| # | Title | Journal | Year | Citations |
|---|
| 1 | The Emerging Hallmarks of Cancer Metabolism | Cell Metabolism | 2016 | 3,943 |
| 2 | The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation | Cell Metabolism | 2008 | 3,421 |
| 3 | HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia | Cell Metabolism | 2006 | 3,112 |
| 4 | A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance | Cell Metabolism | 2009 | 2,597 |
| 5 | AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism | Cell Metabolism | 2005 | 2,541 |
| 6 | miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting | Cell Metabolism | 2006 | 1,969 |
| 7 | HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption | Cell Metabolism | 2006 | 1,919 |
| 8 | Metabolic control through the PGC-1 family of transcription coactivators | Cell Metabolism | 2005 | 1,826 |
| 9 | The biology of incretin hormones | Cell Metabolism | 2006 | 1,824 |
| 10 | Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism | Cell Metabolism | 2016 | 1,734 |
| 11 | Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation | Cell Metabolism | 2011 | 1,727 |
| 12 | Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist | Cell Metabolism | 2013 | 1,671 |
| 13 | Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance | Cell Metabolism | 2008 | 1,618 |
| 14 | FoxO3 Controls Autophagy in Skeletal Muscle In Vivo | Cell Metabolism | 2007 | 1,614 |
| 15 | NF-κB, Inflammation, and Metabolic Disease | Cell Metabolism | 2011 | 1,564 |
| 16 | Autophagy Is Required to Maintain Muscle Mass | Cell Metabolism | 2009 | 1,554 |
| 17 | Transcriptional control of adipocyte formation | Cell Metabolism | 2006 | 1,549 |
| 18 | Cellular Fatty Acid Metabolism and Cancer | Cell Metabolism | 2013 | 1,520 |
| 19 | Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis | Cell Metabolism | 2005 | 1,514 |
| 20 | Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation | Cell Metabolism | 2013 | 1,502 |
| 21 | Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet | Cell Metabolism | 2012 | 1,500 |
| 22 | TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis | Cell Metabolism | 2009 | 1,465 |
| 23 | The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon | Cell Metabolism | 2011 | 1,424 |
| 24 | Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase | Cell Metabolism | 2005 | 1,397 |
| 25 | AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice | Cell Metabolism | 2011 | 1,356 |
| 26 | Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing | Cell Metabolism | 2005 | 1,321 |
| 27 | Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21 | Cell Metabolism | 2007 | 1,306 |
| 28 | Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States | Cell Metabolism | 2007 | 1,305 |
| 29 | One-Carbon Metabolism in Health and Disease | Cell Metabolism | 2017 | 1,275 |
| 30 | FoxO3 Coordinately Activates Protein Degradation by the Autophagic/Lysosomal and Proteasomal Pathways in Atrophying Muscle Cells | Cell Metabolism | 2007 | 1,269 |
| 31 | High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice | Cell Metabolism | 2007 | 1,265 |
| 32 | SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function | Cell Metabolism | 2012 | 1,251 |
| 33 | Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes | Cell Metabolism | 2020 | 1,207 |
| 34 | Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells | Cell Metabolism | 2005 | 1,202 |
| 35 | Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella | Cell Metabolism | 2015 | 1,190 |
| 36 | Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes | Cell Metabolism | 2016 | 1,173 |
| 37 | NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus | Cell Metabolism | 2015 | 1,153 |
| 38 | Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation | Cell Metabolism | 2010 | 1,142 |
| 39 | UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality | Cell Metabolism | 2009 | 1,136 |
| 40 | LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells | Cell Metabolism | 2016 | 1,126 |
| 41 | PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties | Cell Metabolism | 2007 | 1,125 |
| 42 | Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation | Cell Metabolism | 2006 | 1,103 |
| 43 | SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth | Cell Metabolism | 2008 | 1,103 |
| 44 | Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action | Cell Metabolism | 2013 | 1,088 |
| 45 | Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance | Cell Metabolism | 2010 | 1,079 |
| 46 | Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans | Cell Metabolism | 2011 | 1,072 |
| 47 | The GLUT4 Glucose Transporter | Cell Metabolism | 2007 | 1,069 |
| 48 | Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span | Cell Metabolism | 2008 | 1,060 |
| 49 | Glucose Restriction Extends Caenorhabditis elegans Life Span by Inducing Mitochondrial Respiration and Increasing Oxidative Stress | Cell Metabolism | 2007 | 1,051 |
| 50 | Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance | Cell Metabolism | 2007 | 1,048 |
