| # | Title | Journal | Year | Citations |
|---|
| 1 | Signaling to NF-κB by Toll-like receptors | Trends in Molecular Medicine | 2007 | 1,932 |
| 2 | MicroRNAs in cancer: biomarkers, functions and therapy | Trends in Molecular Medicine | 2014 | 1,732 |
| 3 | Nrf2–Keap1 defines a physiologically important stress response mechanism | Trends in Molecular Medicine | 2004 | 1,529 |
| 4 | DNA damage-induced cell death by apoptosis | Trends in Molecular Medicine | 2006 | 1,272 |
| 5 | The ‘cytokine profile’: a code for sepsis | Trends in Molecular Medicine | 2005 | 1,066 |
| 6 | Inflammatory networks during cellular senescence: causes and consequences | Trends in Molecular Medicine | 2010 | 1,052 |
| 7 | Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide | Trends in Molecular Medicine | 2001 | 1,044 |
| 8 | Mesenchymal stem cells: building blocks for molecular medicine in the 21st century | Trends in Molecular Medicine | 2001 | 1,020 |
| 9 | MITF: master regulator of melanocyte development and melanoma oncogene | Trends in Molecular Medicine | 2006 | 993 |
| 10 | RANKL–RANK signaling in osteoclastogenesis and bone disease | Trends in Molecular Medicine | 2006 | 970 |
| 11 | HIF-1 and tumor progression: pathophysiology and therapeutics | Trends in Molecular Medicine | 2002 | 915 |
| 12 | CD39 and CD73 in immunity and inflammation | Trends in Molecular Medicine | 2013 | 914 |
| 13 | Microbiota and neurodevelopmental windows: implications for brain disorders | Trends in Molecular Medicine | 2014 | 852 |
| 14 | Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology | Trends in Molecular Medicine | 2001 | 830 |
| 15 | Protein carbonylation in human diseases | Trends in Molecular Medicine | 2003 | 813 |
| 16 | Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease | Trends in Molecular Medicine | 2008 | 799 |
| 17 | Sialic acids in human health and disease | Trends in Molecular Medicine | 2008 | 797 |
| 18 | Tau phosphorylation: the therapeutic challenge for neurodegenerative disease | Trends in Molecular Medicine | 2009 | 778 |
| 19 | Carbapenem resistance in Enterobacteriaceae: here is the storm! | Trends in Molecular Medicine | 2012 | 777 |
| 20 | The infant microbiome development: mom matters | Trends in Molecular Medicine | 2015 | 756 |
| 21 | The tripartite synapse: roles for gliotransmission in health and disease | Trends in Molecular Medicine | 2007 | 717 |
| 22 | MicroRNA expression and function in cancer | Trends in Molecular Medicine | 2006 | 699 |
| 23 | Protein S-nitrosylation in health and disease: a current perspective | Trends in Molecular Medicine | 2009 | 670 |
| 24 | The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer | Trends in Molecular Medicine | 2008 | 632 |
| 25 | Antibiotic-Induced Changes in the Intestinal Microbiota and Disease | Trends in Molecular Medicine | 2016 | 630 |
| 26 | Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway | Trends in Molecular Medicine | 2015 | 628 |
| 27 | Hsp90 inhibitors as novel cancer chemotherapeutic agents | Trends in Molecular Medicine | 2002 | 618 |
| 28 | Natural regulatory T cells: mechanisms of suppression | Trends in Molecular Medicine | 2007 | 616 |
| 29 | Circulating tumour cells in cancer patients: challenges and perspectives | Trends in Molecular Medicine | 2010 | 616 |
| 30 | Chemokines and chemokine receptors: new insights into cancer-related inflammation | Trends in Molecular Medicine | 2010 | 603 |
| 31 | Quantification using real-time PCR technology: applications and limitations | Trends in Molecular Medicine | 2002 | 602 |
| 32 | Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health | Trends in Molecular Medicine | 2007 | 594 |
| 33 | MUC1: a multifaceted oncoprotein with a key role in cancer progression | Trends in Molecular Medicine | 2014 | 592 |
| 34 | The role of pyocyanin in Pseudomonas aeruginosa infection | Trends in Molecular Medicine | 2004 | 591 |
| 35 | Why have clinical trials in sepsis failed? | Trends in Molecular Medicine | 2014 | 588 |
| 36 | Cell-penetrating peptides: breaking through to the other side | Trends in Molecular Medicine | 2012 | 586 |
| 37 | The role of selectins in inflammation and disease | Trends in Molecular Medicine | 2003 | 581 |
| 38 | Cancer nanomedicine: from targeted delivery to combination therapy | Trends in Molecular Medicine | 2015 | 578 |
| 39 | Disease Modeling in Stem Cell-Derived 3D Organoid Systems | Trends in Molecular Medicine | 2017 | 575 |
| 40 | Endoplasmic reticulum stress, obesity and diabetes | Trends in Molecular Medicine | 2012 | 559 |
| 41 | Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy | Trends in Molecular Medicine | 2001 | 558 |
| 42 | Osteoclast-derived activity in the coupling of bone formation to resorption | Trends in Molecular Medicine | 2005 | 550 |
| 43 | Mesenchymal stem cell therapy: Two steps forward, one step back | Trends in Molecular Medicine | 2010 | 545 |
| 44 | Clinical application of pharmacogenetics | Trends in Molecular Medicine | 2001 | 544 |
| 45 | NF-κB as a therapeutic target in cancer | Trends in Molecular Medicine | 2002 | 544 |
| 46 | Estrogen synthesis and signaling pathways during aging: from periphery to brain | Trends in Molecular Medicine | 2013 | 542 |
| 47 | let-7 microRNAs in development, stem cells and cancer | Trends in Molecular Medicine | 2008 | 539 |
| 48 | Pleiotropic effects of statin therapy: molecular mechanisms and clinical results | Trends in Molecular Medicine | 2008 | 522 |
| 49 | The Dual Roles of NRF2 in Cancer | Trends in Molecular Medicine | 2016 | 508 |
| 50 | S-nitrosylation in health and disease | Trends in Molecular Medicine | 2003 | 503 |
