| # | Title | Journal | Year | Citations |
|---|
| 1 | The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD) | Metabolism: Clinical and Experimental | 2016 | 1,977 |
| 2 | The epidemiology of obesity | Metabolism: Clinical and Experimental | 2019 | 1,603 |
| 3 | The theoretical bases of indirect calorimetry: A review | Metabolism: Clinical and Experimental | 1988 | 1,425 |
| 4 | Artificial intelligence in medicine | Metabolism: Clinical and Experimental | 2017 | 1,185 |
| 5 | Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity | Metabolism: Clinical and Experimental | 1987 | 1,173 |
| 6 | What is oxidative stress? | Metabolism: Clinical and Experimental | 2000 | 1,133 |
| 7 | Starch-gel electrophoresis—Application to the classification of pituitary proteins and polypeptides | Metabolism: Clinical and Experimental | 1964 | 1,022 |
| 8 | Serum cholesterol response to changes in the diet | Metabolism: Clinical and Experimental | 1965 | 894 |
| 9 | Obesity and cancer risk: Emerging biological mechanisms and perspectives | Metabolism: Clinical and Experimental | 2019 | 821 |
| 10 | FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise | Metabolism: Clinical and Experimental | 2012 | 812 |
| 11 | Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy | Metabolism: Clinical and Experimental | 1994 | 788 |
| 12 | Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men | Metabolism: Clinical and Experimental | 1997 | 751 |
| 13 | Insulin resistance, insulin insensitivity, and insulin unresponsiveness: A necessary distinction | Metabolism: Clinical and Experimental | 1978 | 746 |
| 14 | Serum cholesterol response to changes in the diet | Metabolism: Clinical and Experimental | 1965 | 745 |
| 15 | The glucose-alanine cycle | Metabolism: Clinical and Experimental | 1973 | 720 |
| 16 | Severe obesity, increasing age and male sex are independently associated with worse in-hospital outcomes, and higher in-hospital mortality, in a cohort of patients with COVID-19 in the Bronx, New York | Metabolism: Clinical and Experimental | 2020 | 682 |
| 17 | Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics | Metabolism: Clinical and Experimental | 2019 | 679 |
| 18 | Adult lean body mass declines with age: Some longitudinal observations | Metabolism: Clinical and Experimental | 1970 | 674 |
| 19 | A new rat model of type 2 diabetes: The fat-fed, streptozotocin-treated rat | Metabolism: Clinical and Experimental | 2000 | 666 |
| 20 | Glucocorticoids, depression, and mood disorders: structural remodeling in the brain | Metabolism: Clinical and Experimental | 2005 | 611 |
| 21 | Efficacy of berberine in patients with type 2 diabetes mellitus | Metabolism: Clinical and Experimental | 2008 | 594 |
| 22 | Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and mice | Metabolism: Clinical and Experimental | 1995 | 579 |
| 23 | Validation of a screening questionnaire for androgen deficiency in aging males | Metabolism: Clinical and Experimental | 2000 | 570 |
| 24 | Use of a heated superficial hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man | Metabolism: Clinical and Experimental | 1981 | 562 |
| 25 | Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels | Metabolism: Clinical and Experimental | 1990 | 544 |
| 26 | Sleep deprivation as a neurobiologic and physiologic stressor: allostasis and allostatic load | Metabolism: Clinical and Experimental | 2006 | 507 |
| 27 | Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity | Metabolism: Clinical and Experimental | 2001 | 496 |
| 28 | Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: Contributions of excessive hepatic glucose production and impaired tissue glucose uptake | Metabolism: Clinical and Experimental | 1989 | 492 |
| 29 | Insulin resistance is a characteristic feature of primary hypertension independent of obesity | Metabolism: Clinical and Experimental | 1990 | 489 |
| 30 | Effect of prolonged bed rest on bone mineral | Metabolism: Clinical and Experimental | 1970 | 481 |
| 31 | The pharmacology of dichloroacetate | Metabolism: Clinical and Experimental | 1989 | 474 |
| 32 | Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism | Metabolism: Clinical and Experimental | 2015 | 473 |
| 33 | Labile methyl balances for normal humans on various dietary regimens | Metabolism: Clinical and Experimental | 1975 | 472 |
| 34 | Serum cholesterol response to changes in the diet | Metabolism: Clinical and Experimental | 1965 | 470 |
| 35 | The effect of aging on carbohydrate metabolism: A review of the English literature and a practical approach to the diagnosis of diabetes mellitus in the elderly | Metabolism: Clinical and Experimental | 1979 | 459 |
| 36 | Adolescent overweight is associated with adult overweight and related multiple cardiovascular risk factors: The Bogalusa Heart Study | Metabolism: Clinical and Experimental | 1996 | 449 |
| 37 | Laboratory animals exhibiting obesity and diabetes syndromes | Metabolism: Clinical and Experimental | 1977 | 448 |
| 38 | Cortisol secretion in relation to body fat distribution in obese premenopausal women | Metabolism: Clinical and Experimental | 1992 | 448 |
| 39 | Increased oxidative stress precedes the onset of high-fat diet–induced insulin resistance and obesity | Metabolism: Clinical and Experimental | 2008 | 443 |
| 40 | Correlation between blood fibrinolytic activity, plasminogen activator inhibitor level, plasma insulin level, and relative body weight in normal and obese subjects | Metabolism: Clinical and Experimental | 1986 | 442 |
| 41 | Plasma metabolomic profile in nonalcoholic fatty liver disease | Metabolism: Clinical and Experimental | 2011 | 433 |
| 42 | The comparative reductions of the plasma lipids and lipoproteins by dietary polyunsaturated fats: Salmon oil versus vegetable oils | Metabolism: Clinical and Experimental | 1983 | 431 |
| 43 | The health benefits of dietary fiber: Beyond the usual suspects of type 2 diabetes mellitus, cardiovascular disease and colon cancer | Metabolism: Clinical and Experimental | 2012 | 426 |
| 44 | Intramuscular lipid content is increased in obesity and decreased by weight loss | Metabolism: Clinical and Experimental | 2000 | 419 |
| 45 | Relationship of plasma leucine and α-ketoisocaproate during a L-[1-13C]leucine infusion in man: A method for measuring human intracellular leucine tracer enrichment | Metabolism: Clinical and Experimental | 1982 | 417 |
| 46 | Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause | Metabolism: Clinical and Experimental | 1991 | 417 |
| 47 | Obesity and cardiovascular disease: revisiting an old relationship | Metabolism: Clinical and Experimental | 2019 | 416 |
| 48 | Oxidative stress and glycemic regulation | Metabolism: Clinical and Experimental | 2000 | 411 |
| 49 | Homocysteinemia due to folate deficiency | Metabolism: Clinical and Experimental | 1987 | 404 |
| 50 | The effects of glucocorticoids on adipose tissue lipid metabolism | Metabolism: Clinical and Experimental | 2011 | 403 |
