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Top Articles

#TitleJournalYearCitations
1THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUMJournal of Clinical Investigation19558,446
2The basics of epithelial-mesenchymal transitionJournal of Clinical Investigation20098,252
3Obesity is associated with macrophage accumulation in adipose tissueJournal of Clinical Investigation20037,111
4Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIAJournal of Clinical Investigation19736,420
5Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistanceJournal of Clinical Investigation20034,978
6Macrophage plasticity and polarization: in vivo veritasJournal of Clinical Investigation20124,755
7Obesity is associated with macrophage accumulation in adipose tissueJournal of Clinical Investigation20034,710
8Role of AMP-activated protein kinase in mechanism of metformin actionJournal of Clinical Investigation20014,597
9Increased oxidative stress in obesity and its impact on metabolic syndromeJournal of Clinical Investigation20044,302
10Liver fibrosisJournal of Clinical Investigation20054,210
11Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapiesJournal of Clinical Investigation20114,137
12Clinical and immunological features of severe and moderate coronavirus disease 2019Journal of Clinical Investigation20203,820
13Obesity induces a phenotypic switch in adipose tissue macrophage polarizationJournal of Clinical Investigation20073,739
14SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverJournal of Clinical Investigation20023,528
15Inflammation and insulin resistanceJournal of Clinical Investigation20063,417
16A RELATION BETWEEN NON-ESTERIFIED FATTY ACIDS IN PLASMA AND THE METABOLISM OF GLUCOSEJournal of Clinical Investigation19563,403
17Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsiaJournal of Clinical Investigation20033,356
18NF-κB: a key role in inflammatory diseasesJournal of Clinical Investigation20013,329
19An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.Journal of Clinical Investigation19903,267
20Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistanceJournal of Clinical Investigation20033,195
21TLR4 links innate immunity and fatty acid–induced insulin resistanceJournal of Clinical Investigation20063,012
22C-reactive protein: a critical updateJournal of Clinical Investigation20032,941
23Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.Journal of Clinical Investigation19952,938
24Inflammation, stress, and diabetesJournal of Clinical Investigation20052,822
25Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.Journal of Clinical Investigation19982,743
26Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENTJournal of Clinical Investigation19732,739
27Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver diseaseJournal of Clinical Investigation20052,731
28IMMUNOASSAY OF ENDOGENOUS PLASMA INSULIN IN MANJournal of Clinical Investigation19602,716
29Obesity and insulin resistanceJournal of Clinical Investigation20002,600
30IFN-γ–related mRNA profile predicts clinical response to PD-1 blockadeJournal of Clinical Investigation20172,560
31Secretory products of macrophages.Journal of Clinical Investigation19872,470
32Role of oxidized low density lipoprotein in atherogenesis.Journal of Clinical Investigation19912,453
33Mechanisms of fatty acid-induced inhibition of glucose uptake.Journal of Clinical Investigation19942,370
34Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndromeJournal of Clinical Investigation20062,339
35Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.Journal of Clinical Investigation19942,209
36Cellular mechanisms of insulin resistanceJournal of Clinical Investigation20002,199
37MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesityJournal of Clinical Investigation20062,190
38Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.Journal of Clinical Investigation19962,179
39SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverJournal of Clinical Investigation20022,177
40Sympathetic neural mechanisms in obstructive sleep apnea.Journal of Clinical Investigation19952,086
41Wall stress and patterns of hypertrophy in the human left ventricle.Journal of Clinical Investigation19752,081
42Endoplasmic reticulum stress: cell life and death decisionsJournal of Clinical Investigation20052,004
43Safety and antitumor activity of recombinant soluble Apo2 ligandJournal of Clinical Investigation19991,976
44Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.Journal of Clinical Investigation19891,967
45Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy geneJournal of Clinical Investigation20031,957
46The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.Journal of Clinical Investigation19981,945
47Epithelial-mesenchymal transition and its implications for fibrosisJournal of Clinical Investigation20031,937
48Biomarkers for epithelial-mesenchymal transitionsJournal of Clinical Investigation20091,907
49THE NITROUS OXIDE METHOD FOR THE QUANTITATIVE DETERMINATION OF CEREBRAL BLOOD FLOW IN MAN: THEORY, PROCEDURE AND NORMAL VALUES 1Journal of Clinical Investigation19481,860
50Inflammatory links between obesity and metabolic diseaseJournal of Clinical Investigation20111,845