| # | Title | Journal | Year | Citations |
|---|
| 1 | Network pharmacology: the next paradigm in drug discovery | Nature Chemical Biology | 2008 | 3,165 |
| 2 | N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO | Nature Chemical Biology | 2011 | 2,936 |
| 3 | Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury | Nature Chemical Biology | 2005 | 2,411 |
| 4 | A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation | Nature Chemical Biology | 2014 | 2,342 |
| 5 | ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition | Nature Chemical Biology | 2017 | 2,069 |
| 6 | Reconciling the chemistry and biology of reactive oxygen species | Nature Chemical Biology | 2008 | 1,998 |
| 7 | Networking by small-molecule hormones in plant immunity | Nature Chemical Biology | 2009 | 1,987 |
| 8 | Identification of RIP1 kinase as a specific cellular target of necrostatins | Nature Chemical Biology | 2008 | 1,708 |
| 9 | The role of iron and reactive oxygen species in cell death | Nature Chemical Biology | 2014 | 1,685 |
| 10 | The role of dynamic conformational ensembles in biomolecular recognition | Nature Chemical Biology | 2009 | 1,649 |
| 11 | Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis | Nature Chemical Biology | 2017 | 1,589 |
| 12 | Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli | Nature Chemical Biology | 2009 | 1,588 |
| 13 | The function of terpene natural products in the natural world | Nature Chemical Biology | 2007 | 1,564 |
| 14 | Chemistry and biology of reactive oxygen species in signaling or stress responses | Nature Chemical Biology | 2011 | 1,461 |
| 15 | Mass spectrometry–based proteomics turns quantitative | Nature Chemical Biology | 2005 | 1,426 |
| 16 | Chemistry in living systems | Nature Chemical Biology | 2005 | 1,290 |
| 17 | Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer | Nature Chemical Biology | 2009 | 1,259 |
| 18 | Targeting virulence: a new paradigm for antimicrobial therapy | Nature Chemical Biology | 2007 | 1,159 |
| 19 | Mechanisms for copper acquisition, distribution and regulation | Nature Chemical Biology | 2008 | 1,145 |
| 20 | Targeting mitochondria metabolism for cancer therapy | Nature Chemical Biology | 2015 | 1,107 |
| 21 | Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors | Nature Chemical Biology | 2005 | 1,088 |
| 22 | Synthetic fluorescent sensors for studying the cell biology of metals | Nature Chemical Biology | 2008 | 1,011 |
| 23 | Rational design of inhibitors that bind to inactive kinase conformations | Nature Chemical Biology | 2006 | 985 |
| 24 | Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol | Nature Chemical Biology | 2011 | 984 |
| 25 | RNAi therapeutics: a potential new class of pharmaceutical drugs | Nature Chemical Biology | 2006 | 968 |
| 26 | Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism | Nature Chemical Biology | 2008 | 930 |
| 27 | The role of iron regulatory proteins in mammalian iron homeostasis and disease | Nature Chemical Biology | 2006 | 906 |
| 28 | Catalytic in vivo protein knockdown by small-molecule PROTACs | Nature Chemical Biology | 2015 | 879 |
| 29 | Foldamers as versatile frameworks for the design and evolution of function | Nature Chemical Biology | 2007 | 839 |
| 30 | (+)-7-iso-Jasmonoyl-L-isoleucine is the endogenous bioactive jasmonate | Nature Chemical Biology | 2009 | 822 |
| 31 | Target identification and mechanism of action in chemical biology and drug discovery | Nature Chemical Biology | 2013 | 814 |
| 32 | Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects | Nature Chemical Biology | 2009 | 804 |
| 33 | Structural basis of PROTAC cooperative recognition for selective protein degradation | Nature Chemical Biology | 2017 | 758 |
| 34 | Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin | Nature Chemical Biology | 2010 | 757 |
| 35 | Amyloid formation by globular proteins under native conditions | Nature Chemical Biology | 2009 | 746 |
| 36 | Natural strategies for photosynthetic light harvesting | Nature Chemical Biology | 2014 | 745 |
| 37 | Novel targets for Huntington's disease in an mTOR-independent autophagy pathway | Nature Chemical Biology | 2008 | 739 |
| 38 | Virtual and biomolecular screening converge on a selective agonist for GPR30 | Nature Chemical Biology | 2006 | 730 |
| 39 | Minimum Information about a Biosynthetic Gene cluster | Nature Chemical Biology | 2015 | 715 |
| 40 | Identification of lysine succinylation as a new post-translational modification | Nature Chemical Biology | 2011 | 698 |
| 41 | A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells | Nature Chemical Biology | 2012 | 698 |
| 42 | The promise and peril of chemical probes | Nature Chemical Biology | 2015 | 698 |
| 43 | Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited | Nature Chemical Biology | 2006 | 695 |
| 44 | Directed evolution drives the next generation of biocatalysts | Nature Chemical Biology | 2009 | 689 |
| 45 | Plant hormones are versatile chemical regulators of plant growth | Nature Chemical Biology | 2009 | 686 |
| 46 | Making carbon-nitrogen bonds in biological and chemical synthesis | Nature Chemical Biology | 2006 | 680 |
| 47 | An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translation | Nature Chemical Biology | 2007 | 676 |
| 48 | Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis | Nature Chemical Biology | 2016 | 671 |
| 49 | Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation | Nature Chemical Biology | 2011 | 649 |
| 50 | Chemical phylogenetics of histone deacetylases | Nature Chemical Biology | 2010 | 646 |
