# | Title | Journal | Year | Citations |
---|
1 | The matrix-degrading metalloproteinases | BioEssays | 1992 | 1,308 |
2 | The PARP superfamily | BioEssays | 2004 | 1,255 |
3 | Roles of histone acetyltransferases and deacetylases in gene regulation | BioEssays | 1998 | 1,068 |
4 | The tetratricopeptide repeat: a structural motif mediating protein-protein interactions | BioEssays | 1999 | 1,040 |
5 | Histone acetylation and an epigenetic code | BioEssays | 2000 | 1,027 |
6 | The structure and synthesis of the fungal cell wall | BioEssays | 2006 | 1,006 |
7 | Reactive oxygen species as signals that modulate plant stress responses and programmed cell death | BioEssays | 2006 | 951 |
8 | From 2R to 3R: evidence for a fish-specific genome duplication (FSGD) | BioEssays | 2005 | 929 |
9 | PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease | BioEssays | 2003 | 871 |
10 | Cyclin-dependent protein kinases: Key regulators of the eukaryotic cell cycle | BioEssays | 1995 | 866 |
11 | All for one and one for all: condensations and the initiation of skeletal development | BioEssays | 2000 | 790 |
12 | β-catenin signaling and cancer | BioEssays | 1999 | 787 |
13 | Ubiquitin-mediated proteolysis: biological regulation via destruction | BioEssays | 2000 | 764 |
14 | AMP-activated protein kinase: the energy charge hypothesis revisited | BioEssays | 2001 | 715 |
15 | Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function | BioEssays | 1995 | 711 |
16 | Protein kinase cascades activated by stress and inflammatory cytokines | BioEssays | 1996 | 705 |
17 | Specificity within the EGF family/ErbB receptor family signaling network | BioEssays | 1998 | 695 |
18 | FGFs, heparan sulfate and FGFRs: complex interactions essential for development | BioEssays | 2000 | 646 |
19 | The flavonoid biosynthetic pathway in plants: Function and evolution | BioEssays | 1994 | 637 |
20 | Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition | BioEssays | 2001 | 636 |
21 | Supramolecular assembly of basement membranes | BioEssays | 1996 | 630 |
22 | Phosphatidylinositol 3-kinase | BioEssays | 1994 | 601 |
23 | TRIM/RBCC, a novel class of ‘single protein RING finger’ E3 ubiquitin ligases | BioEssays | 2005 | 587 |
24 | The relationship between non-protein-coding DNA and eukaryotic complexity | BioEssays | 2007 | 578 |
25 | GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo | BioEssays | 2007 | 554 |
26 | Pattern formation by local self-activation and lateral inhibition | BioEssays | 2000 | 547 |
27 | Regulation of zygotic gene activation in the mouse | BioEssays | 1993 | 539 |
28 | The intestinal epithelial stem cell | BioEssays | 2002 | 524 |
29 | The H19 locus: Role of an imprinted non‐coding RNA in growth and development | BioEssays | 2010 | 518 |
30 | The ins and outs of lysophosphatidic acid signaling | BioEssays | 2004 | 514 |
31 | Glycosaminoglycan-protein interactions: definition of consensus sites in glycosaminoglycan binding proteins | BioEssays | 1998 | 502 |
32 | Animal models of Parkinson's disease | BioEssays | 2002 | 494 |
33 | 14-3-3 proteins: key regulators of cell division, signalling and apoptosis | BioEssays | 2001 | 493 |
34 | Challenging the dogma: the hidden layer of non-protein-coding RNAs in complex organisms | BioEssays | 2003 | 492 |
35 | High‐throughput DNA sequencing – concepts and limitations | BioEssays | 2010 | 490 |
36 | Calcium signalling and cell proliferation | BioEssays | 1995 | 489 |
37 | Reactive oxygen species generation and human spermatozoa: The balance of benefit and risk | BioEssays | 1994 | 486 |
38 | Regulation of male traits by testosterone: implications for the evolution of vertebrate life histories | BioEssays | 2007 | 478 |
39 | What is the total number of protein molecules per cell volume? A call to rethink some published values | BioEssays | 2013 | 477 |
40 | VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection | BioEssays | 2004 | 476 |
41 | Nuclear targeting signal recognition: a key control point in nuclear transport? | BioEssays | 2000 | 472 |
42 | Molecular principles of hair follicle induction and morphogenesis | BioEssays | 2005 | 465 |
43 | Animal evolution during domestication: the domesticated fox as a model | BioEssays | 2009 | 463 |
44 | Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era | BioEssays | 2004 | 451 |
45 | How reticulated are species? | BioEssays | 2016 | 449 |
46 | Signaling through focal adhesion kinase | BioEssays | 1997 | 448 |
47 | Probiotics function mechanistically as delivery vehicles for neuroactive compounds: Microbial endocrinology in the design and use of probiotics | BioEssays | 2011 | 445 |
48 | The pleiotropic functions of the Y-box-binding protein, YB-1 | BioEssays | 2003 | 444 |
49 | It's time to flower: the genetic control of flowering time | BioEssays | 2004 | 436 |
50 | The FEN-1 family of structure-specific nucleases in eukaryotic dna replication, recombination and repair | BioEssays | 1997 | 434 |