# | Title | Journal | Year | Citations |
---|
1 | The growing impact of click chemistry on drug discovery | Drug Discovery Today | 2003 | 2,880 |
2 | Peptide therapeutics: current status and future directions | Drug Discovery Today | 2015 | 2,250 |
3 | PEGylation, successful approach to drug delivery | Drug Discovery Today | 2005 | 2,029 |
4 | Ligand efficiency: a useful metric for lead selection | Drug Discovery Today | 2004 | 1,687 |
5 | Exploiting the enhanced permeability and retention effect for tumor targeting | Drug Discovery Today | 2006 | 1,633 |
6 | Natural products in drug discovery | Drug Discovery Today | 2008 | 1,507 |
7 | Hydrogels: from controlled release to pH-responsive drug delivery | Drug Discovery Today | 2002 | 1,484 |
8 | Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications | Drug Discovery Today | 2001 | 1,453 |
9 | Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs | Drug Discovery Today | 2007 | 1,262 |
10 | Dendrimers and dendritic polymers in drug delivery | Drug Discovery Today | 2005 | 1,247 |
11 | Synthetic therapeutic peptides: science and market | Drug Discovery Today | 2010 | 1,215 |
12 | A ‘Rule of Three’ for fragment-based lead discovery? | Drug Discovery Today | 2003 | 1,209 |
13 | The rise of deep learning in drug discovery | Drug Discovery Today | 2018 | 1,033 |
14 | Blood–brain barrier delivery | Drug Discovery Today | 2007 | 995 |
15 | Three-dimensional cell culture: the missing link in drug discovery | Drug Discovery Today | 2013 | 983 |
16 | Nanotech approaches to drug delivery and imaging | Drug Discovery Today | 2003 | 980 |
17 | Multi-target therapeutics: when the whole is greater than the sum of the parts | Drug Discovery Today | 2007 | 947 |
18 | Virtual screening—an overview | Drug Discovery Today | 1998 | 905 |
19 | Photodynamic therapeutics: basic principles and clinical applications | Drug Discovery Today | 1999 | 801 |
20 | Silver nanoparticles: synthesis, properties, and therapeutic applications | Drug Discovery Today | 2015 | 723 |
21 | Similarity-based virtual screening using 2D fingerprints | Drug Discovery Today | 2006 | 722 |
22 | Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications | Drug Discovery Today | 2010 | 707 |
23 | From magic bullets to designed multiple ligands | Drug Discovery Today | 2004 | 672 |
24 | Pancreatic lipase inhibitors from natural sources: unexplored potential | Drug Discovery Today | 2007 | 668 |
25 | Cell-penetrating peptides: classes, origin, and current landscape | Drug Discovery Today | 2012 | 668 |
26 | Pharmacophore modeling and applications in drug discovery: challenges and recent advances | Drug Discovery Today | 2010 | 654 |
27 | Angiogenesis and bone repair | Drug Discovery Today | 2003 | 645 |
28 | The role of cocrystals in pharmaceutical science | Drug Discovery Today | 2008 | 643 |
29 | The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design? | Drug Discovery Today | 2009 | 637 |
30 | Drugs from the deep: marine natural products as drug candidates | Drug Discovery Today | 2003 | 635 |
31 | Future directions for peptide therapeutics development | Drug Discovery Today | 2013 | 633 |
32 | Machine learning in chemoinformatics and drug discovery | Drug Discovery Today | 2018 | 630 |
33 | Keynote review: Phosphodiesterase-4 as a therapeutic target | Drug Discovery Today | 2005 | 604 |
34 | Virtual ligand screening: strategies, perspectives and limitations | Drug Discovery Today | 2006 | 598 |
35 | Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival | Drug Discovery Today | 2012 | 589 |
36 | An analysis of FDA-approved drugs: natural products and their derivatives | Drug Discovery Today | 2016 | 572 |
37 | Curcumin nanoformulations: a future nanomedicine for cancer | Drug Discovery Today | 2012 | 569 |
38 | Enantioselective organocatalysis | Drug Discovery Today | 2007 | 561 |
39 | Machine-learning approaches in drug discovery: methods and applications | Drug Discovery Today | 2015 | 559 |
40 | Structure-based virtual screening: an overview | Drug Discovery Today | 2002 | 556 |
41 | Computational methods for the prediction of ‘drug-likeness’ | Drug Discovery Today | 2000 | 552 |
42 | Cancer nanotechnology: application of nanotechnology in cancer therapy | Drug Discovery Today | 2010 | 550 |
43 | Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs | Drug Discovery Today | 2009 | 542 |
44 | What made sesquiterpene lactones reach cancer clinical trials? | Drug Discovery Today | 2010 | 536 |
45 | Nanonization strategies for poorly water-soluble drugs | Drug Discovery Today | 2011 | 525 |
46 | Zinc oxide nanoparticles: a promising nanomaterial for biomedical applications | Drug Discovery Today | 2017 | 520 |
47 | PTP1B as a drug target: recent developments in PTP1B inhibitor discovery | Drug Discovery Today | 2007 | 505 |
48 | Ligand efficiency indices as guideposts for drug discovery | Drug Discovery Today | 2005 | 501 |
49 | Artificial intelligence in drug discovery and development | Drug Discovery Today | 2021 | 501 |
50 | Managing the drug discovery/development interface | Drug Discovery Today | 1997 | 489 |