# | Title | Journal | Year | Citations |
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1 | A simplified method of evaluating dose-effect experiments | Journal of Pharmacology and Experimental Therapeutics | 1949 | 4,135 |
2 | The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog | Journal of Pharmacology and Experimental Therapeutics | 1976 | 2,094 |
3 | Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians | Journal of Pharmacology and Experimental Therapeutics | 1994 | 1,873 |
4 | A method for the fluorometric assay of histamine in tissues | Journal of Pharmacology and Experimental Therapeutics | 1959 | 1,654 |
5 | A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines | Journal of Pharmacology and Experimental Therapeutics | 1962 | 1,467 |
6 | Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates | Journal of Pharmacology and Experimental Therapeutics | 1981 | 1,243 |
7 | Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines | Journal of Pharmacology and Experimental Therapeutics | 1953 | 1,147 |
8 | Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione | Journal of Pharmacology and Experimental Therapeutics | 1973 | 1,136 |
9 | p-Chlorophenylalanine: a specific depletor of brain serotonin | Journal of Pharmacology and Experimental Therapeutics | 1966 | 1,085 |
10 | Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic Intervention | Journal of Pharmacology and Experimental Therapeutics | 2003 | 1,019 |
11 | Functional Selectivity and Classical Concepts of Quantitative Pharmacology | Journal of Pharmacology and Experimental Therapeutics | 2007 | 997 |
12 | Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta | Journal of Pharmacology and Experimental Therapeutics | 1985 | 959 |
13 | Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism | Journal of Pharmacology and Experimental Therapeutics | 1973 | 949 |
14 | The Cholinergic Hypothesis of Age and Alzheimer's Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development | Journal of Pharmacology and Experimental Therapeutics | 2003 | 940 |
15 | Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors | Journal of Pharmacology and Experimental Therapeutics | 2000 | 926 |
16 | Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values | Journal of Pharmacology and Experimental Therapeutics | 1989 | 862 |
17 | Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity | Journal of Pharmacology and Experimental Therapeutics | 1973 | 858 |
18 | Aripiprazole, a Novel Antipsychotic, Is a High-Affinity Partial Agonist at Human Dopamine D2 Receptors | Journal of Pharmacology and Experimental Therapeutics | 2002 | 856 |
19 | Role of Tyrosine Kinase Inhibitors in Cancer Therapy | Journal of Pharmacology and Experimental Therapeutics | 2005 | 846 |
20 | Oxidative Stress and the Central Nervous System | Journal of Pharmacology and Experimental Therapeutics | 2017 | 783 |
21 | Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo | Journal of Pharmacology and Experimental Therapeutics | 1973 | 782 |
22 | Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic | Journal of Pharmacology and Experimental Therapeutics | 1992 | 746 |
23 | Production and Actions of Hydrogen Sulfide, a Novel Gaseous Bioactive Substance, in the Kidneys | Journal of Pharmacology and Experimental Therapeutics | 2009 | 736 |
24 | Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker | Journal of Pharmacology and Experimental Therapeutics | 2012 | 734 |
25 | Inhibition of Microglial Activation Attenuates the Development but Not Existing Hypersensitivity in a Rat Model of Neuropathy | Journal of Pharmacology and Experimental Therapeutics | 2003 | 733 |
26 | Novel Antiangiogenic Effects of the Bisphosphonate Compound Zoledronic Acid | Journal of Pharmacology and Experimental Therapeutics | 2002 | 729 |
27 | Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats | Journal of Pharmacology and Experimental Therapeutics | 1988 | 711 |
28 | A New Benzodiazepine Pharmacology | Journal of Pharmacology and Experimental Therapeutics | 2002 | 684 |
29 | Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol | Journal of Pharmacology and Experimental Therapeutics | 1986 | 674 |
30 | SCH 23390, a potential benzazepine antipsychotic with unique interactions on dopaminergic systems | Journal of Pharmacology and Experimental Therapeutics | 1983 | 674 |
31 | The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data | Journal of Pharmacology and Experimental Therapeutics | 1997 | 658 |
32 | ELUCIDATION OF THE RATE-LIMITING STEP IN NOREPINEPHRINE BIOSYNTHESIS IN THE PERFUSED GUINEA-PIG HEART | Journal of Pharmacology and Experimental Therapeutics | 1965 | 644 |
33 | Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates | Journal of Pharmacology and Experimental Therapeutics | 2001 | 637 |
34 | A Novel, Potent, and Selective Inhibitor of Cardiac Late Sodium Current Suppresses Experimental Arrhythmias | Journal of Pharmacology and Experimental Therapeutics | 2013 | 631 |
35 | A simple, sensitive method for the assay of adenyl cyclase | Journal of Pharmacology and Experimental Therapeutics | 1968 | 614 |
36 | Binding and Functional Comparisons of Two Types of Tumor Necrosis Factor Antagonists | Journal of Pharmacology and Experimental Therapeutics | 2002 | 610 |
37 | U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist | Journal of Pharmacology and Experimental Therapeutics | 1983 | 600 |
38 | Extent and Direction of Ghrelin Transport Across the Blood-Brain Barrier Is Determined by Its Unique Primary Structure | Journal of Pharmacology and Experimental Therapeutics | 2002 | 592 |
39 | Comprehensive Evaluation of Tamoxifen Sequential Biotransformation by the Human Cytochrome P450 System in Vitro: Prominent Roles for CYP3A and CYP2D6 | Journal of Pharmacology and Experimental Therapeutics | 2004 | 579 |
40 | Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs | Journal of Pharmacology and Experimental Therapeutics | 2002 | 567 |
41 | Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants | Journal of Pharmacology and Experimental Therapeutics | 1993 | 562 |
42 | The Cytochrome P450 2B6 (CYP2B6) Is the Main Catalyst of Efavirenz Primary and Secondary Metabolism: Implication for HIV/AIDS Therapy and Utility of Efavirenz as a Substrate Marker of CYP2B6 Catalytic Activity | Journal of Pharmacology and Experimental Therapeutics | 2003 | 560 |
43 | Mitochondrial Dysfunction in Neurodegenerative Diseases | Journal of Pharmacology and Experimental Therapeutics | 2012 | 557 |
44 | Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer's Disease | Journal of Pharmacology and Experimental Therapeutics | 2008 | 548 |
45 | Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism | Journal of Pharmacology and Experimental Therapeutics | 1997 | 546 |
46 | Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system | Journal of Pharmacology and Experimental Therapeutics | 2001 | 534 |
47 | Morphine Side Effects in β-Arrestin 2 Knockout Mice | Journal of Pharmacology and Experimental Therapeutics | 2005 | 532 |
48 | Characterization of a Novel Endocannabinoid, Virodhamine, with Antagonist Activity at the CB1 Receptor | Journal of Pharmacology and Experimental Therapeutics | 2002 | 531 |
49 | A G Protein-Biased Ligand at theμ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine | Journal of Pharmacology and Experimental Therapeutics | 2013 | 512 |
50 | Histone Deacetylase Inhibitors Exhibit Anti-Inflammatory and Neuroprotective Effects in a Rat Permanent Ischemic Model of Stroke: Multiple Mechanisms of Action | Journal of Pharmacology and Experimental Therapeutics | 2007 | 511 |