| # | Title | Journal | Year | Citations |
|---|
| 1 | The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus | New England Journal of Medicine | 1993 | 22,781 |
| 2 | Clinical Characteristics of Coronavirus Disease 2019 in China | New England Journal of Medicine | 2020 | 22,372 |
| 3 | A Novel Coronavirus from Patients with Pneumonia in China, 2019 | New England Journal of Medicine | 2020 | 21,542 |
| 4 | Atherosclerosis — An Inflammatory Disease | New England Journal of Medicine | 1999 | 19,732 |
| 5 | Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma | New England Journal of Medicine | 2005 | 17,395 |
| 6 | Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin | New England Journal of Medicine | 2002 | 16,031 |
| 7 | Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome | New England Journal of Medicine | 2000 | 14,454 |
| 8 | Intensive Insulin Therapy in Critically Ill Patients | New England Journal of Medicine | 2001 | 14,320 |
| 9 | Improved Survival with Ipilimumab in Patients with Metastatic Melanoma | New England Journal of Medicine | 2010 | 13,065 |
| 10 | Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock | New England Journal of Medicine | 2001 | 12,968 |
| 11 | Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia | New England Journal of Medicine | 2020 | 12,326 |
| 12 | Vitamin D Deficiency | New England Journal of Medicine | 2007 | 12,281 |
| 13 | Sorafenib in Advanced Hepatocellular Carcinoma | New England Journal of Medicine | 2008 | 12,004 |
| 14 | Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine | New England Journal of Medicine | 2020 | 11,472 |
| 15 | Tissue Plasminogen Activator for Acute Ischemic Stroke | New England Journal of Medicine | 1995 | 11,321 |
| 16 | Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer | New England Journal of Medicine | 2012 | 10,727 |
| 17 | Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib | New England Journal of Medicine | 2004 | 10,632 |
| 18 | Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2 | New England Journal of Medicine | 2001 | 10,216 |
| 19 | Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer | New England Journal of Medicine | 2004 | 9,850 |
| 20 | Chronic Kidney Disease and the Risks of Death, Cardiovascular Events, and Hospitalization | New England Journal of Medicine | 2004 | 9,843 |
| 21 | Dabigatran versus Warfarin in Patients with Atrial Fibrillation | New England Journal of Medicine | 2009 | 9,839 |
| 22 | The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults | New England Journal of Medicine | 1993 | 9,133 |
| 23 | Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance | New England Journal of Medicine | 2001 | 9,083 |
| 24 | Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection | New England Journal of Medicine | 1998 | 8,991 |
| 25 | Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes | New England Journal of Medicine | 2015 | 8,841 |
| 26 | Tumor Angiogenesis: Therapeutic Implications | New England Journal of Medicine | 1971 | 8,607 |
| 27 | Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis | New England Journal of Medicine | 2001 | 8,411 |
| 28 | Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening | New England Journal of Medicine | 2011 | 8,392 |
| 29 | Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients | New England Journal of Medicine | 2000 | 8,226 |
| 30 | Beneficial Effect of Carotid Endarterectomy in Symptomatic Patients with High-Grade Carotid Stenosis | New England Journal of Medicine | 1991 | 8,207 |
| 31 | The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure | New England Journal of Medicine | 1999 | 8,093 |
| 32 | Dexamethasone in Hospitalized Patients with Covid-19 | New England Journal of Medicine | 2021 | 8,063 |
| 33 | Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation | New England Journal of Medicine | 2011 | 8,006 |
| 34 | Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2015 | 7,973 |
| 35 | Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine | New England Journal of Medicine | 2021 | 7,910 |
| 36 | Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2016 | 7,847 |
| 37 | PD-1 Blockade in Tumors with Mismatch-Repair Deficiency | New England Journal of Medicine | 2015 | 7,696 |
| 38 | Gefitinib or Carboplatin–Paclitaxel in Pulmonary Adenocarcinoma | New England Journal of Medicine | 2009 | 7,606 |
| 39 | Apixaban versus Warfarin in Patients with Atrial Fibrillation | New England Journal of Medicine | 2011 | 7,537 |
| 40 | Computed Tomography — An Increasing Source of Radiation Exposure | New England Journal of Medicine | 2007 | 7,498 |
| 41 | Inflammation, Atherosclerosis, and Coronary Artery Disease | New England Journal of Medicine | 2005 | 7,433 |
| 42 | Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1 | New England Journal of Medicine | 2020 | 7,369 |
| 43 | Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia | New England Journal of Medicine | 1995 | 7,264 |
| 44 | Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2015 | 7,261 |
| 45 | Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia | New England Journal of Medicine | 2002 | 7,156 |
| 46 | Spontaneous Initiation of Atrial Fibrillation by Ectopic Beats Originating in the Pulmonary Veins | New England Journal of Medicine | 1998 | 7,117 |
| 47 | Effects of Intensive Glucose Lowering in Type 2 Diabetes | New England Journal of Medicine | 2008 | 7,084 |
| 48 | The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels | New England Journal of Medicine | 1996 | 7,059 |
| 49 | Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation | New England Journal of Medicine | 2011 | 6,976 |
| 50 | Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest | New England Journal of Medicine | 2002 | 6,963 |
