| # | Title | Journal | Year | Citations |
|---|
| 1 | Evaluation of Factors Related to Late Recurrence - Later than 10 Years after the Initial Treatment - in Primary Breast Cancer | Oncology | 2013 | 8,974 |
| 2 | Lynch Syndrome Patients with Limited Family History Identified in a Laboratory Setting: A Descriptive Study | Oncology | 2015 | 1,374 |
| 3 | VEGF as a Key Mediator of Angiogenesis in Cancer | Oncology | 2005 | 1,363 |
| 4 | Patients Tested at a Laboratory for Hereditary Cancer Syndromes Show an Overlap for Multiple Syndromes in Their Personal and Familial Cancer Histories | Oncology | 2015 | 1,101 |
| 5 | Altered Expression of miR-21, miR-31, miR-143 and miR-145 Is Related to Clinicopathologic Features of Colorectal Cancer | Oncology | 2007 | 619 |
| 6 | Neoplastic Characteristics of the DNA Found in the Plasma of Cancer Patients | Oncology | 1989 | 612 |
| 7 | Biology of HER2 and Its Importance in Breast Cancer | Oncology | 2001 | 551 |
| 8 | VEGF as a Therapeutic Target in Cancer | Oncology | 2005 | 513 |
| 9 | Results of a Nationwide Study on the Three-Field Lymph Node Dissection of Esophageal Cancer | Oncology | 1991 | 481 |
| 10 | Phase II Study of S-1, a Novel Oral Derivative of 5-Fluorouracil, in Advanced Gastric Cancer | Oncology | 2000 | 433 |
| 11 | The Baseline Ratio of Neutrophils to Lymphocytes Is Associated with Patient Prognosis in Advanced Gastric Cancer | Oncology | 2007 | 390 |
| 12 | EGFR Signaling and Drug Discovery | Oncology | 2009 | 387 |
| 13 | Expression of E-Cadherin, α-Catenin, β-Catenin and Plakoglobin in Esophageal Carcinomas and Its Prognostic Significance | Oncology | 1997 | 381 |
| 14 | Clinicopathological Study of Early Adenocarcinoma of the Gastric Cardia: Comparison with Early Adenocarcinoma of the Distal Stomach and Esophagus | Oncology | 2001 | 378 |
| 15 | Global Epidemiology of Head and Neck Cancers: A Continuing Challenge | Oncology | 2016 | 337 |
| 16 | Antitumor Activity of <i>β</i>-Carotene, Canthaxanthin and Phytoene | Oncology | 1982 | 328 |
| 17 | The Role of the IGF System in Cancer: From Basic to Clinical Studies and Clinical Applications | Oncology | 2002 | 315 |
| 18 | Adherence to Endocrine Therapy for Breast Cancer | Oncology | 2006 | 276 |
| 19 | Decreased Expression of MicroRNA-143 and -145 in Human Gastric Cancers | Oncology | 2009 | 266 |
| 20 | Managing Patients Treated with Bevacizumab Combination Therapy | Oncology | 2005 | 265 |
| 21 | A Review and Update on Cholangiocarcinoma | Oncology | 2004 | 237 |
| 22 | Gender Disparity of Hepatocellular Carcinoma: The Roles of Sex Hormones | Oncology | 2010 | 232 |
| 23 | The Intermediary Metabolism of the Prostate: A Key to Understanding the Pathogenesis and Progression of Prostate Malignancy | Oncology | 2000 | 231 |
| 24 | Clinicopathological and Prognostic Value of MicroRNA-21 and MicroRNA-155 in Colorectal Cancer | Oncology | 2010 | 223 |
| 25 | HER2 as a Prognostic Factor in Breast Cancer | Oncology | 2001 | 216 |
| 26 | Transarterial Chemoembolization Failure/Refractoriness: JSH-LCSGJ Criteria 2014 Update | Oncology | 2014 | 216 |
| 27 | Interleukin-6: A Masterplayer in the Cytokine Network | Oncology | 2020 | 215 |
| 28 | Cancer Invasion and Metastasis | Oncology | 2005 | 214 |
| 29 | Microwave Ablation of Hepatocellular Carcinoma | Oncology | 2007 | 212 |
| 30 | Metastatic Colorectal Cancer: From Improved Survival to Potential Cure | Oncology | 2010 | 210 |
| 31 | Phase III Trial of Satraplatin, an Oral Platinum plus Prednisone vs. Prednisone alone in Patients with Hormone-Refractory Prostate Cancer | Oncology | 2005 | 209 |
| 32 | Hepatocellular Carcinoma Associated with Hepatitis C Virus Infection in Japan: Projection to Other Countries in the Foreseeable Future | Oncology | 2002 | 206 |
| 33 | Combination of Bisphosphonates and Antiangiogenic Factors Induces Osteonecrosis of the Jaw More Frequently than Bisphosphonates Alone | Oncology | 2009 | 203 |
| 34 | Phase II Evaluation of Lyl56758 in Metastatic Breast Cancer | Oncology | 1988 | 193 |
| 35 | Elevated Plasma von Willebrand Factor Levels and Arterial Occlusive Complications Associated with Cisplatin-Based Chemotherapy | Oncology | 1985 | 191 |
| 36 | First-Line Herceptin® Monotherapy in Metastatic Breast Cancer | Oncology | 2001 | 184 |
| 37 | Biological Effects of 5-Azacytidine in Eukaryotes | Oncology | 1974 | 182 |
| 38 | C-myc and c-fos in Human Osteosarcoma: Prognostic Value of mRNA and Protein Expression | Oncology | 1998 | 182 |
| 39 | Herceptin® Alone or in Combination with Chemotherapy in the Treatment of HER2-Positive Metastatic Breast Cancer: Pivotal Trials | Oncology | 2001 | 181 |
| 40 | Immune Checkpoint Inhibition in Hepatocellular Carcinoma: Basics and Ongoing Clinical Trials | Oncology | 2017 | 180 |
| 41 | S100B Protein Detection in Serum Is a Significant Prognostic Factor in Metastatic Melanoma | Oncology | 1999 | 177 |
| 42 | Hand-Foot Syndrome (Hand-Foot Skin Reaction, Palmar-Plantar Erythrodysesthesia): Focus on Sorafenib and Sunitinib | Oncology | 2009 | 177 |
| 43 | Topotecan – A Novel Topoisomerase I Inhibitor: Pharmacology and Clinical Experience | Oncology | 1999 | 175 |
| 44 | Ifosfamide in the Adjuvant Therapy of Soft Tissue Sarcomas | Oncology | 2003 | 173 |
| 45 | Management of Hepatocellular Carcinoma in Japan: Consensus-Based Clinical Practice Manual Proposed by the Japan Society of Hepatology | Oncology | 2007 | 172 |
| 46 | Impact and Management of Skin Toxicity Associated with Anti-Epidermal Growth Factor Receptor Therapy: Survey Results | Oncology | 2007 | 171 |
| 47 | Radioprotectants: Current Status and New Directions | Oncology | 2002 | 168 |
| 48 | From Molecular Biology to Targeted Therapies for Hepatocellular Carcinoma: The Future Is Now | Oncology | 2007 | 167 |
| 49 | Computer-Aided Diagnosis Based on Convolutional Neural Network System for Colorectal Polyp Classification: Preliminary Experience | Oncology | 2017 | 167 |
| 50 | Nonsurgical Treatment of Hepatocellular Carcinoma: From Percutaneous Ethanol Injection Therapy and Percutaneous Microwave Coagulation Therapy to Radiofrequency Ablation | Oncology | 2002 | 166 |
