| # | Title | Journal | Year | Citations |
|---|
| 1 | Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities | Molecular Cell | 2010 | 10,215 |
| 2 | The Inflammasome | Molecular Cell | 2002 | 5,010 |
| 3 | Molecular Mechanisms of Long Noncoding RNAs | Molecular Cell | 2011 | 3,833 |
| 4 | The DNA Damage Response: Making It Safe to Play with Knives | Molecular Cell | 2010 | 3,563 |
| 5 | MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing | Molecular Cell | 2007 | 3,386 |
| 6 | AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint | Molecular Cell | 2008 | 3,147 |
| 7 | Autophagy and the Integrated Stress Response | Molecular Cell | 2010 | 2,982 |
| 8 | An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress | Molecular Cell | 2003 | 2,791 |
| 9 | Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells | Molecular Cell | 2000 | 2,743 |
| 10 | Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates | Molecular Cell | 2013 | 2,734 |
| 11 | Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway | Molecular Cell | 2008 | 2,614 |
| 12 | ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility | Molecular Cell | 2013 | 2,549 |
| 13 | circRNA Biogenesis Competes with Pre-mRNA Splicing | Molecular Cell | 2014 | 2,490 |
| 14 | Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB | Molecular Cell | 2006 | 2,388 |
| 15 | Computational Identification of Plant MicroRNAs and Their Targets, Including a Stress-Induced miRNA | Molecular Cell | 2004 | 2,097 |
| 16 | Physiological Roles of Mitochondrial Reactive Oxygen Species | Molecular Cell | 2012 | 2,067 |
| 17 | PUMA, a Novel Proapoptotic Gene, Is Induced by p53 | Molecular Cell | 2001 | 2,023 |
| 18 | Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed | Molecular Cell | 2015 | 1,974 |
| 19 | FLS2 | Molecular Cell | 2000 | 1,968 |
| 20 | p63, a p53 Homolog at 3q27–29, Encodes Multiple Products with Transactivating, Death-Inducing, and Dominant-Negative Activities | Molecular Cell | 1998 | 1,943 |
| 21 | Hypoxia-Inducible Factors and the Response to Hypoxic Stress | Molecular Cell | 2010 | 1,930 |
| 22 | A Genome-Wide Transcriptional Analysis of the Mitotic Cell Cycle | Molecular Cell | 1998 | 1,927 |
| 23 | The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation | Molecular Cell | 2010 | 1,906 |
| 24 | Circular Intronic Long Noncoding RNAs | Molecular Cell | 2013 | 1,858 |
| 25 | Transactivation of miR-34a by p53 Broadly Influences Gene Expression and Promotes Apoptosis | Molecular Cell | 2007 | 1,844 |
| 26 | PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro | Molecular Cell | 1999 | 1,804 |
| 27 | PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development | Molecular Cell | 1999 | 1,780 |
| 28 | Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response | Molecular Cell | 2000 | 1,746 |
| 29 | Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs | Molecular Cell | 2004 | 1,699 |
| 30 | Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control | Molecular Cell | 2002 | 1,685 |
| 31 | Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis | Molecular Cell | 2017 | 1,672 |
| 32 | VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling | Molecular Cell | 2005 | 1,656 |
| 33 | Positionally Cloned Gene for a Novel Glomerular Protein—Nephrin—Is Mutated in Congenital Nephrotic Syndrome | Molecular Cell | 1998 | 1,654 |
| 34 | The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors | Molecular Cell | 2004 | 1,647 |
| 35 | A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis | Molecular Cell | 2000 | 1,646 |
| 36 | Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function | Molecular Cell | 2005 | 1,639 |
| 37 | The Heat Shock Response: Life on the Verge of Death | Molecular Cell | 2010 | 1,603 |
| 38 | p53 Has a Direct Apoptogenic Role at the Mitochondria | Molecular Cell | 2003 | 1,599 |
| 39 | Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1 | Molecular Cell | 2010 | 1,598 |
| 40 | ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs | Molecular Cell | 2000 | 1,588 |
| 41 | BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis | Molecular Cell | 2001 | 1,535 |
| 42 | A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells | Molecular Cell | 2020 | 1,527 |
| 43 | Mechanisms of Caspase Activation and Inhibition during Apoptosis | Molecular Cell | 2002 | 1,520 |
| 44 | The Biogenesis, Functions, and Challenges of Circular RNAs | Molecular Cell | 2018 | 1,511 |
| 45 | The DNA Damage Response: Ten Years After | Molecular Cell | 2007 | 1,494 |
| 46 | Protein Arginine Methylation in Mammals: Who, What, and Why | Molecular Cell | 2009 | 1,487 |
| 47 | Localization of ASH1 mRNA Particles in Living Yeast | Molecular Cell | 1998 | 1,475 |
| 48 | SUMO | Molecular Cell | 2005 | 1,468 |
| 49 | Absence of Monocyte Chemoattractant Protein-1 Reduces Atherosclerosis in Low Density Lipoprotein Receptor–Deficient Mice | Molecular Cell | 1998 | 1,449 |
| 50 | Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing | Molecular Cell | 2016 | 1,432 |
