| # | Title | Journal | Year | Citations |
|---|
| 1 | Exploring the full spectrum of macrophage activation | Nature Reviews Immunology | 2008 | 7,332 |
| 2 | Toll-like receptor signalling | Nature Reviews Immunology | 2004 | 7,318 |
| 3 | Myeloid-derived suppressor cells as regulators of the immune system | Nature Reviews Immunology | 2009 | 5,655 |
| 4 | Alternative activation of macrophages | Nature Reviews Immunology | 2003 | 5,300 |
| 5 | Exosomes: composition, biogenesis and function | Nature Reviews Immunology | 2002 | 4,401 |
| 6 | Monocyte and macrophage heterogeneity | Nature Reviews Immunology | 2005 | 4,366 |
| 7 | Protective and pathogenic functions of macrophage subsets | Nature Reviews Immunology | 2011 | 4,050 |
| 8 | Neutrophil recruitment and function in health and inflammation | Nature Reviews Immunology | 2013 | 3,964 |
| 9 | The gut microbiota shapes intestinal immune responses during health and disease | Nature Reviews Immunology | 2009 | 3,946 |
| 10 | Sex differences in immune responses | Nature Reviews Immunology | 2016 | 3,615 |
| 11 | Toll-like receptors and innate immunity | Nature Reviews Immunology | 2001 | 3,573 |
| 12 | NF-κB regulation in the immune system | Nature Reviews Immunology | 2002 | 3,568 |
| 13 | Getting to the site of inflammation: the leukocyte adhesion cascade updated | Nature Reviews Immunology | 2007 | 3,547 |
| 14 | Membrane vesicles as conveyors of immune responses | Nature Reviews Immunology | 2009 | 3,386 |
| 15 | Adipokines in inflammation and metabolic disease | Nature Reviews Immunology | 2011 | 3,378 |
| 16 | The trinity of COVID-19: immunity, inflammation and intervention | Nature Reviews Immunology | 2020 | 3,347 |
| 17 | Interleukin-12 and the regulation of innate resistance and adaptive immunity | Nature Reviews Immunology | 2003 | 3,274 |
| 18 | Molecular and cellular insights into T cell exhaustion | Nature Reviews Immunology | 2015 | 3,159 |
| 19 | Mesenchymal stem cells in health and disease | Nature Reviews Immunology | 2008 | 3,028 |
| 20 | Coordinated regulation of myeloid cells by tumours | Nature Reviews Immunology | 2012 | 3,002 |
| 21 | Intestinal mucosal barrier function in health and disease | Nature Reviews Immunology | 2009 | 2,795 |
| 22 | Type 2 diabetes as an inflammatory disease | Nature Reviews Immunology | 2011 | 2,777 |
| 23 | Mechanisms of type-I- and type-II-interferon-mediated signalling | Nature Reviews Immunology | 2005 | 2,758 |
| 24 | NF-κB: linking inflammation and immunity to cancer development and progression | Nature Reviews Immunology | 2005 | 2,745 |
| 25 | NOX enzymes and the biology of reactive oxygen | Nature Reviews Immunology | 2004 | 2,723 |
| 26 | Defensins: antimicrobial peptides of innate immunity | Nature Reviews Immunology | 2003 | 2,647 |
| 27 | How regulatory T cells work | Nature Reviews Immunology | 2008 | 2,638 |
| 28 | Adipocytokines: mediators linking adipose tissue, inflammation and immunity | Nature Reviews Immunology | 2006 | 2,618 |
| 29 | The NLRP3 inflammasome: molecular activation and regulation to therapeutics | Nature Reviews Immunology | 2019 | 2,601 |
| 30 | Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators | Nature Reviews Immunology | 2008 | 2,492 |
| 31 | Sterile inflammation: sensing and reacting to damage | Nature Reviews Immunology | 2010 | 2,469 |
| 32 | The regulation of IL-10 production by immune cells | Nature Reviews Immunology | 2010 | 2,408 |
| 33 | Fcγ receptors as regulators of immune responses | Nature Reviews Immunology | 2008 | 2,406 |
| 34 | Regulation of type I interferon responses | Nature Reviews Immunology | 2014 | 2,400 |
| 35 | Neutrophils and immunity: challenges and opportunities | Nature Reviews Immunology | 2006 | 2,394 |
| 36 | Molecular mechanisms of T cell co-stimulation and co-inhibition | Nature Reviews Immunology | 2013 | 2,382 |
| 37 | Activation and regulation of the inflammasomes | Nature Reviews Immunology | 2013 | 2,373 |
| 38 | Signalling pathways of the TNF superfamily: a double-edged sword | Nature Reviews Immunology | 2003 | 2,358 |
| 39 | Inflammasomes: mechanism of assembly, regulation and signalling | Nature Reviews Immunology | 2016 | 2,353 |
| 40 | The role of inflammation in depression: from evolutionary imperative to modern treatment target | Nature Reviews Immunology | 2016 | 2,350 |
| 41 | Neutrophils in the activation and regulation of innate and adaptive immunity | Nature Reviews Immunology | 2011 | 2,306 |
| 42 | The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling | Nature Reviews Immunology | 2007 | 2,285 |
| 43 | Monocyte recruitment during infection and inflammation | Nature Reviews Immunology | 2011 | 2,272 |
| 44 | High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal | Nature Reviews Immunology | 2005 | 2,218 |
| 45 | Gut microbiota, metabolites and host immunity | Nature Reviews Immunology | 2016 | 2,212 |
| 46 | A guide to cancer immunotherapy: from T cell basic science to clinical practice | Nature Reviews Immunology | 2020 | 2,160 |
| 47 | Intestinal epithelial cells: regulators of barrier function and immune homeostasis | Nature Reviews Immunology | 2014 | 2,123 |
| 48 | Cytokines in the pathogenesis of rheumatoid arthritis | Nature Reviews Immunology | 2007 | 2,106 |
| 49 | A guide to immunometabolism for immunologists | Nature Reviews Immunology | 2016 | 2,100 |
| 50 | Ido expression by dendritic cells: tolerance and tryptophan catabolism | Nature Reviews Immunology | 2004 | 2,071 |
