| # | Title | Journal | Year | Citations |
|---|
| 1 | Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group | Critical Care | 2004 | 5,531 |
| 2 | Hepatic platelet and leukocyte adherence during endotoxemia | Critical Care | 2006 | 5,093 |
| 3 | Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1) | Critical Care | 2013 | 1,724 |
| 4 | RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis | Critical Care | 2006 | 1,246 |
| 5 | Sepsis biomarkers: a review | Critical Care | 2010 | 1,018 |
| 6 | The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition | Critical Care | 2016 | 1,014 |
| 7 | Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury | Critical Care | 2013 | 969 |
| 8 | The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition | Critical Care | 2019 | 878 |
| 9 | A positive fluid balance is associated with a worse outcome in patients with acute renal failure | Critical Care | 2008 | 793 |
| 10 | Management of bleeding and coagulopathy following major trauma: an updated European guideline | Critical Care | 2013 | 780 |
| 11 | Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19 | Critical Care | 2020 | 768 |
| 12 | Bench-to-bedside review: Rhabdomyolysis -- an overview for clinicians | Critical Care | 2004 | 736 |
| 13 | Management of bleeding following major trauma: an updated European guideline | Critical Care | 2010 | 694 |
| 14 | How to evaluate the microcirculation: report of a round table conference | Critical Care | 2007 | 685 |
| 15 | Statistics review 13: receiver operating characteristic curves | Critical Care | 2004 | 661 |
| 16 | Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445] | Critical Care | 2005 | 632 |
| 17 | Clinical review: complications and risk factors of peripheral arterial catheters used for haemodynamic monitoring in anaesthesia and intensive care medicine | Critical Care | 2002 | 631 |
| 18 | The microcirculation is the motor of sepsis | Critical Care | 2005 | 617 |
| 19 | Toxicity of polymyxins: a systematic review of the evidence from old and recent studies | Critical Care | 2006 | 604 |
| 20 | Burn wound healing and treatment: review and advancements | Critical Care | 2015 | 603 |
| 21 | Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM®)-guided administration of fibrinogen concentrate and prothrombin complex concentrate | Critical Care | 2010 | 582 |
| 22 | Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis | Critical Care | 2007 | 580 |
| 23 | Identifying critically ill patients who benefit the most from nutrition therapy: the development and initial validation of a novel risk assessment tool | Critical Care | 2011 | 564 |
| 24 | Therapeutic and toxic blood concentrations of nearly 1,000 drugs and other xenobiotics | Critical Care | 2012 | 563 |
| 25 | Real-time ultrasound-guided catheterisation of the internal jugular vein: a prospective comparison with the landmark technique in critical care patients | Critical Care | 2006 | 542 |
| 26 | 0.9% saline versus Plasma-Lyte as initial fluid in children with diabetic ketoacidosis (SPinK trial): a double-blind randomized controlled trial | Critical Care | 2020 | 528 |
| 27 | Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study | Critical Care | 2005 | 522 |
| 28 | Identification and characterisation of the high-risk surgical population in the United Kingdom | Critical Care | 2006 | 517 |
| 29 | Early acute kidney injury and sepsis: a multicentre evaluation | Critical Care | 2008 | 517 |
| 30 | Acute respiratory failure in COVID-19: is it “typical” ARDS? | Critical Care | 2020 | 517 |
| 31 | A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome | Critical Care | 2017 | 515 |
| 32 | COVID-19 pneumonia: ARDS or not? | Critical Care | 2020 | 504 |
| 33 | Clinical review: hemorrhagic shock | Critical Care | 2004 | 479 |
| 34 | Statistics review 4: sample size calculations | Critical Care | 2002 | 471 |
| 35 | Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients | Critical Care | 2005 | 469 |
| 36 | Statistics review 14: Logistic regression | Critical Care | 2005 | 461 |
| 37 | Clinical review: Scoring systems in the critically ill | Critical Care | 2010 | 458 |
| 38 | The SOFA score—development, utility and challenges of accurate assessment in clinical trials | Critical Care | 2019 | 456 |
| 39 | Clinical review: intensive care unit acquired weakness | Critical Care | 2015 | 452 |
| 40 | The inflammatory response to extracorporeal membrane oxygenation (ECMO): a review of the pathophysiology | Critical Care | 2016 | 452 |
| 41 | Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit | Critical Care | 2010 | 449 |
| 42 | Delirium in the intensive care unit | Critical Care | 2008 | 441 |
| 43 | Severe burn injury in europe: a systematic review of the incidence, etiology, morbidity, and mortality | Critical Care | 2010 | 426 |
| 44 | Host susceptibility to severe COVID-19 and establishment of a host risk score: findings of 487 cases outside Wuhan | Critical Care | 2020 | 425 |
| 45 | Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study | Critical Care | 2007 | 416 |
| 46 | Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trial | Critical Care | 2010 | 416 |
| 47 | The impact of compliance with 6-hour and 24-hour sepsis bundles on hospital mortality in patients with severe sepsis: a prospective observational study | Critical Care | 2005 | 412 |
| 48 | Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis | Critical Care | 2006 | 412 |
| 49 | Percutaneous dilatational tracheostomy versus surgical tracheostomy in critically ill patients: a systematic review and meta-analysis | Critical Care | 2006 | 411 |
| 50 | Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care | Critical Care | 2000 | 400 |
