| # | Title | Journal | Year | Citations |
|---|
| 1 | The detection of disease clustering and a generalized regression approach | Cancer Research | 1967 | 8,008 |
| 2 | Normalization of Real-Time Quantitative Reverse Transcription-PCR Data: A Model-Based Variance Estimation Approach to Identify Genes Suited for Normalization, Applied to Bladder and Colon Cancer Data Sets | Cancer Research | 2004 | 5,993 |
| 3 | Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States | Cancer Research | 2014 | 5,433 |
| 4 | A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs | Cancer Research | 1986 | 5,187 |
| 5 | Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method | Cancer Research | 2010 | 4,304 |
| 6 | TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells | Cancer Research | 2017 | 4,049 |
| 7 | ras oncogenes in human cancer: a review | Cancer Research | 1989 | 3,985 |
| 8 | MicroRNA Gene Expression Deregulation in Human Breast Cancer | Cancer Research | 2005 | 3,719 |
| 9 | BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis | Cancer Research | 2004 | 3,718 |
| 10 | Identification of a cancer stem cell in human brain tumors | Cancer Research | 2003 | 3,675 |
| 11 | Computational Radiomics System to Decode the Radiographic Phenotype | Cancer Research | 2017 | 3,458 |
| 12 | Report of the Committee on Hodgkin's Disease Staging Classification | Cancer Research | 1971 | 3,207 |
| 13 | Identification of Pancreatic Cancer Stem Cells | Cancer Research | 2007 | 3,017 |
| 14 | A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer | Cancer Research | 1998 | 2,999 |
| 15 | Participation of p53 protein in the cellular response to DNA damage | Cancer Research | 1991 | 2,869 |
| 16 | Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing | Cancer Research | 1987 | 2,867 |
| 17 | Prospective Identification of Tumorigenic Prostate Cancer Stem Cells | Cancer Research | 2005 | 2,564 |
| 18 | Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review | Cancer Research | 1989 | 2,558 |
| 19 | Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis | Cancer Research | 1994 | 2,504 |
| 20 | mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt | Cancer Research | 2006 | 2,329 |
| 21 | Isolation and Characterization of Tumorigenic, Stem-like Neural Precursors from Human Glioblastoma | Cancer Research | 2004 | 2,318 |
| 22 | MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells | Cancer Research | 2005 | 2,315 |
| 23 | Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival | Cancer Research | 2004 | 2,287 |
| 24 | Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay | Cancer Research | 1988 | 2,244 |
| 25 | Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention | Cancer Research | 1992 | 2,154 |
| 26 | KRAS Mutation Status Is Predictive of Response to Cetuximab Therapy in Colorectal Cancer | Cancer Research | 2006 | 2,116 |
| 27 | Long Noncoding RNA and Cancer: A New Paradigm | Cancer Research | 2017 | 2,080 |
| 28 | Distinct Role of Macrophages in Different Tumor Microenvironments | Cancer Research | 2006 | 1,922 |
| 29 | Production of large amounts of hydrogen peroxide by human tumor cells | Cancer Research | 1991 | 1,841 |
| 30 | Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases | Cancer Research | 1999 | 1,791 |
| 31 | The Tumor Microenvironment Innately Modulates Cancer Progression | Cancer Research | 2019 | 1,781 |
| 32 | Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines | Cancer Research | 1988 | 1,768 |
| 33 | The histogenesis and biologic behavior of primary human malignant melanomas of the skin | Cancer Research | 1969 | 1,679 |
| 34 | ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor | Cancer Research | 2008 | 1,666 |
| 35 | Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors | Cancer Research | 2012 | 1,657 |
| 36 | Isolation and In vitro Propagation of Tumorigenic Breast Cancer Cells with Stem/Progenitor Cell Properties | Cancer Research | 2005 | 1,650 |
| 37 | WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis | Cancer Research | 1994 | 1,638 |
| 38 | A Comprehensive Survey of Ras Mutations in Cancer | Cancer Research | 2012 | 1,602 |
| 39 | DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells | Cancer Research | 2001 | 1,528 |
| 40 | A Polycistronic MicroRNA Cluster, miR-17-92, Is Overexpressed in Human Lung Cancers and Enhances Cell Proliferation | Cancer Research | 2005 | 1,479 |
| 41 | Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis | Cancer Research | 1993 | 1,427 |
| 42 | A gene hypermethylation profile of human cancer | Cancer Research | 2001 | 1,426 |
| 43 | Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody–Cytotoxic Drug Conjugate | Cancer Research | 2008 | 1,422 |
| 44 | The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells | Cancer Research | 2013 | 1,413 |
| 45 | A rapid in vitro assay for quantitating the invasive potential of tumor cells | Cancer Research | 1987 | 1,405 |
| 46 | A History of Cancer Chemotherapy | Cancer Research | 2008 | 1,362 |
| 47 | MicroRNA Signatures in Human Ovarian Cancer | Cancer Research | 2007 | 1,356 |
| 48 | Sorafenib Blocks the RAF/MEK/ERK Pathway, Inhibits Tumor Angiogenesis, and Induces Tumor Cell Apoptosis in Hepatocellular Carcinoma Model PLC/PRF/5 | Cancer Research | 2006 | 1,315 |
| 49 | Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix | Cancer Research | 1996 | 1,313 |
| 50 | Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape | Cancer Research | 2012 | 1,311 |
