| # | Title | Journal | Year | Citations |
|---|
| 1 | A global clinical measure of fitness and frailty in elderly people | Cmaj | 2005 | 5,720 |
| 2 | Health benefits of physical activity: the evidence | Cmaj | 2006 | 5,315 |
| 3 | AGREE II: advancing guideline development, reporting and evaluation in health care | Cmaj | 2010 | 2,389 |
| 4 | The Canadian Adverse Events Study: the incidence of adverse events among hospital patients in Canada | Cmaj | 2004 | 1,729 |
| 5 | Optimal cut-off score for diagnosing depression with the Patient Health Questionnaire (PHQ-9): a meta-analysis | Cmaj | 2012 | 1,336 |
| 6 | Liver enzyme alteration: a guide for clinicians | Cmaj | 2005 | 1,300 |
| 7 | 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary | Cmaj | 2010 | 1,143 |
| 8 | Effective physician-patient communication and health outcomes: a review | Cmaj | 1995 | 996 |
| 9 | Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity | Cmaj | 2004 | 988 |
| 10 | A guide for the design and conduct of self-administered surveys of clinicians | Cmaj | 2008 | 947 |
| 11 | Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data | Cmaj | 2009 | 927 |
| 12 | Common mental health problems in immigrants and refugees: general approach in primary care | Cmaj | 2011 | 897 |
| 13 | Effects of exercise on breast cancer patients and survivors: a systematic review and meta-analysis | Cmaj | 2006 | 883 |
| 14 | 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary] | Cmaj | 2007 | 878 |
| 15 | The appropriateness of asymmetry tests for publication bias in meta-analyses: a large survey | Cmaj | 2007 | 833 |
| 16 | Malnutrition and health in developing countries | Cmaj | 2005 | 757 |
| 17 | Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months | Cmaj | 2013 | 741 |
| 18 | Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects | Cmaj | 2006 | 735 |
| 19 | Family caregiver burden: results of a longitudinal study of breast cancer patients and their principal caregivers | Cmaj | 2004 | 726 |
| 20 | Derivation and validation of an index to predict early death or unplanned readmission after discharge from hospital to the community | Cmaj | 2010 | 726 |
| 21 | Inequalities in access to medical care by income in developed countries | Cmaj | 2006 | 714 |
| 22 | Fetal alcohol spectrum disorder: Canadian guidelines for diagnosis | Cmaj | 2005 | 701 |
| 23 | Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis | Cmaj | 2010 | 674 |
| 24 | Defining knowledge translation | Cmaj | 2009 | 663 |
| 25 | Maternal mortality and severe morbidity associated with low-risk planned cesarean delivery versus planned vaginal delivery at term | Cmaj | 2007 | 653 |
| 26 | Frequency, type and clinical importance of medication history errors at admission to hospital: a systematic review | Cmaj | 2005 | 638 |
| 27 | A population-based study of the drug interaction between proton pump inhibitors and clopidogrel | Cmaj | 2009 | 622 |
| 28 | The immediate psychological and occupational impact of the 2003 SARS outbreak in a teaching hospital | Cmaj | 2003 | 607 |
| 29 | Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis | Cmaj | 2008 | 605 |
| 30 | Obesity in adults: a clinical practice guideline | Cmaj | 2020 | 592 |
| 31 | Psychosocial effects of SARS on hospital staff: survey of a large tertiary care institution | Cmaj | 2004 | 577 |
| 32 | Proportion of hospital readmissions deemed avoidable: a systematic review | Cmaj | 2011 | 556 |
| 33 | What matters most in end-of-life care: perceptions of seriously ill patients and their family members | Cmaj | 2006 | 552 |
| 34 | Perioperative cardiac events in patients undergoing noncardiac surgery: a review of the magnitude of the problem, the pathophysiology of the events and methods to estimate and communicate risk | Cmaj | 2005 | 543 |
| 35 | Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec | Cmaj | 2005 | 536 |
| 36 | Nonalcoholic fatty liver disease | Cmaj | 2005 | 512 |
| 37 | Troponin: the biomarker of choice for the detection of cardiac injury | Cmaj | 2005 | 509 |
| 38 | Guideline for opioid therapy and chronic noncancer pain | Cmaj | 2017 | 506 |
| 39 | Risk of Clostridium difficile diarrhea among hospital inpatients prescribed proton pump inhibitors: cohort and case-control studies | Cmaj | 2004 | 499 |
| 40 | Evidence of bias and variation in diagnostic accuracy studies | Cmaj | 2006 | 489 |
| 41 | Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy | Cmaj | 2008 | 484 |
| 42 | No magic bullets: a systematic review of 102 trials of interventions to improve professional practice | Cmaj | 1995 | 482 |
| 43 | The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis | Cmaj | 2021 | 478 |
| 44 | Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis | Cmaj | 2009 | 463 |
| 45 | Integration of evidence from multiple meta-analyses: a primer on umbrella reviews, treatment networks and multiple treatments meta-analyses | Cmaj | 2009 | 454 |
| 46 | Hypertriglyceridemia: its etiology, effects and treatment | Cmaj | 2007 | 443 |
| 47 | The effects of problem-based learning during medical school on physician competency: a systematic review | Cmaj | 2008 | 443 |
| 48 | The prognosis of acute and persistent low-back pain: a meta-analysis | Cmaj | 2012 | 441 |
| 49 | Guidelines 2.0: systematic development of a comprehensive checklist for a successful guideline enterprise | Cmaj | 2014 | 441 |
| 50 | Vitamin B12 (cobalamin) deficiency in elderly patients | Cmaj | 2004 | 434 |
