3.2(top 10%)
impact factor
29.6K(top 1%)
papers
1.1M(top 1%)
citations
267(top 1%)
h-index
3.3(top 10%)
impact factor
30.1K
all documents
1.1M
doc citations
383(top 1%)
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Top Articles

#TitleJournalYearCitations
1A simplified method of evaluating dose-effect experimentsJournal of Pharmacology and Experimental Therapeutics19494,135
2The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dogJournal of Pharmacology and Experimental Therapeutics19762,094
3Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 CaucasiansJournal of Pharmacology and Experimental Therapeutics19941,873
4A method for the fluorometric assay of histamine in tissuesJournal of Pharmacology and Experimental Therapeutics19591,654
5A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholaminesJournal of Pharmacology and Experimental Therapeutics19621,467
6Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediatesJournal of Pharmacology and Experimental Therapeutics19811,243
7Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylaminesJournal of Pharmacology and Experimental Therapeutics19531,147
8Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathioneJournal of Pharmacology and Experimental Therapeutics19731,136
9p-Chlorophenylalanine: a specific depletor of brain serotoninJournal of Pharmacology and Experimental Therapeutics19661,085
10Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic InterventionJournal of Pharmacology and Experimental Therapeutics20031,019
11Functional Selectivity and Classical Concepts of Quantitative PharmacologyJournal of Pharmacology and Experimental Therapeutics2007997
12Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aortaJournal of Pharmacology and Experimental Therapeutics1985959
13Acetaminophen-induced hepatic necrosis. I. Role of drug metabolismJournal of Pharmacology and Experimental Therapeutics1973949
14The Cholinergic Hypothesis of Age and Alzheimer's Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug DevelopmentJournal of Pharmacology and Experimental Therapeutics2003940
15Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptorsJournal of Pharmacology and Experimental Therapeutics2000926
16Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi valuesJournal of Pharmacology and Experimental Therapeutics1989862
17Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activityJournal of Pharmacology and Experimental Therapeutics1973858
18Aripiprazole, a Novel Antipsychotic, Is a High-Affinity Partial Agonist at Human Dopamine D2 ReceptorsJournal of Pharmacology and Experimental Therapeutics2002856
19Role of Tyrosine Kinase Inhibitors in Cancer TherapyJournal of Pharmacology and Experimental Therapeutics2005846
20Oxidative Stress and the Central Nervous SystemJournal of Pharmacology and Experimental Therapeutics2017783
21Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivoJournal of Pharmacology and Experimental Therapeutics1973782
22Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesicJournal of Pharmacology and Experimental Therapeutics1992746
23Production and Actions of Hydrogen Sulfide, a Novel Gaseous Bioactive Substance, in the KidneysJournal of Pharmacology and Experimental Therapeutics2009736
24Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family BlockerJournal of Pharmacology and Experimental Therapeutics2012734
25Inhibition of Microglial Activation Attenuates the Development but Not Existing Hypersensitivity in a Rat Model of NeuropathyJournal of Pharmacology and Experimental Therapeutics2003733
26Novel Antiangiogenic Effects of the Bisphosphonate Compound Zoledronic AcidJournal of Pharmacology and Experimental Therapeutics2002729
27Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving ratsJournal of Pharmacology and Experimental Therapeutics1988711
28A New Benzodiazepine PharmacologyJournal of Pharmacology and Experimental Therapeutics2002684
29Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanolJournal of Pharmacology and Experimental Therapeutics1986674
30SCH 23390, a potential benzazepine antipsychotic with unique interactions on dopaminergic systemsJournal of Pharmacology and Experimental Therapeutics1983674
31The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism dataJournal of Pharmacology and Experimental Therapeutics1997658
32ELUCIDATION OF THE RATE-LIMITING STEP IN NOREPINEPHRINE BIOSYNTHESIS IN THE PERFUSED GUINEA-PIG HEARTJournal of Pharmacology and Experimental Therapeutics1965644
33Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonatesJournal of Pharmacology and Experimental Therapeutics2001637
34A Novel, Potent, and Selective Inhibitor of Cardiac Late Sodium Current Suppresses Experimental ArrhythmiasJournal of Pharmacology and Experimental Therapeutics2013631
35A simple, sensitive method for the assay of adenyl cyclaseJournal of Pharmacology and Experimental Therapeutics1968614
36Binding and Functional Comparisons of Two Types of Tumor Necrosis Factor AntagonistsJournal of Pharmacology and Experimental Therapeutics2002610
37U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonistJournal of Pharmacology and Experimental Therapeutics1983600
38Extent and Direction of Ghrelin Transport Across the Blood-Brain Barrier Is Determined by Its Unique Primary StructureJournal of Pharmacology and Experimental Therapeutics2002592
39Comprehensive Evaluation of Tamoxifen Sequential Biotransformation by the Human Cytochrome P450 System in Vitro: Prominent Roles for CYP3A and CYP2D6Journal of Pharmacology and Experimental Therapeutics2004579
40Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed DrugsJournal of Pharmacology and Experimental Therapeutics2002567
41Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinantsJournal of Pharmacology and Experimental Therapeutics1993562
42The Cytochrome P450 2B6 (CYP2B6) Is the Main Catalyst of Efavirenz Primary and Secondary Metabolism: Implication for HIV/AIDS Therapy and Utility of Efavirenz as a Substrate Marker of CYP2B6 Catalytic ActivityJournal of Pharmacology and Experimental Therapeutics2003560
43Mitochondrial Dysfunction in Neurodegenerative DiseasesJournal of Pharmacology and Experimental Therapeutics2012557
44Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer's DiseaseJournal of Pharmacology and Experimental Therapeutics2008548
45Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolismJournal of Pharmacology and Experimental Therapeutics1997546
46Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous systemJournal of Pharmacology and Experimental Therapeutics2001534
47Morphine Side Effects in β-Arrestin 2 Knockout MiceJournal of Pharmacology and Experimental Therapeutics2005532
48Characterization of a Novel Endocannabinoid, Virodhamine, with Antagonist Activity at the CB1 ReceptorJournal of Pharmacology and Experimental Therapeutics2002531
49A G Protein-Biased Ligand at theμ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with MorphineJournal of Pharmacology and Experimental Therapeutics2013512
50Histone Deacetylase Inhibitors Exhibit Anti-Inflammatory and Neuroprotective Effects in a Rat Permanent Ischemic Model of Stroke: Multiple Mechanisms of ActionJournal of Pharmacology and Experimental Therapeutics2007511