| # | Title | Journal | Year | Citations |
|---|
| 1 | EQ-SD: a measure of health status from the EuroQol Group | Annals of Medicine | 2001 | 4,187 |
| 2 | Phyto-oestrogens and Western Diseases | Annals of Medicine | 1997 | 1,174 |
| 3 | Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity | Annals of Medicine | 2011 | 1,098 |
| 4 | The RAND-36 measure of health-related quality of life | Annals of Medicine | 2001 | 1,051 |
| 5 | Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis | Annals of Medicine | 2017 | 969 |
| 6 | The 15D instrument of health-related quality of life: properties and applications | Annals of Medicine | 2001 | 946 |
| 7 | PI3K/AKT signaling pathway and cancer: an updated review | Annals of Medicine | 2014 | 887 |
| 8 | Mechanobiology and diseases of mechanotransduction | Annals of Medicine | 2003 | 726 |
| 9 | A review of rapid prototyping techniques for tissue engineering purposes | Annals of Medicine | 2008 | 659 |
| 10 | The prevalence of celiac disease in Europe: Results of a centralized, international mass screening project | Annals of Medicine | 2010 | 658 |
| 11 | The Health Utilities Index (HUI®) system for assessing health-related quality of life in clinical studies | Annals of Medicine | 2001 | 625 |
| 12 | Collagens and collagen-related diseases | Annals of Medicine | 2001 | 607 |
| 13 | Function of C-reactive protein | Annals of Medicine | 2000 | 603 |
| 14 | Matrix metalloproteinases: Contribution to pathogenesis, diagnosis and treatment of periodontal inflammation | Annals of Medicine | 2006 | 550 |
| 15 | Age‐related macular degeneration—emerging pathogenetic and therapeutic concepts | Annals of Medicine | 2006 | 546 |
| 16 | Is visceral obesity the cause of the metabolic syndrome? | Annals of Medicine | 2006 | 511 |
| 17 | Predictive value of plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction | Annals of Medicine | 2011 | 506 |
| 18 | Heat shock proteins as cellular lifeguards | Annals of Medicine | 1999 | 469 |
| 19 | Efflux pumps as antimicrobial resistance mechanisms | Annals of Medicine | 2007 | 425 |
| 20 | Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation inalpha2‐macroglobulinandtau: A population‐based autopsy study | Annals of Medicine | 2008 | 414 |
| 21 | Sirtuins: The ‘magnificent seven’, function, metabolism and longevity | Annals of Medicine | 2007 | 394 |
| 22 | Trendsin Molecular Medicine: Matrix metalloproteinases and their inhibitors in tumour growth and invasion | Annals of Medicine | 1999 | 390 |
| 23 | A comparison of the Assessment of Quality of Life (AQoL) with four other generic utility instruments | Annals of Medicine | 2001 | 388 |
| 24 | CD163: a regulated hemoglobin scavenger receptor with a role in the anti‐inflammatory response | Annals of Medicine | 2004 | 378 |
| 25 | New strategies for identifying gene-gene interactions in hypertension | Annals of Medicine | 2002 | 377 |
| 26 | New Finnish growth references for children and adolescents aged 0 to 20 years: Length/height-for-age, weight-for-length/height, and body mass index-for-age | Annals of Medicine | 2011 | 377 |
| 27 | Differences in Lipolysis between Human Subcutaneous and Omental Adipose Tissues | Annals of Medicine | 1995 | 372 |
| 28 | Prevention of Travellers Diarrhoea by Lactobacillus GG | Annals of Medicine | 1990 | 363 |
| 29 | Role of serotonin in memory impairment | Annals of Medicine | 2000 | 357 |
| 30 | Targeting the ERK signaling pathway in cancer therapy | Annals of Medicine | 2006 | 357 |
| 31 | Immunosuppressive and Anti-inflammatory Properties of Interleukin 10 | Annals of Medicine | 1995 | 355 |
| 32 | Fetal origins of cardiovascular disease | Annals of Medicine | 1999 | 347 |
| 33 | Polyamines: from Molecular Biology to Clinical Applications | Annals of Medicine | 1991 | 339 |
| 34 | The Caveolin genes: from cell biology to medicine | Annals of Medicine | 2004 | 335 |
| 35 | Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction | Annals of Medicine | 2008 | 330 |
| 36 | Natural history of celiac disease autoimmunity in a USA cohort followed since 1974 | Annals of Medicine | 2010 | 324 |
| 37 | Effect ofLactobacillusGG Yoghurt in Prevention of Antibiotic Associated Diarrhoea | Annals of Medicine | 1990 | 318 |
| 38 | Mitochondrial DNA and disease | Annals of Medicine | 2005 | 316 |
| 39 | Children born after autotransplantation of cryopreserved ovarian tissue. A review of 13 live births | Annals of Medicine | 2011 | 309 |
| 40 | Non-lipid-related effects of statins | Annals of Medicine | 2000 | 300 |
| 41 | The role of mitochondrial dysfunction in cardiovascular disease: a brief review | Annals of Medicine | 2018 | 299 |
| 42 | Introducing economic and quality of life measurements into clinical studies | Annals of Medicine | 2001 | 296 |
| 43 | Efficacy and safety of three new oral antiviral treatment (molnupiravir, fluvoxamine and Paxlovid) for COVID-19：a meta-analysis | Annals of Medicine | 2022 | 290 |
| 44 | Prevalence of Symptoms Suggestive of Gastroesophageal Reflux Disease in an Adult Population | Annals of Medicine | 1995 | 287 |
| 45 | Dietary Factors and Risk of Colon Cancer | Annals of Medicine | 1994 | 284 |
| 46 | Health consequences of visceral obesity | Annals of Medicine | 2001 | 277 |
| 47 | Mitochondrial involvement in psychiatric disorders | Annals of Medicine | 2008 | 265 |
| 48 | Cytokines, stress and depressive illness: brain‐immune interactions | Annals of Medicine | 2003 | 264 |
| 49 | The metabolic syndrome: Role of skeletal muscle metabolism | Annals of Medicine | 2006 | 261 |
| 50 | Pathophysiology and mechanism of long COVID: a comprehensive review | Annals of Medicine | 2022 | 258 |
