# | Title | Journal | Year | Citations |
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1 | DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs | Chemistry and Biology | 2010 | 1,507 |
2 | Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products | Chemistry and Biology | 1998 | 1,471 |
3 | A DNA enzyme that cleaves RNA | Chemistry and Biology | 1994 | 1,242 |
4 | Vitamin D Metabolism, Mechanism of Action, and Clinical Applications | Chemistry and Biology | 2014 | 1,221 |
5 | Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells | Chemistry and Biology | 2008 | 1,200 |
6 | The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases | Chemistry and Biology | 1999 | 1,096 |
7 | Proteasome inhibitors: from research tools to drug candidates | Chemistry and Biology | 2001 | 1,053 |
8 | A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2-Arachidonoylglycerol | Chemistry and Biology | 2007 | 971 |
9 | An Engineered Protein Tag for Multiprotein Labeling in Living Cells | Chemistry and Biology | 2008 | 940 |
10 | DNA-enhanced peroxidase activity of a DNA aptamer-hemin complex | Chemistry and Biology | 1998 | 903 |
11 | Stattic: A Small-Molecule Inhibitor of STAT3 Activation and Dimerization | Chemistry and Biology | 2006 | 899 |
12 | Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality | Chemistry and Biology | 2014 | 865 |
13 | Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide–polyketide synthetase system | Chemistry and Biology | 2000 | 852 |
14 | Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4 | Chemistry and Biology | 2015 | 843 |
15 | Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription | Chemistry and Biology | 2000 | 815 |
16 | RNA-Based Therapeutics: Current Progress and Future Prospects | Chemistry and Biology | 2012 | 804 |
17 | A new enzyme superfamily — the phosphopantetheinyl transferases | Chemistry and Biology | 1996 | 746 |
18 | Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains | Chemistry and Biology | 2000 | 746 |
19 | GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins | Chemistry and Biology | 2003 | 720 |
20 | Profiling Enzyme Activities In Vivo Using Click Chemistry Methods | Chemistry and Biology | 2004 | 702 |
21 | Genetic Control by a Metabolite Binding mRNA | Chemistry and Biology | 2002 | 686 |
22 | Catalytic promiscuity and the evolution of new enzymatic activities | Chemistry and Biology | 1999 | 657 |
23 | Unmodified Cadmium Telluride Quantum Dots Induce Reactive Oxygen Species Formation Leading to Multiple Organelle Damage and Cell Death | Chemistry and Biology | 2005 | 656 |
24 | Observation of metastable Aβ amyloid protofibrils by atomic force microscopy | Chemistry and Biology | 1997 | 644 |
25 | The Process of Structure-Based Drug Design | Chemistry and Biology | 2003 | 632 |
26 | Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation | Chemistry and Biology | 2014 | 627 |
27 | Molecular recognition of the inhibitor AG-1343 by HIV-1 protease: conformationally flexible docking by evolutionary programming | Chemistry and Biology | 1995 | 622 |
28 | Droplet-Based Microfluidic Platforms for the Encapsulation and Screening of Mammalian Cells and Multicellular Organisms | Chemistry and Biology | 2008 | 620 |
29 | Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA | Chemistry and Biology | 1997 | 614 |
30 | Win some, lose some: enthalpy-entropy compensation in weak intermolecular interactions | Chemistry and Biology | 1995 | 592 |
31 | Features of Selective Kinase Inhibitors | Chemistry and Biology | 2005 | 582 |
32 | Developing Irreversible Inhibitors of the Protein Kinase Cysteinome | Chemistry and Biology | 2013 | 563 |
33 | Chemical Ecology of Endophytic Fungi: Origins of Secondary Metabolites | Chemistry and Biology | 2012 | 562 |
34 | Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor | Chemistry and Biology | 2010 | 538 |
35 | Chemistry-Based Functional Proteomics Reveals Novel Members of the Deubiquitinating Enzyme Family | Chemistry and Biology | 2002 | 533 |
36 | Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools | Chemistry and Biology | 2000 | 530 |
37 | Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology | Chemistry and Biology | 2012 | 523 |
38 | Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates | Chemistry and Biology | 2014 | 523 |
39 | The Binding Avidity of a Nanoparticle-Based Multivalent Targeted Drug Delivery Platform | Chemistry and Biology | 2007 | 521 |
40 | Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA | Chemistry and Biology | 2001 | 519 |
41 | Deacetylase Enzymes | Chemistry and Biology | 2002 | 513 |
42 | A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal Delivery | Chemistry and Biology | 2011 | 507 |
43 | Structural Basis for Discriminative Regulation of Gene Expression by Adenine- and Guanine-Sensing mRNAs | Chemistry and Biology | 2004 | 505 |
44 | Matrix metal loproteinases and the development of cancer | Chemistry and Biology | 1996 | 498 |
45 | Designing Chemically Modified Oligonucleotides for Targeted Gene Silencing | Chemistry and Biology | 2012 | 495 |
46 | Immunization with Peptide-Functionalized Carbon Nanotubes Enhances Virus-Specific Neutralizing Antibody Responses | Chemistry and Biology | 2003 | 492 |
47 | Glycyrrhizin Binds to High-Mobility Group Box 1 Protein and Inhibits Its Cytokine Activities | Chemistry and Biology | 2007 | 484 |
48 | Carbohydrate Arrays for the Evaluation of Protein Binding and Enzymatic Modification | Chemistry and Biology | 2002 | 480 |
49 | Mitomycin C: small, fast and deadly (but very selective) | Chemistry and Biology | 1995 | 476 |
50 | Biocompatible Quantum Dots for Biological Applications | Chemistry and Biology | 2011 | 476 |