| # | Title | Journal | Year | Citations |
|---|
| 1 | A new taxonomy for describing and defining adherence to medications | British Journal of Clinical Pharmacology | 2012 | 1,308 |
| 2 | The two‐period cross‐over clinical trial. | British Journal of Clinical Pharmacology | 1979 | 1,280 |
| 3 | Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications | British Journal of Clinical Pharmacology | 2003 | 1,212 |
| 4 | Omega‐3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology? | British Journal of Clinical Pharmacology | 2013 | 950 |
| 5 | Validation and validity of diagnoses in the General Practice Research Database: a systematic review | British Journal of Clinical Pharmacology | 2010 | 944 |
| 6 | Pulmonary drug delivery. Part I: Physiological factors affecting therapeutic effectiveness of aerosolized medications | British Journal of Clinical Pharmacology | 2003 | 881 |
| 7 | The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects | British Journal of Clinical Pharmacology | 2007 | 830 |
| 8 | Cytochrome P4502C9: an enzyme of major importance in human drug metabolism | British Journal of Clinical Pharmacology | 1998 | 752 |
| 9 | Grapefruit juice–drug interactions | British Journal of Clinical Pharmacology | 1998 | 667 |
| 10 | Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine | British Journal of Clinical Pharmacology | 1999 | 605 |
| 11 | Bioavailability of bioactive food compounds: a challenging journey to bioefficacy | British Journal of Clinical Pharmacology | 2013 | 582 |
| 12 | Clinical relevance of genetic polymorphisms in the human CYP2C subfamily | British Journal of Clinical Pharmacology | 2001 | 530 |
| 13 | Use of the UK General Practice Research Database for pharmacoepidemiology | British Journal of Clinical Pharmacology | 1998 | 513 |
| 14 | Clinically relevant drug interactions with antiepileptic drugs | British Journal of Clinical Pharmacology | 2006 | 502 |
| 15 | Which drugs cause preventable admissions to hospital? A systematic review | British Journal of Clinical Pharmacology | 2007 | 499 |
| 16 | The revision of the Declaration of Helsinki: past, present and future | British Journal of Clinical Pharmacology | 2004 | 495 |
| 17 | Pulse wave analysis | British Journal of Clinical Pharmacology | 2001 | 488 |
| 18 | Psychomotor function and psychoactive drugs. | British Journal of Clinical Pharmacology | 1980 | 476 |
| 19 | A systematic review of the emerging definition of ‘deprescribing’ with network analysis: implications for future research and clinical practice. | British Journal of Clinical Pharmacology | 2015 | 461 |
| 20 | Molecular genetics of CYP2D6: Clinical relevance with focus on psychotropic drugs | British Journal of Clinical Pharmacology | 2002 | 456 |
| 21 | The UK Prospective Diabetes Study (UKPDS): clinical and therapeutic implications for type 2 diabetes | British Journal of Clinical Pharmacology | 1999 | 436 |
| 22 | The pharmacokinetics and the pharmacodynamics of cannabinoids | British Journal of Clinical Pharmacology | 2018 | 422 |
| 23 | The effect of selective serotonin re‐uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes. | British Journal of Clinical Pharmacology | 1992 | 414 |
| 24 | Pharmacokinetic and pharmacodynamic properties of oral L‐citrulline and L‐arginine: impact on nitric oxide metabolism | British Journal of Clinical Pharmacology | 2008 | 403 |
| 25 | Pharmaceutical innovation by the seven UK‐owned pharmaceutical companies (1964‐1985). | British Journal of Clinical Pharmacology | 1988 | 399 |
| 26 | Incidence of adverse drug reactions in paediatric in/out-patients: a systematic review and meta-analysis of prospective studies | British Journal of Clinical Pharmacology | 2001 | 391 |
| 27 | Polypharmacy as commonly defined is an indicator of limited value in the assessment of drug-related problems | British Journal of Clinical Pharmacology | 2007 | 384 |
| 28 | Sensitivity and accuracy of the visual analogue scale: a psycho‐ physical classroom experiment. | British Journal of Clinical Pharmacology | 1978 | 377 |
| 29 | Medical management of paraquat ingestion | British Journal of Clinical Pharmacology | 2011 | 374 |
| 30 | Adverse drug reactions in elderly patients | British Journal of Clinical Pharmacology | 2003 | 367 |
| 31 | Adverse drug reactions in special populations – the elderly | British Journal of Clinical Pharmacology | 2015 | 366 |
| 32 | Effects of renal impairment on the pharmacokinetics, pharmacodynamics and safety of rivaroxaban, an oral, direct Factor Xa inhibitor | British Journal of Clinical Pharmacology | 2010 | 362 |
| 33 | Kinetics and metabolism of paracetamol and phenacetin. | British Journal of Clinical Pharmacology | 1980 | 358 |
| 34 | Metformin kinetics in healthy subjects and in patients with diabetes mellitus. | British Journal of Clinical Pharmacology | 1981 | 358 |
| 35 | Acute and clinically relevant drug-induced liver injury: a population based case-control study | British Journal of Clinical Pharmacology | 2004 | 356 |
| 36 | A comparison of the cardiovascular effects of levobupivacaine and rac-bupivacaine following intravenous administration to healthy volunteers | British Journal of Clinical Pharmacology | 1998 | 347 |
| 37 | Ketamine for chronic pain: risks and benefits | British Journal of Clinical Pharmacology | 2014 | 344 |
| 38 | Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects. | British Journal of Clinical Pharmacology | 1983 | 339 |
| 39 | The feasibility and effect of deprescribing in older adults on mortality and health: a systematic review and meta‐analysis | British Journal of Clinical Pharmacology | 2016 | 329 |
| 40 | Pulmonary drug delivery. Part II: The role of inhalant delivery devices and drug formulations in therapeutic effectiveness of aerosolized medications | British Journal of Clinical Pharmacology | 2003 | 326 |
| 41 | Potentially inappropriate prescribing and cost outcomes for older people: a national population study | British Journal of Clinical Pharmacology | 2010 | 326 |
| 42 | Polypharmacy and falls in the middle age and elderly population | British Journal of Clinical Pharmacology | 2006 | 322 |
| 43 | Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir | British Journal of Clinical Pharmacology | 1997 | 313 |
| 44 | Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases | British Journal of Clinical Pharmacology | 2015 | 312 |
| 45 | St John's wort (Hypericum perforatum ): drug interactions and clinical outcomes | British Journal of Clinical Pharmacology | 2002 | 311 |
| 46 | Cannabinoids for treatment of chronic non‐cancer pain; a systematic review of randomized trials | British Journal of Clinical Pharmacology | 2011 | 310 |
| 47 | Benefits and strengths of the disproportionality analysis for identification of adverse drug reactions in a pharmacovigilance database | British Journal of Clinical Pharmacology | 2011 | 309 |
| 48 | What is the best size descriptor to use for pharmacokinetic studies in the obese? | British Journal of Clinical Pharmacology | 2004 | 306 |
| 49 | Non-linear pharmacokinetics of MDMA (‘ecstasy’) in humans | British Journal of Clinical Pharmacology | 2000 | 304 |
| 50 | Co‐administration of rivaroxaban with drugs that share its elimination pathways: pharmacokinetic effects in healthy subjects | British Journal of Clinical Pharmacology | 2013 | 303 |
