6.2(top 2%)
impact factor
3.4K(top 5%)
papers
241.3K(top 2%)
citations
207(top 1%)
h-index
6.3(top 2%)
impact factor
3.8K
all documents
252.9K
doc citations
314(top 2%)
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Top Articles

#TitleJournalYearCitations
1DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial DrugsChemistry and Biology20101,507
2Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural productsChemistry and Biology19981,471
3A DNA enzyme that cleaves RNAChemistry and Biology19941,242
4Vitamin D Metabolism, Mechanism of Action, and Clinical ApplicationsChemistry and Biology20141,221
5Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer CellsChemistry and Biology20081,200
6The specificity-conferring code of adenylation domains in nonribosomal peptide synthetasesChemistry and Biology19991,096
7Proteasome inhibitors: from research tools to drug candidatesChemistry and Biology20011,053
8A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2-ArachidonoylglycerolChemistry and Biology2007971
9An Engineered Protein Tag for Multiprotein Labeling in Living CellsChemistry and Biology2008940
10DNA-enhanced peroxidase activity of a DNA aptamer-hemin complexChemistry and Biology1998903
11Stattic: A Small-Molecule Inhibitor of STAT3 Activation and DimerizationChemistry and Biology2006899
12Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the RealityChemistry and Biology2014865
13Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide–polyketide synthetase systemChemistry and Biology2000852
14Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4Chemistry and Biology2015843
15Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcriptionChemistry and Biology2000815
16RNA-Based Therapeutics: Current Progress and Future ProspectsChemistry and Biology2012804
17A new enzyme superfamily — the phosphopantetheinyl transferasesChemistry and Biology1996746
18Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domainsChemistry and Biology2000746
19GSK-3-Selective Inhibitors Derived from Tyrian Purple IndirubinsChemistry and Biology2003720
20Profiling Enzyme Activities In Vivo Using Click Chemistry MethodsChemistry and Biology2004702
21Genetic Control by a Metabolite Binding mRNAChemistry and Biology2002686
22Catalytic promiscuity and the evolution of new enzymatic activitiesChemistry and Biology1999657
23Unmodified Cadmium Telluride Quantum Dots Induce Reactive Oxygen Species Formation Leading to Multiple Organelle Damage and Cell DeathChemistry and Biology2005656
24Observation of metastable Aβ amyloid protofibrils by atomic force microscopyChemistry and Biology1997644
25The Process of Structure-Based Drug DesignChemistry and Biology2003632
26Click Chemistry in Complex Mixtures: Bioorthogonal BioconjugationChemistry and Biology2014627
27Molecular recognition of the inhibitor AG-1343 by HIV-1 protease: conformationally flexible docking by evolutionary programmingChemistry and Biology1995622
28Droplet-Based Microfluidic Platforms for the Encapsulation and Screening of Mammalian Cells and Multicellular OrganismsChemistry and Biology2008620
29Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNAChemistry and Biology1997614
30Win some, lose some: enthalpy-entropy compensation in weak intermolecular interactionsChemistry and Biology1995592
31Features of Selective Kinase InhibitorsChemistry and Biology2005582
32Developing Irreversible Inhibitors of the Protein Kinase CysteinomeChemistry and Biology2013563
33Chemical Ecology of Endophytic Fungi: Origins of Secondary MetabolitesChemistry and Biology2012562
34Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule InhibitorChemistry and Biology2010538
35Chemistry-Based Functional Proteomics Reveals Novel Members of the Deubiquitinating Enzyme FamilyChemistry and Biology2002533
36Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery toolsChemistry and Biology2000530
37Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical BiologyChemistry and Biology2012523
38Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical CandidatesChemistry and Biology2014523
39The Binding Avidity of a Nanoparticle-Based Multivalent Targeted Drug Delivery PlatformChemistry and Biology2007521
40Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNAChemistry and Biology2001519
41Deacetylase EnzymesChemistry and Biology2002513
42A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal DeliveryChemistry and Biology2011507
43Structural Basis for Discriminative Regulation of Gene Expression by Adenine- and Guanine-Sensing mRNAsChemistry and Biology2004505
44Matrix metal loproteinases and the development of cancerChemistry and Biology1996498
45Designing Chemically Modified Oligonucleotides for Targeted Gene SilencingChemistry and Biology2012495
46Immunization with Peptide-Functionalized Carbon Nanotubes Enhances Virus-Specific Neutralizing Antibody ResponsesChemistry and Biology2003492
47Glycyrrhizin Binds to High-Mobility Group Box 1 Protein and Inhibits Its Cytokine ActivitiesChemistry and Biology2007484
48Carbohydrate Arrays for the Evaluation of Protein Binding and Enzymatic ModificationChemistry and Biology2002480
49Mitomycin C: small, fast and deadly (but very selective)Chemistry and Biology1995476
50Biocompatible Quantum Dots for Biological ApplicationsChemistry and Biology2011476