# | Title | Journal | Year | Citations |
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1 | Amyloid deposition as the central event in the aetiology of Alzheimer's disease | Trends in Pharmacological Sciences | 1991 | 2,091 |
2 | Drugs of abuse: anatomy, pharmacology and function of reward pathways | Trends in Pharmacological Sciences | 1992 | 1,943 |
3 | Excitatory amino acid neurotoxicity and neurodegenerative disease | Trends in Pharmacological Sciences | 1990 | 1,678 |
4 | Assessing antidepressant activity in rodents: recent developments and future needs | Trends in Pharmacological Sciences | 2002 | 1,373 |
5 | Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy | Trends in Pharmacological Sciences | 2012 | 1,271 |
6 | Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function | Trends in Pharmacological Sciences | 2006 | 1,237 |
7 | Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer | Trends in Pharmacological Sciences | 2009 | 1,097 |
8 | Current advances and trends in the treatment of depression | Trends in Pharmacological Sciences | 1994 | 1,040 |
9 | The release and uptake of excitatory amino acids | Trends in Pharmacological Sciences | 1990 | 989 |
10 | Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets | Trends in Pharmacological Sciences | 2009 | 940 |
11 | G-protein-coupled receptors and signaling networks: emerging paradigms | Trends in Pharmacological Sciences | 2001 | 933 |
12 | Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases | Trends in Pharmacological Sciences | 1989 | 898 |
13 | Molecular biology of dopamine receptors | Trends in Pharmacological Sciences | 1992 | 890 |
14 | FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition | Trends in Pharmacological Sciences | 2001 | 859 |
15 | Structure-activity relationships in the development of excitatory ammo acid receptor agonists and competitive antagonists | Trends in Pharmacological Sciences | 1990 | 846 |
16 | Excitatory amino acid receptors and synaptic plasticity | Trends in Pharmacological Sciences | 1990 | 835 |
17 | Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors | Trends in Pharmacological Sciences | 1990 | 830 |
18 | Zebrafish as an emerging model for studying complex brain disorders | Trends in Pharmacological Sciences | 2014 | 827 |
19 | Cell-Penetrating Peptides: From Basic Research to Clinics | Trends in Pharmacological Sciences | 2017 | 812 |
20 | Cell-penetrating peptides | Trends in Pharmacological Sciences | 2000 | 809 |
21 | Dopamine receptor pharmacology | Trends in Pharmacological Sciences | 1994 | 807 |
22 | FDA-approved small-molecule kinase inhibitors | Trends in Pharmacological Sciences | 2015 | 794 |
23 | Role of Ca2+ in toxic cell killing | Trends in Pharmacological Sciences | 1989 | 790 |
24 | Brain nicotinic acetylcholine receptors: native subtypes and their relevance | Trends in Pharmacological Sciences | 2006 | 782 |
25 | Targeting Free Radicals in Oxidative Stress-Related Human Diseases | Trends in Pharmacological Sciences | 2017 | 781 |
26 | Sickness behavior as a new target for drug development | Trends in Pharmacological Sciences | 1992 | 766 |
27 | Adipokines in health and disease | Trends in Pharmacological Sciences | 2015 | 766 |
28 | Neonicotinoids: insecticides acting on insect nicotinic acetylcholine receptors | Trends in Pharmacological Sciences | 2001 | 760 |
29 | Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins | Trends in Pharmacological Sciences | 1993 | 756 |
30 | The efficiency of multi-target drugs: the network approach might help drug design | Trends in Pharmacological Sciences | 2005 | 745 |
31 | EDHF: bringing the concepts together | Trends in Pharmacological Sciences | 2002 | 731 |
32 | Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb | Trends in Pharmacological Sciences | 2009 | 717 |
33 | Rho–Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells | Trends in Pharmacological Sciences | 2001 | 693 |
34 | Anti-inflammatory actions of steroids: molecular mechanisms | Trends in Pharmacological Sciences | 1993 | 687 |
35 | Metabotropic glutamate receptors in brain function and pathology | Trends in Pharmacological Sciences | 1993 | 683 |
36 | Neurosteroids and GABAA receptor function | Trends in Pharmacological Sciences | 1995 | 680 |
37 | Non-genomic and genomic effects of steroids on neural activity | Trends in Pharmacological Sciences | 1991 | 674 |
38 | Role of poly(ADP-ribose) synthetase in inflammation and ischaemia–reperfusion | Trends in Pharmacological Sciences | 1998 | 666 |
39 | Conformational complexity of G-protein-coupled receptors | Trends in Pharmacological Sciences | 2007 | 646 |
40 | PPARs: therapeutic targets for metabolic disease | Trends in Pharmacological Sciences | 2005 | 632 |
41 | β-arrestin-mediated receptor trafficking and signal transduction | Trends in Pharmacological Sciences | 2011 | 628 |
42 | The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases | Trends in Pharmacological Sciences | 2003 | 627 |
43 | Glucocorticoid receptor signaling in health and disease | Trends in Pharmacological Sciences | 2013 | 626 |
44 | Molecular diversity of voltage-dependent Ca2+ channels | Trends in Pharmacological Sciences | 1991 | 620 |
45 | The role of stress in drug self-administration | Trends in Pharmacological Sciences | 1998 | 620 |
46 | Agonist-receptor efficacy II: agonist trafficking of receptor signals | Trends in Pharmacological Sciences | 1995 | 619 |
47 | Mechanisms of Hedgehog pathway activation in cancer and implications for therapy | Trends in Pharmacological Sciences | 2009 | 615 |
48 | How does adenosine inhibit transmitter release? | Trends in Pharmacological Sciences | 1988 | 606 |
49 | Islet-activating protein, pertussis toxin: a probe for functions of the inhibitory guanine nucleotide regulatory component of adenylate cyclase | Trends in Pharmacological Sciences | 1984 | 603 |
50 | Cyclooxygenase 2: a molecular target for cancer prevention and treatment | Trends in Pharmacological Sciences | 2003 | 602 |