# | Title | Journal | Year | Citations |
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1 | HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis | ACS Chemical Biology | 2008 | 1,913 |
2 | Engineered Luciferase Reporter from a Deep Sea Shrimp Utilizing a Novel Imidazopyrazinone Substrate | ACS Chemical Biology | 2012 | 1,229 |
3 | Bright Ideas for Chemical Biology | ACS Chemical Biology | 2008 | 1,085 |
4 | NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells | ACS Chemical Biology | 2016 | 935 |
5 | Describing the Mechanism of Antimicrobial Peptide Action with the Interfacial Activity Model | ACS Chemical Biology | 2010 | 786 |
6 | Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4 | ACS Chemical Biology | 2015 | 744 |
7 | Drugging Topoisomerases: Lessons and Challenges | ACS Chemical Biology | 2013 | 698 |
8 | A Comparative Study of Bioorthogonal Reactions with Azides | ACS Chemical Biology | 2006 | 647 |
9 | Chemical Biology of Peroxynitrite: Kinetics, Diffusion, and Radicals | ACS Chemical Biology | 2009 | 647 |
10 | Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death | ACS Chemical Biology | 2015 | 629 |
11 | Why Nature Chose Selenium | ACS Chemical Biology | 2016 | 621 |
12 | Finding the Right (Bioorthogonal) Chemistry | ACS Chemical Biology | 2014 | 589 |
13 | Cellobiose Dehydrogenase and a Copper-Dependent Polysaccharide Monooxygenase Potentiate Cellulose Degradation by Neurospora crassa | ACS Chemical Biology | 2011 | 568 |
14 | Advances in the Biology and Chemistry of Sialic Acids | ACS Chemical Biology | 2010 | 467 |
15 | Bioorthogonal Reactions for Labeling Proteins | ACS Chemical Biology | 2014 | 467 |
16 | Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations | ACS Chemical Biology | 2018 | 444 |
17 | Orchestrating Redox Signaling Networks through Regulatory Cysteine Switches | ACS Chemical Biology | 2010 | 430 |
18 | Critical Fluctuations in Plasma Membrane Vesicles | ACS Chemical Biology | 2008 | 420 |
19 | Bright Building Blocks for Chemical Biology | ACS Chemical Biology | 2014 | 413 |
20 | An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1 | ACS Chemical Biology | 2013 | 399 |
21 | Synthetic Biology for Synthetic Chemistry | ACS Chemical Biology | 2008 | 383 |
22 | Illuminating the Chemistry of Life: Design, Synthesis, and Applications of “Caged” and Related Photoresponsive Compounds | ACS Chemical Biology | 2009 | 383 |
23 | Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors | ACS Chemical Biology | 2016 | 364 |
24 | In Vivo Structure−Activity Relationship Study of Dorsomorphin Analogues Identifies Selective VEGF and BMP Inhibitors | ACS Chemical Biology | 2010 | 361 |
25 | Conformational Dynamics in the Acyl-CoA Synthetases, Adenylation Domains of Non-ribosomal Peptide Synthetases, and Firefly Luciferase | ACS Chemical Biology | 2009 | 360 |
26 | NanoBRET—A Novel BRET Platform for the Analysis of Protein–Protein Interactions | ACS Chemical Biology | 2015 | 360 |
27 | Kinase Drug Discovery – What’s Next in the Field? | ACS Chemical Biology | 2013 | 344 |
28 | Evolution of Group 14 Rhodamines as Platforms for Near-Infrared Fluorescence Probes Utilizing Photoinduced Electron Transfer | ACS Chemical Biology | 2011 | 339 |
29 | RNA Mango Aptamer-Fluorophore: A Bright, High-Affinity Complex for RNA Labeling and Tracking | ACS Chemical Biology | 2014 | 338 |
30 | Exploration of Type II Binding Mode: A Privileged Approach for Kinase Inhibitor Focused Drug Discovery? | ACS Chemical Biology | 2014 | 337 |
31 | ANS Binding Reveals Common Features of Cytotoxic Amyloid Species | ACS Chemical Biology | 2010 | 335 |
32 | Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease | ACS Chemical Biology | 2013 | 329 |
33 | HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins | ACS Chemical Biology | 2015 | 321 |
34 | Use of Artificial Intelligence in the Design of Small Peptide Antibiotics Effective against a Broad Spectrum of Highly Antibiotic-Resistant Superbugs | ACS Chemical Biology | 2009 | 303 |
35 | Aminoglycoside Antibiotics in the 21st Century | ACS Chemical Biology | 2013 | 300 |
36 | Strategies and Approaches of Targeting STAT3 for Cancer Treatment | ACS Chemical Biology | 2016 | 297 |
37 | Novel Pentameric Thiophene Derivatives for in Vitro and in Vivo Optical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses | ACS Chemical Biology | 2009 | 290 |
38 | Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers | ACS Chemical Biology | 2020 | 280 |
39 | Synthetic Lethal Compound Combinations Reveal a Fundamental Connection between Wall Teichoic Acid and Peptidoglycan Biosyntheses in Staphylococcus aureus | ACS Chemical Biology | 2011 | 276 |
40 | Playing with the Molecules of Life | ACS Chemical Biology | 2018 | 270 |
41 | Recent Advances in Developing Small Molecules Targeting RNA | ACS Chemical Biology | 2012 | 266 |
42 | Metabolic Regulation of Histone Post-Translational Modifications | ACS Chemical Biology | 2015 | 259 |
43 | Mining the Thiol Proteome for Sulfenic Acid Modifications Reveals New Targets for Oxidation in Cells | ACS Chemical Biology | 2009 | 258 |
44 | CRISPR-Mediated Tagging of Endogenous Proteins with a Luminescent Peptide | ACS Chemical Biology | 2018 | 251 |
45 | Direct and Rapid Cytosolic Delivery Using Cell-Penetrating Peptides Mediated by Pyrenebutyrate | ACS Chemical Biology | 2006 | 250 |
46 | CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine | ACS Chemical Biology | 2018 | 248 |
47 | Identification of Direct Protein Targets of Small Molecules | ACS Chemical Biology | 2011 | 247 |
48 | Exploring the Structural Diversity of Mammalian Carbohydrates (“Glycospace”) by Statistical Databank Analysis | ACS Chemical Biology | 2007 | 245 |
49 | Selective Tumor Cell Targeting Using Low-Affinity, Multivalent Interactions | ACS Chemical Biology | 2007 | 244 |
50 | Hydrocarbon Stapled Peptides as Modulators of Biological Function | ACS Chemical Biology | 2015 | 244 |