| # | Title | Journal | Year | Citations |
|---|
| 1 | The macrophage theory of depression | Medical Hypotheses | 1991 | 812 |
| 2 | A “mitochondrial cascade hypothesis” for sporadic Alzheimer's disease | Medical Hypotheses | 2004 | 579 |
| 3 | COVIDiagnosis-Net: Deep Bayes-SqueezeNet based diagnosis of the coronavirus disease 2019 (COVID-19) from X-ray images | Medical Hypotheses | 2020 | 573 |
| 4 | A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol | Medical Hypotheses | 2006 | 491 |
| 5 | Acupuncture — from empiricism to science: Functional background to acupuncture effects in pain and disease Pain and disease | Medical Hypotheses | 1995 | 447 |
| 6 | Effects of yoga on the autonomic nervous system, gamma-aminobutyric-acid, and allostasis in epilepsy, depression, and post-traumatic stress disorder | Medical Hypotheses | 2012 | 415 |
| 7 | Pathophysiological mechanisms involved in genesis and spread of muscular tension in occupational muscle pain and in chronic musculoskeletal pain syndromes: A hypothesis | Medical Hypotheses | 1991 | 365 |
| 8 | Cytokine–serotonin interaction through IDO: a neurodegeneration hypothesis of depression | Medical Hypotheses | 2003 | 360 |
| 9 | Physiology of long pranayamic breathing: Neural respiratory elements may provide a mechanism that explains how slow deep breathing shifts the autonomic nervous system | Medical Hypotheses | 2006 | 336 |
| 10 | Refined food addiction: A classic substance use disorder | Medical Hypotheses | 2009 | 308 |
| 11 | Lighting for the human circadian clock: recent research indicates that lighting has become a public health issue | Medical Hypotheses | 2004 | 302 |
| 12 | Autism: a novel form of mercury poisoning | Medical Hypotheses | 2001 | 293 |
| 13 | Modic changes, possible causes and relation to low back pain | Medical Hypotheses | 2008 | 292 |
| 14 | Intracellular hyperthermia a biophysical approach to cancer treatment via intracellular temperature and biophysical alterations | Medical Hypotheses | 1979 | 278 |
| 15 | The neural basis of the complex mental task of meditation: neurotransmitter and neurochemical considerations | Medical Hypotheses | 2003 | 271 |
| 16 | SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression | Medical Hypotheses | 2020 | 268 |
| 17 | Bile acid-induced liver toxicity: Relation to the hydrophobic-hydrophilic balance of bile acids | Medical Hypotheses | 1986 | 261 |
| 18 | Mathematical formulae for the prediction of the residual beta cell function during the first two years of disease in children and adolescents with insulin-dependent diabetes mellitus | Medical Hypotheses | 1995 | 253 |
| 19 | PTH excess may promote weight gain by impeding catecholamine-induced lipolysis-implications for the impact of calcium, vitamin D, and alcohol on body weight | Medical Hypotheses | 2003 | 245 |
| 20 | Autism and vitamin D | Medical Hypotheses | 2008 | 241 |
| 21 | A new three-dimensional model for emotions and monoamine neurotransmitters | Medical Hypotheses | 2012 | 239 |
| 22 | Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders | Medical Hypotheses | 1992 | 238 |
| 23 | Major depressive disorder: probiotics may be an adjuvant therapy | Medical Hypotheses | 2005 | 225 |
| 24 | Deep brain stimulation of the lateral habenula in treatment resistant major depression | Medical Hypotheses | 2007 | 224 |
| 25 | Pathophysiological model for chronic low back pain integrating connective tissue and nervous system mechanisms | Medical Hypotheses | 2007 | 222 |
| 26 | A threshold concept for cancer therapy | Medical Hypotheses | 2000 | 218 |
| 27 | Rapid recovery from major depression using magnesium treatment | Medical Hypotheses | 2006 | 213 |
| 28 | Loop mediated isothermal amplification (LAMP) assays as a rapid diagnostic for COVID-19 | Medical Hypotheses | 2020 | 213 |
| 29 | The hypogonadal–obesity cycle: role of aromatase in modulating the testosterone–estradiol shunt – a major factor in the genesis of morbid obesity | Medical Hypotheses | 1999 | 211 |
| 30 | The inflammatory consequences of psychologic stress: Relationship to insulin resistance, obesity, atherosclerosis and diabetes mellitus, type II | Medical Hypotheses | 2006 | 210 |
| 31 | Detection of tumors on brain MRI images using the hybrid convolutional neural network architecture | Medical Hypotheses | 2020 | 209 |
| 32 | Interleukin-6 as a central mediator of cardiovascular risk associated with chronic inflammation, smoking, diabetes, and visceral obesity: down-regulation with essential fatty acids, ethanol and pentoxifylline | Medical Hypotheses | 1999 | 207 |
| 33 | Airborne route and bad use of ventilation systems as non-negligible factors in SARS-CoV-2 transmission | Medical Hypotheses | 2020 | 205 |
| 34 | Tracing the origins of “fetal origins” of adult diseases: Programming by oxidative stress? | Medical Hypotheses | 2006 | 204 |
| 35 | Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology | Medical Hypotheses | 2009 | 202 |
| 36 | Sublethal mitochondrial stress with an attendant stoichiometric augmentation of reactive oxygen species may precipitate many of the beneficial alterations in cellular physiology produced by caloric restriction, intermittent fasting, exercise and dietary phytonutrients: “Mitohormesis” for health and vitality | Medical Hypotheses | 2006 | 201 |
| 37 | Music, memory, and Alzheimer’s disease: is music recognition spared in dementia, and how can it be assessed? | Medical Hypotheses | 2005 | 200 |
| 38 | An exploratory approach to the serotonin syndrome: an update of clinical phenomenology and revised diagnostic criteria | Medical Hypotheses | 2000 | 198 |
| 39 | The anabolic benefits of venous blood flow restriction training may be induced by muscle cell swelling | Medical Hypotheses | 2012 | 195 |
| 40 | Dysbiosis of Gut Microbiota (DOGMA) – A novel theory for the development of Polycystic Ovarian Syndrome | Medical Hypotheses | 2012 | 195 |
| 41 | D2 dopamine receptor gene and cigarette smoking: A reward gene? | Medical Hypotheses | 1994 | 194 |
| 42 | C-reactive protein is not only an inflammatory marker but also a direct cause of cardiovascular diseases | Medical Hypotheses | 2004 | 193 |
| 43 | Burnout syndrome in Romanian medical residents in time of the COVID-19 pandemic | Medical Hypotheses | 2020 | 191 |
| 44 | The macrophage-T-lymphocyte theory of schizophrenia: Additional evidence | Medical Hypotheses | 1995 | 190 |
| 45 | Pretty painful: Why does tooth bleaching hurt? | Medical Hypotheses | 2010 | 188 |
| 46 | Sleep and muscle recovery: Endocrinological and molecular basis for a new and promising hypothesis | Medical Hypotheses | 2011 | 187 |
| 47 | Cancer chemoprevention: Selenium as a prooxidant, not an antioxidant | Medical Hypotheses | 2006 | 185 |
| 48 | Multiple sclerosis: Decreased relapse rate through dietary supplementation with calcium, magnesium and vitamin D | Medical Hypotheses | 1986 | 184 |
| 49 | Sleep disturbance as a universal risk factor for relapse in addictions to psychoactive substances | Medical Hypotheses | 2010 | 182 |
| 50 | The free radical flux theory of sleep | Medical Hypotheses | 1994 | 181 |
