| # | Title | Journal | Year | Citations |
|---|
| 1 | Clinicopathologic study of dextran sulfate sodium experimental murine colitis | Laboratory Investigation | 1993 | 990 |
| 2 | Neutrophils: Molecules, Functions and Pathophysiological Aspects | Laboratory Investigation | 2000 | 911 |
| 3 | The role of shear stress in the pathogenesis of atherosclerosis | Laboratory Investigation | 2005 | 891 |
| 4 | Generation of endogenous hydrogen sulfide by cystathionine γ-lyase limits renal ischemia/reperfusion injury and dysfunction | Laboratory Investigation | 2008 | 745 |
| 5 | Validation of Tissue Microarray Technology in Breast Carcinoma | Laboratory Investigation | 2000 | 714 |
| 6 | Programmed death ligand-1 expression in non-small cell lung cancer | Laboratory Investigation | 2014 | 697 |
| 7 | Biology of disease: free radicals and tissue injury | Laboratory Investigation | 1982 | 689 |
| 8 | Lipopolysaccharide signaling in endothelial cells | Laboratory Investigation | 2006 | 502 |
| 9 | Normalization of gene expression measurements in tumor tissues: comparison of 13 endogenous control genes | Laboratory Investigation | 2005 | 482 |
| 10 | MRP6 (ABCC6) Detection in Normal Human Tissues and Tumors | Laboratory Investigation | 2002 | 458 |
| 11 | Diversity in cell surface sialic acid presentations: implications for biology and disease | Laboratory Investigation | 2007 | 454 |
| 12 | CD68/macrosialin: not just a histochemical marker | Laboratory Investigation | 2017 | 447 |
| 13 | Community-acquired methicillin-resistant Staphylococcus aureus: the role of Panton–Valentine leukocidin | Laboratory Investigation | 2007 | 441 |
| 14 | miR-21 plays a pivotal role in gastric cancer pathogenesis and progression | Laboratory Investigation | 2008 | 434 |
| 15 | A porous defense: the leaky epithelial barrier in intestinal disease | Laboratory Investigation | 2004 | 423 |
| 16 | Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells | Laboratory Investigation | 2005 | 400 |
| 17 | Immune microenvironment of gliomas | Laboratory Investigation | 2017 | 398 |
| 18 | Heterogeneity of the Angiogenic Response Induced in Different Normal Adult Tissues by Vascular Permeability Factor/Vascular Endothelial Growth Factor | Laboratory Investigation | 2000 | 384 |
| 19 | The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses | Laboratory Investigation | 2007 | 383 |
| 20 | Apoptotic Body Engulfment by a Human Stellate Cell Line Is Profibrogenic | Laboratory Investigation | 2003 | 370 |
| 21 | Pathobiology of transforming growth factor β in cancer, fibrosis and immunologic disease, and therapeutic considerations | Laboratory Investigation | 2007 | 370 |
| 22 | M2-polarized tumor-associated macrophages promoted epithelial–mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway | Laboratory Investigation | 2013 | 370 |
| 23 | A New Monoclonal Antibody, D2-40, for Detection of Lymphatic Invasion in Primary Tumors | Laboratory Investigation | 2002 | 368 |
| 24 | Plasma microRNAs as potential biomarkers for non-small-cell lung cancer | Laboratory Investigation | 2011 | 361 |
| 25 | Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion | Laboratory Investigation | 2006 | 349 |
| 26 | Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing | Laboratory Investigation | 1990 | 341 |
| 27 | IL-33 can promote survival, adhesion and cytokine production in human mast cells | Laboratory Investigation | 2007 | 336 |
| 28 | MALDI Imaging mass spectrometry: current frontiers and perspectives in pathology research and practice | Laboratory Investigation | 2015 | 334 |
| 29 | Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities | Laboratory Investigation | 1987 | 334 |
| 30 | Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion | Laboratory Investigation | 2011 | 330 |
| 31 | Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status | Laboratory Investigation | 2010 | 327 |
| 32 | ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome | Laboratory Investigation | 2010 | 321 |
| 33 | Normal and Pathologic Soft Tissue Remodeling: Role of the Myofibroblast, with Special Emphasis on Liver and Kidney Fibrosis | Laboratory Investigation | 2003 | 313 |
| 34 | Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas | Laboratory Investigation | 2008 | 312 |
| 35 | Derivation of male germ cells from bone marrow stem cells | Laboratory Investigation | 2006 | 307 |
| 36 | In Vitro Models of Vasculogenesis and Angiogenesis | Laboratory Investigation | 2001 | 301 |
| 37 | Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene | Laboratory Investigation | 2005 | 301 |
| 38 | Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation | Laboratory Investigation | 2008 | 297 |
| 39 | Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma | Laboratory Investigation | 2004 | 293 |
| 40 | A great majority of GISTs with PDGFRA mutations represent gastric tumors of low or no malignant potential | Laboratory Investigation | 2004 | 292 |
| 41 | Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium | Laboratory Investigation | 1983 | 291 |
| 42 | Short Telomeres in Patients with Vascular Dementia: An Indicator of Low Antioxidative Capacity and a Possible Risk Factor? | Laboratory Investigation | 2000 | 290 |
| 43 | Myocyte Death in Streptozotocin-Induced Diabetes in Rats Is Angiotensin II- Dependent | Laboratory Investigation | 2000 | 287 |
| 44 | Apoptosis Induced In Vitro and In Vivo During Infection by Ebola and Marburg Viruses | Laboratory Investigation | 2000 | 282 |
| 45 | Inhibition of Monocyte Chemotactic Protein-1 Synthesis by Statins | Laboratory Investigation | 2000 | 282 |
| 46 | Pathogenesis of inflammatory periodontal disease. A summary of current work | Laboratory Investigation | 1976 | 282 |
| 47 | Engineering and Characterization of Functional Human Microvessels in Immunodeficient Mice | Laboratory Investigation | 2001 | 280 |
| 48 | Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood–retinal barrier | Laboratory Investigation | 2005 | 280 |
| 49 | Macrophage-Induced Apoptosis Limits Endovascular Trophoblast Invasion in the Uterine Wall of Preeclamptic Women | Laboratory Investigation | 2001 | 276 |
| 50 | Tumor invasion and the extracellular matrix | Laboratory Investigation | 1983 | 276 |
