| # | Title | Journal | Year | Citations |
|---|
| 1 | Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells | Cancer Science | 2005 | 1,680 |
| 2 | Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis | Cancer Science | 2010 | 1,180 |
| 3 | Signaling networks guiding epithelial–mesenchymal transitions during embryogenesis and cancer progression | Cancer Science | 2007 | 722 |
| 4 | Epithelial–mesenchymal transition in cancer development and its clinical significance | Cancer Science | 2010 | 691 |
| 5 | Cell adhesion system and human cancer morphogenesis | Cancer Science | 2003 | 654 |
| 6 | Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and1B1 | Cancer Science | 2004 | 640 |
| 7 | A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate | Cancer Science | 2003 | 632 |
| 8 | Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target? | Cancer Science | 2019 | 614 |
| 9 | Reduced expression of Dicer associated with poor prognosis in lung cancer patients | Cancer Science | 2005 | 573 |
| 10 | Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish | Cancer Science | 2004 | 567 |
| 11 | Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer | Cancer Science | 2007 | 554 |
| 12 | Regulation of cancer cell motility through actin reorganization | Cancer Science | 2005 | 541 |
| 13 | Carbohydrate-mediated cell adhesion in cancer metastasis and angiogenesis | Cancer Science | 2004 | 540 |
| 14 | Oncolytic virus therapy: A new era of cancer treatment at dawn | Cancer Science | 2016 | 527 |
| 15 | Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage | Cancer Science | 2004 | 518 |
| 16 | Emerging roles of long non‐coding RNA in cancer | Cancer Science | 2018 | 489 |
| 17 | Cancer/testis (CT) antigens: Potential targets for immunotherapy | Cancer Science | 2009 | 478 |
| 18 | Preclinical and clinical studies of anticancer agent‐incorporating polymer micelles | Cancer Science | 2009 | 474 |
| 19 | ADAMs in cancer cell proliferation and progression | Cancer Science | 2007 | 472 |
| 20 | Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal | Cancer Science | 2003 | 461 |
| 21 | Role of iron in carcinogenesis: Cancer as a ferrotoxic disease | Cancer Science | 2009 | 461 |
| 22 | YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor‐2 tyrosine kinase with potent activity in vitro and in vivo | Cancer Science | 2011 | 433 |
| 23 | Clinical significance of macrophage heterogeneity in human malignant tumors | Cancer Science | 2014 | 425 |
| 24 | Bystander killing effect of DS‐8201a, a novel anti‐human epidermal growth factor receptor 2 antibody–drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity | Cancer Science | 2016 | 394 |
| 25 | Epidemiology of cholangiocarcinoma: An update focusing on risk factors | Cancer Science | 2010 | 385 |
| 26 | Basic mechanisms of high‐risk human papillomavirus‐induced carcinogenesis: Roles of E6 and E7 proteins | Cancer Science | 2007 | 380 |
| 27 | Genetic alterations and signaling pathways in the evolution of gliomas | Cancer Science | 2009 | 374 |
| 28 | Mechanism and biological significance of CD44 cleavage | Cancer Science | 2004 | 359 |
| 29 | Tumor‐derived spheroids: Relevance to cancer stem cells and clinical applications | Cancer Science | 2017 | 357 |
| 30 | Functional roles of N‐glycans in cell signaling and cell adhesion in cancer | Cancer Science | 2008 | 351 |
| 31 | Tumor hypoxia: A target for selective cancer therapy | Cancer Science | 2003 | 329 |
| 32 | Molecular links between tumor angiogenesis and inflammation: inflammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy | Cancer Science | 2008 | 315 |
| 33 | Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers | Cancer Science | 2008 | 311 |
| 34 | Nectins and nectin-like molecules: Roles in cell adhesion, migration, and polarization | Cancer Science | 2003 | 308 |
| 35 | Not all epidermal growth factor receptor mutations in lung cancer are created equal: Perspectives for individualized treatment strategy | Cancer Science | 2016 | 305 |
| 36 | Intracellular zinc homeostasis and zinc signaling | Cancer Science | 2008 | 304 |
| 37 | Lipoxygenase‐mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3 | Cancer Science | 2017 | 303 |
| 38 | Overexpression of yes‐associated protein contributes to progression and poor prognosis of non‐small‐cell lung cancer | Cancer Science | 2010 | 302 |
| 39 | Aminopeptidase N (CD13) as a target for cancer chemotherapy | Cancer Science | 2011 | 293 |
| 40 | The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta | Cancer Science | 2005 | 291 |
| 41 | Signal transduction of inflammatory cytokines and tumor development | Cancer Science | 2006 | 286 |
| 42 | Novel combination of serum microRNA for detecting breast cancer in the early stage | Cancer Science | 2016 | 274 |
| 43 | Downregulation of microRNAs‐143 and ‐145 in B‐cell malignancies | Cancer Science | 2007 | 271 |
| 44 | Exosomes in cancer development and clinical applications | Cancer Science | 2018 | 271 |
| 45 | Salt, salted food intake, and risk of gastric cancer: Epidemiologic evidence | Cancer Science | 2005 | 268 |
| 46 | Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis | Cancer Science | 2008 | 264 |
| 47 | Association of a novel long non‐coding RNA in 8q24 with prostate cancer susceptibility | Cancer Science | 2011 | 263 |
| 48 | Role of the miR‐106b‐25 microRNA cluster in hepatocellular carcinoma | Cancer Science | 2009 | 262 |
| 49 | Detailed characterization of the mouse glioma 261 tumor model for experimental glioblastoma therapy | Cancer Science | 2006 | 260 |
| 50 | Molecular functions and biological roles of hepatitis B virus x protein | Cancer Science | 2006 | 259 |
