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Top Articles

#TitleJournalYearCitations
1Antioxidant activity applying an improved ABTS radical cation decolorization assayFree Radical Biology and Medicine199919,369
2Structure-antioxidant activity relationships of flavonoids and phenolic acidsFree Radical Biology and Medicine19967,250
3Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydesFree Radical Biology and Medicine19916,005
4Oxidative stress, inflammation, and cancer: How are they linked?Free Radical Biology and Medicine20104,326
5Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione coupleFree Radical Biology and Medicine20013,992
6Oxidative mechanisms in the toxicity of metal ionsFree Radical Biology and Medicine19953,654
7Reactive oxygen species, cellular redox systems, and apoptosisFree Radical Biology and Medicine20102,901
8Mitochondrial free radical generation, oxidative stress, and aging11This article is dedicated to the memory of our dear friend, colleague, and mentor Lars Ernster (1920–1998), in gratitude for all he gave to us.Free Radical Biology and Medicine20002,626
9Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injuryFree Radical Biology and Medicine19902,311
10Reactive oxygen species, antioxidants, and the mammalian thioredoxin system1 1This review is based on the licentiate thesis “Thioredoxin reductase—interactions with the redox active compounds 1-chloro-2,4-dinitrobenzene and lipoic acid” by Jonas Nordberg, 2001, Karolinska Institute, Stockholm, ISBN 91-631-1064-4.Free Radical Biology and Medicine20012,283
11Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader11Mention of a trade name, proprietary product, or specific equipment does not constitute a guarantee by the United States Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.Free Radical Biology and Medicine19992,141
12Oxidative Stress Hypothesis in Alzheimer's DiseaseFree Radical Biology and Medicine19972,095
13The role of lipid peroxidation and antioxidants in oxidative modification of LDLFree Radical Biology and Medicine19922,071
14Antioxidant and Prooxidant Behavior of Flavonoids: Structure-Activity RelationshipsFree Radical Biology and Medicine19971,968
15Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expressionFree Radical Biology and Medicine20021,802
16Flavonoids: antioxidants or signalling molecules?Free Radical Biology and Medicine20041,773
17Alpha-lipoic acid as a biological antioxidantFree Radical Biology and Medicine19951,747
18The thioredoxin antioxidant systemFree Radical Biology and Medicine20141,644
19Spin Trapping: ESR parameters of spin adducts 1474 1528VFree Radical Biology and Medicine19871,624
20The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acidFree Radical Biology and Medicine19891,605
21Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitationsFree Radical Biology and Medicine20121,487
22Glutathione and its role in cellular functionsFree Radical Biology and Medicine19991,470
23Nrf2:INrf2 (Keap1) signaling in oxidative stressFree Radical Biology and Medicine20091,434
24Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxideFree Radical Biology and Medicine19981,403
25Oxygen-radical absorbance capacity assay for antioxidantsFree Radical Biology and Medicine19931,286
26Oxidants as Stimulators of Signal TransductionFree Radical Biology and Medicine19971,260
27The role of oxidized lipoproteins in atherogenesisFree Radical Biology and Medicine19961,249
28Peroxiredoxins: A historical overview and speculative preview of novel mechanisms and emerging concepts in cell signalingFree Radical Biology and Medicine20051,248
29Triggering and modulation of apoptosis by oxidative stressFree Radical Biology and Medicine20001,192
30Vitamin E, antioxidant and nothing moreFree Radical Biology and Medicine20071,135
31Oxidative stress and gene regulationFree Radical Biology and Medicine20001,131
32Nrf2 signaling in coordinated activation of antioxidant gene expressionFree Radical Biology and Medicine20041,124
33Superoxide and hydrogen peroxide in relation to mammalian cell proliferationFree Radical Biology and Medicine19951,077
34Thiol chemistry and specificity in redox signalingFree Radical Biology and Medicine20081,074
35Lipid peroxidation and ferroptosis: The role of GSH and GPx4Free Radical Biology and Medicine20201,065
36Structural aspects of antioxidant activity of flavonoidsFree Radical Biology and Medicine19961,061
37Biologic and pharmacologic regulation of mammalian glutathione synthesisFree Radical Biology and Medicine19991,047
38Metal ion-catalyzed oxidation of proteins: Biochemical mechanism and biological consequencesFree Radical Biology and Medicine19901,019
39Importance of SE-glutathione peroxidase, catalase, and CU/ZN-SOD for cell survival against oxidative stressFree Radical Biology and Medicine19941,011
40Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissuesFree Radical Biology and Medicine19961,011
41Role of GPX4 in ferroptosis and its pharmacological implicationFree Radical Biology and Medicine2019995
42Antioxidant potential of ferulic acidFree Radical Biology and Medicine1992964
43Mitochondria and reactive oxygen speciesFree Radical Biology and Medicine2009945
44Tissue-specific functions of individual glutathione peroxidasesFree Radical Biology and Medicine1999940
45Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteinsFree Radical Biology and Medicine2004931
46Free radicals, antioxidant enzymes, and carcinogenesisFree Radical Biology and Medicine1990927
47Trends in oxidative aging theoriesFree Radical Biology and Medicine2007915
48Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress 1,2 1Guest Editors: Mark A. Smith and George Perry 2This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.Free Radical Biology and Medicine2002914
49Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer propertiesFree Radical Biology and Medicine2004914
50Reactions of oxyl radicals with DNAFree Radical Biology and Medicine1995908