| # | Title | Journal | Year | Citations |
|---|
| 1 | Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration | Glia | 2007 | 1,778 |
| 2 | Microglia as a source and target of cytokines | Glia | 2002 | 1,436 |
| 3 | Astrocyte activation and reactive gliosis | Glia | 2005 | 1,384 |
| 4 | Immune function of astrocytes | Glia | 2001 | 1,136 |
| 5 | Immune function of microglia | Glia | 2001 | 1,126 |
| 6 | Astrocyte glutamate transport: Review of properties, regulation, and physiological functions | Glia | 2000 | 1,057 |
| 7 | Cytotoxicity of microglia | Glia | 1993 | 1,016 |
| 8 | Functional plasticity of microglia: A review | Glia | 1988 | 916 |
| 9 | Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro | Glia | 2002 | 879 |
| 10 | Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease | Glia | 1993 | 828 |
| 11 | Microglia as neuroprotective, immunocompetent cells of the CNS | Glia | 2002 | 815 |
| 12 | Matrix metalloproteinases in neuroinflammation | Glia | 2002 | 777 |
| 13 | Activity‐dependent regulation of energy metabolism by astrocytes: An update | Glia | 2007 | 696 |
| 14 | The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction | Glia | 2010 | 689 |
| 15 | The origin and nature of ramified and amoeboid microglia: A historical review and current concepts | Glia | 1993 | 640 |
| 16 | Microglia and neurodegeneration: The role of systemic inflammation | Glia | 2013 | 626 |
| 17 | The brain tumor microenvironment | Glia | 2012 | 624 |
| 18 | Microglia in degenerative neurological disease | Glia | 1993 | 574 |
| 19 | Microglia derived from aging mice exhibit an altered inflammatory profile | Glia | 2007 | 570 |
| 20 | Astrocyte calcium waves: What they are and what they do | Glia | 2006 | 568 |
| 21 | Dystrophic microglia in the aging human brain | Glia | 2004 | 567 |
| 22 | New functions of Müller cells | Glia | 2013 | 564 |
| 23 | Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation | Glia | 2005 | 546 |
| 24 | Toll‐like receptor 4 is required for α‐synuclein dependent activation of microglia and astroglia | Glia | 2013 | 542 |
| 25 | High-yield isolation of murine microglia by mild trypsinization | Glia | 2003 | 529 |
| 26 | Dynamics of microglial activation: A confocal time-lapse analysis in hippocampal slices | Glia | 2001 | 514 |
| 27 | GFAP promoter-controlled EGFP-expressing transgenic mice: A tool to visualize astrocytes and astrogliosis in living brain tissue | Glia | 2001 | 488 |
| 28 | Astrocyte glycogen and brain energy metabolism | Glia | 2007 | 484 |
| 29 | Astroglia in CNS injury | Glia | 1991 | 483 |
| 30 | Oligodendrocytes and myelination: The role of iron | Glia | 2009 | 483 |
| 31 | Human bone marrow‐derived mesenchymal stem cells induce Th2‐polarized immune response and promote endogenous repair in animal models of multiple sclerosis | Glia | 2009 | 478 |
| 32 | Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll‐like receptor‐mediated neuronal injury | Glia | 2010 | 474 |
| 33 | Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury | Glia | 2004 | 469 |
| 34 | The glia/neuron ratio: How it varies uniformly across brain structures and species and what that means for brain physiology and evolution | Glia | 2014 | 461 |
| 35 | The “quad‐partite” synapse: Microglia‐synapse interactions in the developing and mature CNS | Glia | 2013 | 458 |
| 36 | Astrocyte glutamate transport: review of properties, regulation, and physiological functions | Glia | 2000 | 447 |
| 37 | Cannabinoid and cannabinoid‐like receptors in microglia, astrocytes, and astrocytomas | Glia | 2010 | 442 |
| 38 | Basic principles of immunological surveillance of the normal central nervous system | Glia | 2001 | 439 |
| 39 | Negative regulation of myelination: Relevance for development, injury, and demyelinating disease | Glia | 2008 | 430 |
| 40 | The brain tumor microenvironment | Glia | 2011 | 425 |
| 41 | Glial influence on the blood brain barrier | Glia | 2013 | 424 |
| 42 | Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons | Glia | 2005 | 421 |
| 43 | Multiple roles for MMPs and TIMPs in cerebral ischemia | Glia | 2005 | 401 |
| 44 | Sequential activation of microglia and astrocyte cytokine expression precedes increased iba‐1 or GFAP immunoreactivity following systemic immune challenge | Glia | 2016 | 401 |
| 45 | Microglial control of neuronal death and synaptic properties | Glia | 2007 | 396 |
| 46 | Neuroinflammation in Alzheimer's disease and prion disease | Glia | 2002 | 393 |
| 47 | Comparison of polarization properties of human adult microglia and blood‐derived macrophages | Glia | 2012 | 393 |
| 48 | Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88‐dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways | Glia | 2011 | 390 |
| 49 | Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease | Glia | 2010 | 385 |
| 50 | Glial cell lineage in the cerebral cortex: A review and synthesis | Glia | 1991 | 384 |
