# | Title | Journal | Year | Citations |
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1 | Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms | ACS Chemical Neuroscience | 2020 | 1,698 |
2 | Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties | ACS Chemical Neuroscience | 2010 | 763 |
3 | Brain Tissue Responses to Neural Implants Impact Signal Sensitivity and Intervention Strategies | ACS Chemical Neuroscience | 2015 | 429 |
4 | A Simple Method for Quantifying Functional Selectivity and Agonist Bias | ACS Chemical Neuroscience | 2012 | 422 |
5 | Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes | ACS Chemical Neuroscience | 2010 | 381 |
6 | The Rodent Forced Swim Test Measures Stress-Coping Strategy, Not Depression-like Behavior | ACS Chemical Neuroscience | 2017 | 345 |
7 | Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age | ACS Chemical Neuroscience | 2020 | 340 |
8 | Amyloid β-Protein Aggregation Produces Highly Reproducible Kinetic Data and Occurs by a Two-Phase Process | ACS Chemical Neuroscience | 2010 | 339 |
9 | Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery | ACS Chemical Neuroscience | 2016 | 338 |
10 | Knowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug Discovery | ACS Chemical Neuroscience | 2012 | 333 |
11 | Nonpsychotropic Plant Cannabinoids, Cannabidivarin (CBDV) and Cannabidiol (CBD), Activate and Desensitize Transient Receptor Potential Vanilloid 1 (TRPV1) Channels in Vitro: Potential for the Treatment of Neuronal Hyperexcitability | ACS Chemical Neuroscience | 2014 | 301 |
12 | SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection | ACS Chemical Neuroscience | 2020 | 293 |
13 | A Dialogue between the Immune System and Brain, Spoken in the Language of Serotonin | ACS Chemical Neuroscience | 2013 | 260 |
14 | Dual Effect of Amino Modified Polystyrene Nanoparticles on Amyloid β Protein Fibrillation | ACS Chemical Neuroscience | 2010 | 252 |
15 | Curcumin Modulates α-Synuclein Aggregation and Toxicity | ACS Chemical Neuroscience | 2013 | 252 |
16 | Neuroprotective Effects of Lithium: Implications for the Treatment of Alzheimer’s Disease and Related Neurodegenerative Disorders | ACS Chemical Neuroscience | 2014 | 239 |
17 | Exploring Chemical Space for Drug Discovery Using the Chemical Universe Database | ACS Chemical Neuroscience | 2012 | 228 |
18 | What Contributes to Serotonin–Norepinephrine Reuptake Inhibitors’ Dual-Targeting Mechanism? The Key Role of Transmembrane Domain 6 in Human Serotonin and Norepinephrine Transporters Revealed by Molecular Dynamics Simulation | ACS Chemical Neuroscience | 2018 | 225 |
19 | Improved Orange and Red Ca2+ Indicators and Photophysical Considerations for Optogenetic Applications | ACS Chemical Neuroscience | 2013 | 218 |
20 | Phosphodiesterases as Therapeutic Targets for Alzheimer's Disease | ACS Chemical Neuroscience | 2012 | 216 |
21 | Olive-Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer’s Disease: In Vitro and in Vivo Studies | ACS Chemical Neuroscience | 2013 | 214 |
22 | Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues | ACS Chemical Neuroscience | 2016 | 214 |
23 | Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA | ACS Chemical Neuroscience | 2015 | 202 |
24 | Why Is Research on Amyloid-β Failing to Give New Drugs for Alzheimer’s Disease? | ACS Chemical Neuroscience | 2017 | 201 |
25 | Central Processing of the Chemical Senses: An Overview | ACS Chemical Neuroscience | 2011 | 193 |
26 | Classics in Chemical Neuroscience: Diazepam (Valium) | ACS Chemical Neuroscience | 2014 | 190 |
27 | Drug–Target Kinetics in Drug Discovery | ACS Chemical Neuroscience | 2018 | 189 |
28 | Prevalence of Chemosensory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis Reveals Significant Ethnic Differences | ACS Chemical Neuroscience | 2020 | 189 |
29 | Tanshinones Inhibit Amyloid Aggregation by Amyloid-β Peptide, Disaggregate Amyloid Fibrils, and Protect Cultured Cells | ACS Chemical Neuroscience | 2013 | 180 |
30 | Hydrogen Sulfide: A Neuromodulator and Neuroprotectant in the Central Nervous System | ACS Chemical Neuroscience | 2014 | 169 |
31 | The Chemical Nature of Mercury in Human Brain Following Poisoning or Environmental Exposure | ACS Chemical Neuroscience | 2010 | 168 |
32 | Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135 | ACS Chemical Neuroscience | 2015 | 167 |
33 | Pomegranate’s Neuroprotective Effects against Alzheimer’s Disease Are Mediated by Urolithins, Its Ellagitannin-Gut Microbial Derived Metabolites | ACS Chemical Neuroscience | 2016 | 167 |
34 | Hitchhiker’s Guide to Voltammetry: Acute and Chronic Electrodes for in Vivo Fast-Scan Cyclic Voltammetry | ACS Chemical Neuroscience | 2017 | 167 |
35 | In Vivo Imaging of Human Neuroinflammation | ACS Chemical Neuroscience | 2016 | 165 |
36 | Effects of Lithium on Inflammation | ACS Chemical Neuroscience | 2014 | 157 |
37 | Tuning Photochromic Ion Channel Blockers | ACS Chemical Neuroscience | 2011 | 155 |
38 | The “Specific” P-Glycoprotein Inhibitor Tariquidar Is Also a Substrate and an Inhibitor for Breast Cancer Resistance Protein (BCRP/ABCG2) | ACS Chemical Neuroscience | 2011 | 153 |
39 | Neuroprotective Properties and Mechanisms of Resveratrol in in Vitro and in Vivo Experimental Cerebral Stroke Models | ACS Chemical Neuroscience | 2013 | 152 |
40 | Flavonoids as Therapeutic Compounds Targeting Key Proteins Involved in Alzheimer’s Disease | ACS Chemical Neuroscience | 2014 | 151 |
41 | Chemosensory Properties of the Trigeminal System | ACS Chemical Neuroscience | 2011 | 149 |
42 | Nerve Agents: What They Are, How They Work, How to Counter Them | ACS Chemical Neuroscience | 2018 | 147 |
43 | Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death | ACS Chemical Neuroscience | 2019 | 143 |
44 | Hydrogels in Spinal Cord Injury Repair Strategies | ACS Chemical Neuroscience | 2011 | 142 |
45 | Superparamagnetic Iron Oxide Nanoparticles: Promises for Diagnosis and Treatment of Multiple Sclerosis | ACS Chemical Neuroscience | 2011 | 141 |
46 | Gut Microbiota, Nitric Oxide, and Microglia as Prerequisites for Neurodegenerative Disorders | ACS Chemical Neuroscience | 2017 | 141 |
47 | Persistent Brainstem Dysfunction in Long-COVID: A Hypothesis | ACS Chemical Neuroscience | 2021 | 141 |
48 | Raman Spectroscopy: An Emerging Tool in Neurodegenerative Disease Research and Diagnosis | ACS Chemical Neuroscience | 2018 | 140 |
49 | Glycogen Synthase Kinase 3 Inhibition Promotes Adult Hippocampal Neurogenesis in Vitro and in Vivo | ACS Chemical Neuroscience | 2012 | 139 |
50 | Only a Fraction of Quantal Content is Released During Exocytosis as Revealed by Electrochemical Cytometry of Secretory Vesicles | ACS Chemical Neuroscience | 2010 | 138 |