| # | Title | Journal | Year | Citations |
|---|
| 1 | The amygdala: vigilance and emotion | Molecular Psychiatry | 2001 | 2,557 |
| 2 | The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication | Molecular Psychiatry | 2010 | 1,995 |
| 3 | The autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism | Molecular Psychiatry | 2014 | 1,882 |
| 4 | Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence | Molecular Psychiatry | 2005 | 1,859 |
| 5 | The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner | Molecular Psychiatry | 2013 | 1,445 |
| 6 | Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism | Molecular Psychiatry | 2016 | 1,397 |
| 7 | A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression | Molecular Psychiatry | 2016 | 1,197 |
| 8 | Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states | Molecular Psychiatry | 2002 | 1,121 |
| 9 | A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder | Molecular Psychiatry | 2008 | 1,107 |
| 10 | Mechanisms of fear extinction | Molecular Psychiatry | 2007 | 1,084 |
| 11 | Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice | Molecular Psychiatry | 2009 | 1,084 |
| 12 | A mega-analysis of genome-wide association studies for major depressive disorder | Molecular Psychiatry | 2013 | 1,002 |
| 13 | MAOA, maltreatment, and gene–environment interaction predicting children's mental health: new evidence and a meta-analysis | Molecular Psychiatry | 2006 | 999 |
| 14 | Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies | Molecular Psychiatry | 2022 | 967 |
| 15 | Vulnerability genes or plasticity genes? | Molecular Psychiatry | 2009 | 913 |
| 16 | Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it? | Molecular Psychiatry | 2012 | 883 |
| 17 | Dopamine in drug abuse and addiction: results from imaging studies and treatment implications | Molecular Psychiatry | 2004 | 870 |
| 18 | Mental disorders, comorbidity and suicidal behavior: Results from the National Comorbidity Survey Replication | Molecular Psychiatry | 2010 | 870 |
| 19 | Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs | Molecular Psychiatry | 2005 | 867 |
| 20 | The neurodevelopmental model of schizophrenia: update 2005 | Molecular Psychiatry | 2005 | 864 |
| 21 | Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group | Molecular Psychiatry | 2017 | 852 |
| 22 | Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group | Molecular Psychiatry | 2016 | 850 |
| 23 | Adult brain neurogenesis and psychiatry: a novel theory of depression | Molecular Psychiatry | 2000 | 849 |
| 24 | Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium | Molecular Psychiatry | 2016 | 820 |
| 25 | Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress | Molecular Psychiatry | 2004 | 810 |
| 26 | De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia | Molecular Psychiatry | 2012 | 775 |
| 27 | Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α | Molecular Psychiatry | 2016 | 775 |
| 28 | Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia | Molecular Psychiatry | 2002 | 738 |
| 29 | Deep brain stimulation of the ventral internal capsule/ventral striatum for obsessive-compulsive disorder: worldwide experience | Molecular Psychiatry | 2010 | 728 |
| 30 | The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine | Molecular Psychiatry | 2006 | 709 |
| 31 | The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings | Molecular Psychiatry | 2005 | 708 |
| 32 | Microbiota is essential for social development in the mouse | Molecular Psychiatry | 2014 | 708 |
| 33 | Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis | Molecular Psychiatry | 2012 | 694 |
| 34 | The GABAergic deficit hypothesis of major depressive disorder | Molecular Psychiatry | 2011 | 687 |
| 35 | Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies | Molecular Psychiatry | 2007 | 683 |
| 36 | From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways | Molecular Psychiatry | 2016 | 683 |
| 37 | The vascular depression hypothesis: mechanisms linking vascular disease with depression | Molecular Psychiatry | 2013 | 671 |
| 38 | Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers | Molecular Psychiatry | 1999 | 670 |
| 39 | Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response | Molecular Psychiatry | 2004 | 661 |
| 40 | Neurodevelopmental model of schizophrenia: update 2012 | Molecular Psychiatry | 2012 | 652 |
| 41 | Mechanisms of ketamine action as an antidepressant | Molecular Psychiatry | 2018 | 646 |
| 42 | Whole-genome association study of bipolar disorder | Molecular Psychiatry | 2008 | 642 |
| 43 | The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers | Molecular Psychiatry | 1998 | 639 |
| 44 | Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression | Molecular Psychiatry | 2008 | 638 |
| 45 | Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles | Molecular Psychiatry | 2008 | 635 |
| 46 | A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder | Molecular Psychiatry | 2008 | 619 |
| 47 | Genetics of attention deficit hyperactivity disorder | Molecular Psychiatry | 2019 | 614 |
| 48 | Gene–environment interaction analysis of serotonin system markers with adolescent depression | Molecular Psychiatry | 2004 | 612 |
| 49 | Early experience and serotonin transporter gene variation interact to influence primate CNS function | Molecular Psychiatry | 2002 | 601 |
| 50 | Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine | Molecular Psychiatry | 1998 | 599 |
