheumatology | 2012 | 374 |
| 47 | Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges | Nature Reviews Rheumatology | 2015 | 372 |
| 48 | The role of mitochondria in osteoarthritis | Nature Reviews Rheumatology | 2011 | 371 |
| 49 | Leptin in the interplay of inflammation, metabolism and immune system disorders | Nature Reviews Rheumatology | 2017 | 371 |
| 50 | Translating IL-6 biology into effective treatments | Nature Reviews Rheumatology | 2020 | 369 |
