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Human Gene Therapy
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top-articles
Human Gene Therapy
3.0
(top 20%)
impact factor
4.7K
(top 5%)
papers
210.6K
(top 2%)
citations
173
(top 2%)
h
-index
3.3
(top 10%)
impact factor
5.7K
all documents
220.0K
doc citations
244
(top 2%)
g
-index
Top Articles
#
Title
Journal
Year
Citations
1
High Levels of Foreign Gene Expression in Hepatocytes after Tail Vein Injections of Naked Plasmid DNA
Human Gene Therapy
1999
912
2
Treatment of Leber Congenital Amaurosis Due to
RPE65
Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial
Human Gene Therapy
2008
880
3
Prevalence of Serum IgG and Neutralizing Factors Against Adeno-Associated Virus (AAV) Types 1, 2, 5, 6, 8, and 9 in the Healthy Population: Implications for Gene Therapy Using AAV Vectors
Human Gene Therapy
2010
776
4
Episomal Vectors Rapidly and Stably Produce High-Titer Recombinant Retrovirus
Human Gene Therapy
1996
689
5
A Phase III Clinical Evaluation of Herpes Simplex Virus Type 1 Thymidine Kinase and Ganciclovir Gene Therapy as an Adjuvant to Surgical Resection and Radiation in Adults with Previously Untreated Glioblastoma Multiforme
Human Gene Therapy
2000
648
6
Novel Tools for Production and Purification of Recombinant Adenoassociated Virus Vectors
Human Gene Therapy
1998
641
7
Activation of the Complement System by Synthetic DNA Complexes: A Potential Barrier for Intravenous Gene Delivery
Human Gene Therapy
1996
572
8
Nonviral Vectors in the New Millennium: Delivery Barriers in Gene Transfer
Human Gene Therapy
2001
550
9
Severe Toxicity in Nonhuman Primates and Piglets Following High-Dose Intravenous Administration of an Adeno-Associated Virus Vector Expressing Human SMN
Human Gene Therapy
2018
543
10
A Powerful Nonviral Vector for
In Vivo
Gene Transfer into the Adult Mammalian Brain: Polyethylenimine
Human Gene Therapy
1996
518
11
Characterization of 911: A New Helper Cell Line for the Titration and Propagation of Early Region 1-Deleted Adenoviral Vectors
Human Gene Therapy
1996
493
12
Innate Immune Mechanisms Dominate Elimination of Adenoviral Vectors Following
In Vivo
Administration
Human Gene Therapy
1997
480
13
Quantitative Analysis of the Packaging Capacity of Recombinant Adeno-Associated Virus
Human Gene Therapy
1996
476
14
High-Level Transduction and Gene Expression in Hematopoietic Repopulating Cells Using a Human Imunodeficiency Virus Type 1-Based Lentiviral Vector Containing an Internal Spleen Focus Forming Virus Promoter
Human Gene Therapy
2002
457
15
Nonviral Gene Therapy: The Promise of Genes as Pharmaceutical Products
Human Gene Therapy
1995
455
16
Detailed Analysis of Structures and Formulations of Cationic Lipids for Efficient Gene Transfer to the Lung
Human Gene Therapy
1996
453
17
New Helper Cells and Matched Early Region 1-Deleted Adenovirus Vectors Prevent Generation of Replication-Competent Adenoviruses
Human Gene Therapy
1998
445
18
Nomenclature for Synthetic Gene Delivery Systems
Human Gene Therapy
1997
444
19
Adenoviral Gene Therapy Leads to Rapid Induction of Multiple Chemokines and Acute Neutrophil-Dependent Hepatic Injury in Vivo
Human Gene Therapy
1999
440
20
Gene Therapy by Intramuscular Injection of Plasmid DNA: Studies on Firefly Luciferase Gene Expression in Mice
Human Gene Therapy
1993
438
21
In Vitro
Evidence That Metabolic Cooperation Is Responsible for the Bystander Effect Observed with HSV
tk
Retroviral Gene Therapy
Human Gene Therapy
1993
421
22
Retrovirus Packaging Cells
Human Gene Therapy
1990
411
23
Gene Therapy for the Treatment of Brain Tumors Using Intra-Tumoral Transduction with the Thymidine Kinase Gene and Intravenous Ganciclovir. National Institutes of Health
Human Gene Therapy
1993
410
24
Insect Cells as a Factory to Produce Adeno-Associated Virus Type 2 Vectors
Human Gene Therapy
2002
409
25
Improved Methods of Retroviral Vector Transduction and Production for Gene Therapy
Human Gene Therapy
1994
396
26
PEGylation of Adenovirus with Retention of Infectivity and Protection from Neutralizing Antibody in Vitro and in Vivo
Human Gene Therapy
1999
390
27
Direct Gene Transfer into Skeletal Muscle
In Vivo
: Factors Affecting Efficiency of Transfer and Stability of Expression
Human Gene Therapy
1993
389
28
Systematic Determination of the Packaging Limit of Lentiviral Vectors
Human Gene Therapy
2001
380
29
Current Status of Gendicine in China: Recombinant Human Ad-p53 Agent for Treatment of Cancers
Human Gene Therapy
2005
376
30
The Innate Immune Response to Adenovirus Vectors
Human Gene Therapy
2004
371
31
Characterization of Vectors for Gene Therapy Formed by Self-Assembly of DNA with Synthetic Block Co-Polymers
Human Gene Therapy
1996
370
32
Treatment of Late Infantile Neuronal Ceroid Lipofuscinosis by CNS Administration of a Serotype 2 Adeno-Associated Virus Expressing CLN2 cDNA
Human Gene Therapy
2008
366
33
Bone Marrow Mesenchymal Stem Cells: Historical Overview and Concepts
Human Gene Therapy
2010
350
34
Evaluation of the Transfer and Expression in Mice of an Enzyme-Encoding Gene Using a Human Adenovirus Vector
Human Gene Therapy
1990
346
35
Adenovirus-Mediated Transfer of the CFTR Gene to Lung of Nonhuman Primates: Toxicity Study
Human Gene Therapy
1993
338
36
A Pilot Study ofIn VivoLiver-Directed Gene Transfer with an Adenoviral Vector in Partial Ornithine Transcarbamylase Deficiency
Human Gene Therapy
2002
337
37
Adenoviral Vector-Delivered Pigment Epithelium-Derived Factor for Neovascular Age-Related Macular Degeneration: Results of a Phase I Clinical Trial
Human Gene Therapy
2006
336
38
Mutagenesis and Oncogenesis by Chromosomal Insertion of Gene Transfer Vectors
Human Gene Therapy
2006
335
39
An Improved Plasmid DNA Expression Vector for Direct Injection into Skeletal Muscle
Human Gene Therapy
1996
333
40
Silencing and Variegation of Gammaretrovirus and Lentivirus Vectors
Human Gene Therapy
2005
333
41
Efficient Construction of a Recombinant Adenovirus Vector by an Improved
In Vitro
Ligation Method
Human Gene Therapy
1998
329
42
Adenovirus-Mediated Herpes Simplex Virus Thymidine Kinase/Ganciclovir Gene Therapy in Patients with Localized Malignancy: Results of a Phase I Clinical Trial in Malignant Mesothelioma
Human Gene Therapy
1998
328
43
Assessment of Recombinant Adenoviral Vectors for Hepatic Gene Therapy
Human Gene Therapy
1993
327
44
Ultrasound-Mediated Transfection of Mammalian Cells
Human Gene Therapy
1996
327
45
Highly Purified Recombinant Adeno-Associated Virus Vectors Are Biologically Active and Free of Detectable Helper and Wild-Type Viruses
Human Gene Therapy
1999
312
46
The Regulation of Differentiation in Mesenchymal Stem Cells
Human Gene Therapy
2010
312
47
A Novel Three-Pronged Approach to Kill Cancer Cells Selectively: Concomitant Viral, Double Suicide Gene, and Radiotherapy
Human Gene Therapy
1998
305
48
Human
RPE65
Gene Therapy for Leber Congenital Amaurosis: Persistence of Early Visual Improvements and Safety at 1 Year
Human Gene Therapy
2009
305
49
Promoter Attenuation in Gene Therapy: Interferon-
γ
and Tumor Necrosis Factor-
α
Inhibit Transgene Expression
Human Gene Therapy
1997
302
50
In Vivo
Nasal Potential Difference: Techniques and Protocols for Assessing Efficacy of Gene Transfer in Cystic Fibrosis
Human Gene Therapy
1995
301
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