| # | Title | Journal | Year | Citations |
|---|
| 1 | A plant-wide industrial process control problem | Computers and Chemical Engineering | 1993 | 2,499 |
| 2 | A review of process fault detection and diagnosis | Computers and Chemical Engineering | 2003 | 1,972 |
| 3 | Model predictive control: past, present and future | Computers and Chemical Engineering | 1999 | 1,726 |
| 4 | A review of process fault detection and diagnosis | Computers and Chemical Engineering | 2003 | 1,445 |
| 5 | Data-driven Soft Sensors in the process industry | Computers and Chemical Engineering | 2009 | 1,342 |
| 6 | A review of process fault detection and diagnosis | Computers and Chemical Engineering | 2003 | 1,243 |
| 7 | A general algorithm for short-term scheduling of batch operations—I. MILP formulation | Computers and Chemical Engineering | 1993 | 1,004 |
| 8 | Simultaneous optimization models for heat integration—II. Heat exchanger network synthesis | Computers and Chemical Engineering | 1990 | 895 |
| 9 | Optimization under uncertainty: state-of-the-art and opportunities | Computers and Chemical Engineering | 2004 | 893 |
| 10 | Distributed model predictive control: A tutorial review and future research directions | Computers and Chemical Engineering | 2013 | 697 |
| 11 | State-of-the-art review of optimization methods for short-term scheduling of batch processes | Computers and Chemical Engineering | 2006 | 675 |
| 12 | A combined penalty function and outer-approximation method for MINLP optimization | Computers and Chemical Engineering | 1990 | 622 |
| 13 | A structural optimization approach in process synthesis—II | Computers and Chemical Engineering | 1983 | 615 |
| 14 | Use of neural nets for dynamic modeling and control of chemical process systems | Computers and Chemical Engineering | 1990 | 589 |
| 15 | Biomass-to-bioenergy and biofuel supply chain optimization: Overview, key issues and challenges | Computers and Chemical Engineering | 2014 | 563 |
| 16 | Nonlinear principal component analysis—Based on principal curves and neural networks | Computers and Chemical Engineering | 1996 | 558 |
| 17 | Continuous-time versus discrete-time approaches for scheduling of chemical processes: a review | Computers and Chemical Engineering | 2004 | 555 |
| 18 | Smart manufacturing, manufacturing intelligence and demand-dynamic performance | Computers and Chemical Engineering | 2012 | 555 |
| 19 | Recursive PLS algorithms for adaptive data modeling | Computers and Chemical Engineering | 1998 | 524 |
| 20 | A modular simulation package for fed-batch fermentation: penicillin production | Computers and Chemical Engineering | 2002 | 512 |
| 21 | An overview of subspace identification | Computers and Chemical Engineering | 2006 | 482 |
| 22 | Retrospective on optimization | Computers and Chemical Engineering | 2004 | 475 |
| 23 | Fault diagnosis based on Fisher discriminant analysis and support vector machines | Computers and Chemical Engineering | 2004 | 458 |
| 24 | Plant-wide control of the Tennessee Eastman problem | Computers and Chemical Engineering | 1995 | 454 |
| 25 | A global optimization method, αBB, for general twice-differentiable constrained NLPs — I. Theoretical advances | Computers and Chemical Engineering | 1998 | 454 |
| 26 | New insights in solving distributed system equations by the quadrature method—I. Analysis | Computers and Chemical Engineering | 1989 | 451 |
| 27 | Nonlinear model predictive control: current status and future directions | Computers and Chemical Engineering | 1998 | 437 |
| 28 | Advances in surrogate based modeling, feasibility analysis, and optimization: A review | Computers and Chemical Engineering | 2018 | 437 |
| 29 | Modelling and computational techniques for logic based integer programming | Computers and Chemical Engineering | 1994 | 435 |
| 30 | Data-based process monitoring, process control, and quality improvement: Recent developments and applications in steel industry | Computers and Chemical Engineering | 2008 | 429 |
| 31 | Managing demand uncertainty in supply chain planning | Computers and Chemical Engineering | 2003 | 423 |
| 32 | Large-scale nonlinear programming using IPOPT: An integrating framework for enterprise-wide dynamic optimization | Computers and Chemical Engineering | 2009 | 417 |
| 33 | Scope for industrial applications of production scheduling models and solution methods | Computers and Chemical Engineering | 2014 | 411 |
| 34 | Review of adaptation mechanisms for data-driven soft sensors | Computers and Chemical Engineering | 2011 | 402 |
| 35 | Nonlinear PLS modeling using neural networks | Computers and Chemical Engineering | 1992 | 383 |
| 36 | Autoassociative neural networks | Computers and Chemical Engineering | 1992 | 372 |
| 37 | Artificial neural network models of knowledge representation in chemical engineering | Computers and Chemical Engineering | 1988 | 364 |
| 38 | Sensitivity analysis of initial value problems with mixed odes and algebraic equations | Computers and Chemical Engineering | 1985 | 362 |
| 39 | Dynamic optimization of batch processes | Computers and Chemical Engineering | 2003 | 359 |
| 40 | Global optimization for the synthesis of integrated water systems in chemical processes | Computers and Chemical Engineering | 2006 | 357 |
| 41 | Active constraint strategy for flexibility analysis in chemical processes | Computers and Chemical Engineering | 1987 | 352 |
| 42 | Generic model control (GMC) | Computers and Chemical Engineering | 1988 | 350 |
| 43 | Control structure design for complete chemical plants | Computers and Chemical Engineering | 2004 | 349 |
| 44 | Global optimization of nonconvex NLPs and MINLPs with applications in process design | Computers and Chemical Engineering | 1995 | 344 |
| 45 | The kinetic preprocessor KPP-a software environment for solving chemical kinetics | Computers and Chemical Engineering | 2002 | 343 |
| 46 | A review of recent design procedures for water networks in refineries and process plants | Computers and Chemical Engineering | 2000 | 336 |
| 47 | On-line outlier detection and data cleaning | Computers and Chemical Engineering | 2004 | 335 |
| 48 | Deep convolutional neural network model based chemical process fault diagnosis | Computers and Chemical Engineering | 2018 | 330 |
| 49 | Solution of dynamic optimization problems by successive quadratic programming and orthogonal collocation | Computers and Chemical Engineering | 1984 | 327 |
| 50 | Pharmaceutical supply chains: key issues and strategies for optimisation | Computers and Chemical Engineering | 2004 | 325 |
