| # | Title | Journal | Year | Citations |
|---|
| 1 | Mechanism of Action of Paracetamol | American Journal of Therapeutics | 2005 | 471 |
| 2 | Opioid Therapy and Immunosuppression | American Journal of Therapeutics | 2004 | 365 |
| 3 | Cyclooxygenase-2???Specific Inhibitors and Cardiorenal Function: A Randomized, Controlled Trial of Celecoxib and Rofecoxib in Older Hypertensive Osteoarthritis Patients | American Journal of Therapeutics | 2001 | 321 |
| 4 | Methylene Blue | American Journal of Therapeutics | 2003 | 291 |
| 5 | Autoimmune Destruction of Pancreatic β Cells | American Journal of Therapeutics | 2005 | 267 |
| 6 | Meperidine: A Critical Review | American Journal of Therapeutics | 2002 | 222 |
| 7 | Gastrointestinal Complications of Prescription and Over-the-Counter Nonsteroidal Anti-inflammatory Drugs | American Journal of Therapeutics | 2000 | 179 |
| 8 | Long-Acting Opioids for Chronic Pain: Pharmacotherapeutic Opportunities to Enhance Compliance, Quality of Life, and Analgesia | American Journal of Therapeutics | 2001 | 174 |
| 9 | Pharmacokinetic-Pharmacodynamic Crisis in the Elderly | American Journal of Therapeutics | 2007 | 173 |
| 10 | Immunomodulation and Blood Transfusion | American Journal of Therapeutics | 2002 | 167 |
| 11 | Antimicrobial Resistant Streptococcus pneumoniae: Prevalence, Mechanisms, and Clinical Implications | American Journal of Therapeutics | 2017 | 165 |
| 12 | Renal Safety and Tolerability of Celecoxib, a Novel Cyclooxygenase-2 Inhibitor | American Journal of Therapeutics | 2000 | 164 |
| 13 | Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines | American Journal of Therapeutics | 2021 | 160 |
| 14 | Confounding by Indication in Epidemiologic Studies of Commonly Used Analgesics | American Journal of Therapeutics | 2002 | 151 |
| 15 | The Impact of Pain on Quality of Life and the Unmet Needs of Pain Management: Results From Pain Sufferers and Physicians Participating in an Internet Survey | American Journal of Therapeutics | 2008 | 150 |
| 16 | Antimicrobial Properties of Honey | American Journal of Therapeutics | 2014 | 150 |
| 17 | Renal and Related Cardiovascular Effects of Conventional and COX-2-Specific NSAIDs and Non-NSAID Analgesics | American Journal of Therapeutics | 2000 | 143 |
| 18 | Pharmacokinetics and Pharmacodynamics of Febuxostat, a New Non-purine Selective Inhibitor of Xanthine Oxidase in Subjects with Renal Impairment | American Journal of Therapeutics | 2005 | 140 |
| 19 | Advances in the Treatment of Type 2 Diabetes Mellitus | American Journal of Therapeutics | 2011 | 134 |
| 20 | Drug-Herb Interaction Among Commonly Used Conventional Medicines: A Compendium for Health Care Professionals | American Journal of Therapeutics | 2003 | 133 |
| 21 | In Vitro Interaction of the HIV Protease Inhibitor Ritonavir with Herbal Constituents: Changes in P-gp and CYP3A4 Activity | American Journal of Therapeutics | 2004 | 133 |
| 22 | QT Prolongation and Fatal Arrhythmias: A Review of Clinical Implications and Effects of Drugs | American Journal of Therapeutics | 2003 | 132 |
| 23 | Valdecoxib, a COX-2???Specific Inhibitor, Is an Efficacious, Opioid-Sparing Analgesic in Patients Undergoing Hip Arthroplasty | American Journal of Therapeutics | 2002 | 130 |
| 24 | Do Sleep Disorders Have an Impact on Blood Pressure? | American Journal of Therapeutics | 2008 | 126 |
| 25 | Comorbidity of Irritable Bowel Syndrome in Psychiatric Patients: A Review | American Journal of Therapeutics | 2003 | 123 |
| 26 | Assessing the Impact of Protocol Design Changes on Clinical Trial Performance | American Journal of Therapeutics | 2008 | 123 |
| 27 | Vitamin E and Cardiovascular Disease | American Journal of Therapeutics | 2010 | 120 |
| 28 | Primary Sclerosing Cholangitis Associated with Elevated ImmunoglobulinG4: Clinical Characteristics and Response to Therapy | American Journal of Therapeutics | 2011 | 119 |
| 29 | The Therapeutic Use of Acetaminophen in Patients with Liver Disease | American Journal of Therapeutics | 2005 | 113 |
| 30 | Oat-derived β-Glucan Significantly Improves HDLC and Diminishes LDLC and Non-HDL Cholesterol in Overweight Individuals With Mild Hypercholesterolemia | American Journal of Therapeutics | 2007 | 112 |
| 31 | Telomere Length is a Biomarker of Cumulative Oxidative Stress, Biologic Age, and an Independent Predictor of Survival and Therapeutic Treatment Requirement Associated With Smoking Behavior | American Journal of Therapeutics | 2011 | 111 |
| 32 | Genetic and Genomic Studies of the BTBR ob/ob Mouse Model of Type 2 Diabetes | American Journal of Therapeutics | 2005 | 108 |
| 33 | Prevention of Atrial Fibrillation by Way of Abrogation of the Renin-Angiotensin System: A Systematic Review and Meta-Analysis | American Journal of Therapeutics | 2008 | 108 |
| 34 | Sublingual Buprenorphine Is Effective in the Treatment of Chronic Pain Syndrome | American Journal of Therapeutics | 2005 | 107 |
| 35 | Oxidative Stress and Pancreatic β-Cell Dysfunction | American Journal of Therapeutics | 2005 | 106 |
| 36 | Bioavailability and Pharmacokinetics of Magnesium After Administration of Magnesium Salts to Humans | American Journal of Therapeutics | 2001 | 105 |
| 37 | Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19 | American Journal of Therapeutics | 2021 | 103 |
| 38 | Use of Corticosteroids in Early Pregnancy is Not Associated With Risk of Oral Clefts and Other Congenital Malformations in Offspring | American Journal of Therapeutics | 2014 | 100 |
| 39 | Advanced Glycation End Products and Diabetic Nephropathy | American Journal of Therapeutics | 2005 | 95 |
| 40 | Opioid-Induced Hyperalgesia and Tolerance | American Journal of Therapeutics | 2010 | 95 |
| 41 | Adverse Events Associated With the Treatment of Multidrug-Resistant Tuberculosis | American Journal of Therapeutics | 2016 | 92 |
| 42 | Therapeutic Misadventure with Paracetamol | American Journal of Therapeutics | 2000 | 90 |
| 43 | Monitored Anesthesia Care With a Combination of Ketamine and Dexmedetomidine During Cardiac Catheterization | American Journal of Therapeutics | 2008 | 87 |
| 44 | Lidocaine Patch Treatment in Patients with Low Back Pain: Results of an Open-Label, Nonrandomized Pilot Study | American Journal of Therapeutics | 2005 | 86 |
| 45 | Trastuzumab: targeted therapy for the management of HER-2/neu-overexpressing metastatic breast cancer | American Journal of Therapeutics | 2005 | 85 |
| 46 | THE COLD PRESSOR TEST | American Journal of Therapeutics | 1997 | 84 |
| 47 | The ‘Forgotten’ Bile Acid Sequestrants: Is Now a Good Time to Remember? | American Journal of Therapeutics | 2007 | 84 |
| 48 | Biological and Chemical Agents: A Brief Synopsis | American Journal of Therapeutics | 2002 | 83 |
| 49 | Acetaminophen, Aspirin, or Ibuprofen in Combination Analgesic Products | American Journal of Therapeutics | 2001 | 82 |
| 50 | A Phase IIIb, Randomized, Double-blind, Placebo-controlled, Multicenter Study Evaluating the Safety and Efficacy of Dexmedetomidine for Sedation During Awake Fiberoptic Intubation | American Journal of Therapeutics | 2010 | 82 |
