# | Title | Journal | Year | Citations |
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1 | The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors | Nature Immunology | 2010 | 7,320 |
2 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells | Nature Immunology | 2003 | 6,653 |
3 | Cancer immunoediting: from immunosurveillance to tumor escape | Nature Immunology | 2002 | 4,290 |
4 | Toll-like receptors: critical proteins linking innate and acquired immunity | Nature Immunology | 2001 | 4,209 |
5 | Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages | Nature Immunology | 2005 | 4,106 |
6 | A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 | Nature Immunology | 2005 | 3,869 |
7 | Toll-like receptor control of the adaptive immune responses | Nature Immunology | 2004 | 3,662 |
8 | The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses | Nature Immunology | 2004 | 3,433 |
9 | T cell exhaustion | Nature Immunology | 2011 | 3,178 |
10 | Innate and adaptive immune cells in the tumor microenvironment | Nature Immunology | 2013 | 3,109 |
11 | Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm | Nature Immunology | 2010 | 3,073 |
12 | Functions of natural killer cells | Nature Immunology | 2008 | 3,070 |
13 | Complement: a key system for immune surveillance and homeostasis | Nature Immunology | 2010 | 2,990 |
14 | Nitric oxide and the immune response | Nature Immunology | 2001 | 2,838 |
15 | NF-κB at the crossroads of life and death | Nature Immunology | 2002 | 2,611 |
16 | Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization | Nature Immunology | 2008 | 2,568 |
17 | An essential role for Scurfin in CD4+CD25+ T regulatory cells | Nature Immunology | 2003 | 2,525 |
18 | PD-L2 is a second ligand for PD-1 and inhibits T cell activation | Nature Immunology | 2001 | 2,504 |
19 | Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome | Nature Immunology | 2011 | 2,447 |
20 | Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self | Nature Immunology | 2005 | 2,417 |
21 | IKKε and TBK1 are essential components of the IRF3 signaling pathway | Nature Immunology | 2003 | 2,361 |
22 | Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage | Nature Immunology | 2019 | 2,330 |
23 | Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway | Nature Immunology | 2002 | 2,290 |
24 | IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction | Nature Immunology | 2005 | 2,254 |
25 | Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria | Nature Immunology | 2001 | 2,239 |
26 | Thioredoxin-interacting protein links oxidative stress to inflammasome activation | Nature Immunology | 2010 | 2,163 |
27 | Resolution of inflammation: the beginning programs the end | Nature Immunology | 2005 | 2,060 |
28 | The NALP3 inflammasome is involved in the innate immune response to amyloid-β | Nature Immunology | 2008 | 2,047 |
29 | IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways | Nature Immunology | 2007 | 1,873 |
30 | Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP | Nature Immunology | 2002 | 1,847 |
31 | The immune system in atherosclerosis | Nature Immunology | 2011 | 1,825 |
32 | IL-6 as a keystone cytokine in health and disease | Nature Immunology | 2015 | 1,825 |
33 | Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells | Nature Immunology | 2010 | 1,811 |
34 | Development, cytokine profile and function of human interleukin 17–producing helper T cells | Nature Immunology | 2007 | 1,795 |
35 | Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection | Nature Immunology | 2009 | 1,754 |
36 | Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages | Nature Immunology | 2012 | 1,731 |
37 | The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity | Nature Immunology | 2005 | 1,697 |
38 | IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex | Nature Immunology | 2003 | 1,670 |
39 | Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells | Nature Immunology | 2007 | 1,670 |
40 | Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells | Nature Immunology | 2007 | 1,660 |
41 | Innate immune recognition of viral infection | Nature Immunology | 2006 | 1,654 |
42 | Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule | Nature Immunology | 2000 | 1,626 |
43 | Lineage relationship and protective immunity of memory CD8 T cell subsets | Nature Immunology | 2003 | 1,621 |
44 | Tissue-resident macrophages | Nature Immunology | 2013 | 1,621 |
45 | Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells | Nature Immunology | 2003 | 1,605 |
46 | A function for interleukin 2 in Foxp3-expressing regulatory T cells | Nature Immunology | 2005 | 1,577 |
47 | The Immunological Genome Project: networks of gene expression in immune cells | Nature Immunology | 2008 | 1,576 |
48 | The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis | Nature Immunology | 2009 | 1,568 |
49 | Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance | Nature Immunology | 2002 | 1,566 |
50 | Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice | Nature Immunology | 2007 | 1,523 |