| # | Title | Journal | Year | Citations |
|---|
| 1 | UCSF ChimeraX: Structure visualization for researchers, educators, and developers | Protein Science | 2021 | 4,478 |
| 2 | How to measure and predict the molar absorption coefficient of a protein | Protein Science | 1995 | 3,742 |
| 3 | UCSF ChimeraX: Meeting modern challenges in visualization and analysis | Protein Science | 2018 | 3,377 |
| 4 | Verification of protein structures: Patterns of nonbonded atomic interactions | Protein Science | 1993 | 3,177 |
| 5 | MolProbity: More and better reference data for improved all‐atom structure validation | Protein Science | 2018 | 2,776 |
| 6 | Toward understanding the origin and evolution of cellular organisms | Protein Science | 2019 | 2,262 |
| 7 | Statistical potential for assessment and prediction of protein structures | Protein Science | 2006 | 2,104 |
| 8 | Thioflavine T interaction with synthetic Alzheimer's disease β‐amyloid peptides: Detection of amyloid aggregation in solution | Protein Science | 1993 | 2,007 |
| 9 | Modeling of loops in protein structures | Protein Science | 2000 | 1,895 |
| 10 | Denaturant m values and heat capacity changes: Relation to changes in accessible surface areas of protein unfolding | Protein Science | 1995 | 1,815 |
| 11 | ChloroP, a neural network‐based method for predicting chloroplast transit peptides and their cleavage sites | Protein Science | 1999 | 1,778 |
| 12 | Natively unfolded proteins: A point where biology waits for physics | Protein Science | 2002 | 1,650 |
| 13 | Improvements to the APBS biomolecular solvation software suite | Protein Science | 2018 | 1,399 |
| 14 | Genome‐wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms | Protein Science | 1998 | 1,329 |
| 15 | Principles of protein folding — A perspective from simple exact models | Protein Science | 1995 | 1,321 |
| 16 | Clustal Omega for making accurate alignments of many protein sequences | Protein Science | 2018 | 1,286 |
| 17 | Prediction of lipoprotein signal peptides in Gram-negative bacteria | Protein Science | 2003 | 1,016 |
| 18 | Reliable prediction of T-cell epitopes using neural networks with novel sequence representations | Protein Science | 2003 | 1,013 |
| 19 | PROMOTIF—A program to identify and analyze structural motifs in proteins | Protein Science | 1996 | 955 |
| 20 | Anatomy of protein pockets and cavities: Measurement of binding site geometry and implications for ligand design | Protein Science | 1998 | 949 |
| 21 | A revised set of potentials for β‐turn formation in proteins | Protein Science | 1994 | 918 |
| 22 | A graph-theory algorithm for rapid protein side-chain prediction | Protein Science | 2003 | 910 |
| 23 | PDBsum: Structural summaries of PDB entries | Protein Science | 2018 | 910 |
| 24 | Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation | Protein Science | 1993 | 908 |
| 25 | Escherichia coli maltose‐binding protein is uncommonly effective at promoting the solubility of polypeptides to which it is fused | Protein Science | 1999 | 880 |
| 26 | Distance-scaled, finite ideal-gas reference state improves structure-derived potentials of mean force for structure selection and stability prediction | Protein Science | 2009 | 836 |
| 27 | Subtilases: The superfamily of subtilisin-like serine proteases | Protein Science | 1997 | 797 |
| 28 | KEGG Mapper for inferring cellular functions from protein sequences | Protein Science | 2020 | 791 |
| 29 | The ankyrin repeat as molecular architecture for protein recognition | Protein Science | 2004 | 782 |
| 30 | The C2 domain calcium‐binding motif: Structural and functional diversity | Protein Science | 1996 | 770 |
| 31 | The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions | Protein Science | 2021 | 769 |
| 32 | Predicting subcellular localization of proteins for Gram-negative bacteria by support vector machines based onn-peptide compositions | Protein Science | 2004 | 768 |
| 33 | Selection of representative protein data sets | Protein Science | 1992 | 748 |
| 34 | 3D domain swapping: A mechanism for oligomer assembly | Protein Science | 1995 | 742 |
| 35 | Bayesian statistical analysis of protein side‐chain rotamer preferences | Protein Science | 1997 | 727 |
| 36 | Structural basis of substrate specificity in the serine proteases | Protein Science | 1995 | 726 |
| 37 | Enlarged representative set of protein structures | Protein Science | 1994 | 693 |
| 38 | Helix capping | Protein Science | 1998 | 674 |
| 39 | Matthews coefficient probabilities: Improved estimates for unit cell contents of proteins, DNA, and protein-nucleic acid complex crystals | Protein Science | 2003 | 672 |
| 40 | MultiCoil: A program for predicting two‐and three‐stranded coiled coils | Protein Science | 1997 | 667 |
| 41 | The human protein atlas: A spatial map of the human proteome | Protein Science | 2018 | 667 |
| 42 | 3D domain swapping: As domains continue to swap | Protein Science | 2002 | 648 |
| 43 | Sensitivity of secondary structure propensities to sequence differences between α- and γ-synuclein: Implications for fibrillation | Protein Science | 2006 | 648 |
| 44 | Can correct protein models be identified? | Protein Science | 2003 | 646 |
| 45 | Modern analytical ultracentrifugation in protein science: A tutorial review | Protein Science | 2009 | 642 |
| 46 | Effect of trehalose on protein structure | Protein Science | 2009 | 640 |
| 47 | A minimal peptide substrate in biotin holoenzyme synthetase‐catalyzed biotinylation | Protein Science | 1999 | 640 |
| 48 | Estimation of the number of α‐helical and β‐strand segments in proteins using circular dichroism spectroscopy | Protein Science | 1999 | 637 |
| 49 | Folding funnels, binding funnels, and protein function | Protein Science | 1999 | 634 |
| 50 | Transmembrane helices predicted at 95% accuracy | Protein Science | 1995 | 628 |
